Zobrazeno 1 - 10 of 276 pro vyhledávání: '"Carol Bentley"'
1
Akademický článek
Comprehensive mutagenesis identifies the peptide repertoire of a p53 T-cell receptor mimic antibody that displays no toxicity in mice transgenic for human HLA-A*0201.
Autor: Iva Trenevska, Amanda P Anderson, Carol Bentley, Tasneem Hassanali, Sarah Wiblin, Shaun Maguire, Francesco Pezzella, Alison H Banham, Demin Li
Publikováno v: PLoS ONE, Vol 16, Iss 4, p e0249967 (2021)
T-cell receptor mimic (TCRm) antibodies have expanded the repertoire of antigens targetable by monoclonal antibodies, to include peptides derived from intracellular proteins that are presented by major histocompatibility complex class I (MHC-I) molec
Externí odkaz: https://doaj.org/article/9ac3c2ac2ee84090b0a591c24d8b6a6d
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6
Akademický článek
Engineering chimeric human and mouse major histocompatibility complex (MHC) class I tetramers for the production of T-cell receptor (TCR) mimic antibodies.
Autor: Demin Li, Carol Bentley, Jenna Yates, Maryam Salimi, Jenny Greig, Sarah Wiblin, Tasneem Hassanali, Alison H Banham
Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0176642 (2017)
Therapeutic monoclonal antibodies targeting cell surface or secreted antigens are among the most effective classes of novel immunotherapies. However, the majority of human proteins and established cancer biomarkers are intracellular. Peptides derived
Externí odkaz: https://doaj.org/article/31aed34546f24c8981f2b91c934d61df
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7
Akademický článek
Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor.
Autor: Andrew J Massey, Jenifer Borgognoni, Carol Bentley, Nicolas Foloppe, Andrea Fiumana, Lee Walmsley
Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13123 (2010)
Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe
Externí odkaz: https://doaj.org/article/903dfe8154ea49fc90bc02d89bad8167
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8
Abstract C128: Development of therapeutic anti-Jagged1 monoclonal antibodies
Autor: Ji-Liang Li, Demin Li, Stephen M. Stribbling, Penny A. Handford, Carol Bentley, Adrian L. Harris, Massimo Masiero, Sarah K. Watts, Susan M. Lea, Jenny Greig, Tasneem Hassanali, Pat Whiteman, Alison H. Banham, Jenna Yates
Publikováno v: Molecular Cancer Therapeutics. 14:C128-C128
Background: The Notch pathway is an evolutionarily conserved cell-signaling system that plays an important role in both physiologic and pathologic conditions such as embryonic development and cancer. In the latter, Notch signaling has been reported t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aef8a2ec8c46bba5b9d1cccbb0f04bd2
https://doi.org/10.1158/1535-7163.targ-15-c128
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9
Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor
Autor: Andrea Fiumana, Andrew Massey, Lee Walmsley, Jenifer Borgognoni, Nicolas Foloppe, Carol Bentley
Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13123 (2010)
PLoS ONE
Background Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4600811eab764c8ca5897fc697d7665
http://europepmc.org/articles/PMC2956624?pdf=render
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10
Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blocked
Autor: Sarah Denny, Andrew Cansfield, Philip Stephen Jackson, Jonathan D. Moore, Douglas S. Williamson, Peter Kierstan, Lan-Zhen Wang, Simon F. Scrace, Joanne Wayne, Andrea M. Lockie, Nicola J. Curtin, Carol Bentley, David R. Newell, Jenifer Borgognoni
Publikováno v: Cell cycle (Georgetown, Tex.). 7(24)
Transient treatment with small molecule CDK inhibitors is toxic to cancer cells and leads to depletion of anti-apoptotic proteins and Chk1, coupled with DNA damage and induction of apoptosis. Here we have examined, which of these phenomena are necess
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8f0d6ba4c8ba95f6dc5729a377d973
https://pubmed.ncbi.nlm.nih.gov/19066455
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