Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Carol Basbaum"'
Autor:
Hassan Lemjabbar-Alaoui, Sukhvinder S Sidhu, Aklilu Mengistab, Marianne Gallup, Carol Basbaum
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17489 (2011)
Tobacco smoke predisposes humans and animals to develop lung tumors, but the molecular events responsible for this are poorly understood. We recently showed that signaling mechanisms triggered by smoke in lung cells could lead to the activation of a
Externí odkaz:
https://doaj.org/article/767bad90541f4f598c12f571092c33db
Autor:
Hassan Lemjabbar-Alaoui, Vijay Dasari, Sukhvinder S Sidhu, Aklilu Mengistab, Walter Finkbeiner, Marianne Gallup, Carol Basbaum
Publikováno v:
PLoS ONE, Vol 1, p e93 (2006)
Lung cancer is the leading cause of cancer death in the world, and greater than 90% of lung cancers are cigarette smoke-related. Current treatment options are inadequate, because the molecular basis of cigarette-induced lung cancer is poorly understo
Externí odkaz:
https://doaj.org/article/b10941c3ac87476caa926922151a88a5
Publikováno v:
Chest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc8a7a3bf5dffa3af4695eeb450e08d
http://europepmc.org/articles/PMC7094328
http://europepmc.org/articles/PMC7094328
Autor:
Nancy A. McNamara, Suzanne M. J. Fleiszig, Carol Basbaum, Sukhvinder Sidhu, Sheena C. Kerr, David J. Evans, Inna Maltseva
Publikováno v:
Experimental Eye Research. 85:142-153
Bacterial keratitis is a sight-threatening complication of contact lens wear, and Pseudomonas aeruginosa is a commonly isolated pathogen. The mechanisms by which lenses predispose the cornea to P. aeruginosa infection are unknown. Corneal epithelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8ed1f26b727cad8b34fcafc7ae3607
https://doi.org/10.1016/j.exer.2007.04.001
https://doi.org/10.1016/j.exer.2007.04.001
Autor:
Anatol Sucher, Nancy A. McNamara, Inna Maltseva, Carol Basbaum, David D. McKemy, Marianne Gallup
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 34:653-660
Bacterial flagellin can interact with both Toll-like receptor 5 (TLR5) and the cell surface glycolipid, asialoGM1, to activate an innate immune response. The induction of mucin by flagellin in human lung epithelial cells (NCIH292) is dependent on asi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bb2ab35ed1248526d408c796a47913
https://doi.org/10.1165/rcmb.2005-0441oc
https://doi.org/10.1165/rcmb.2005-0441oc
Autor:
Jan Lehmann, Hirokazu Tamamura, Sukhvinder Sidhu, Carol Basbaum, Nobutaka Fujii, Margitta Retz
Publikováno v:
European Urology. 48:1025-1030
Objective The CXCR4/CXCL12 axis appears crucial in the metastasis of bladder cancer. Our aim was to evaluate the potency of the CXCR4 antagonist, 4F-benzoyl-TE14011 (4F-bTE), as an anti-metastatic drug in this disease. In this study, we assessed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49766bac896cedcad6d84be91bb2006
https://doi.org/10.1016/j.eururo.2005.07.016
https://doi.org/10.1016/j.eururo.2005.07.016
Autor:
Carol Basbaum, Donald M. McDonald, Arin B. Aurora, Sukhvinder Sidhu, Peter Baluk, Gregory Dolganov, Dongji Zhang, Nigel Killeen
Publikováno v:
The Journal of Immunology. 175:6319-6326
Chronic inflammation in the airways is associated with dramatic architectural changes in the walls of the airways and in the vasculature they contain. In this study, we show that the adaptive immune system is essential for airway remodeling that occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f943c4dba85171484279128d0d85e59b
https://doi.org/10.4049/jimmunol.175.10.6319
https://doi.org/10.4049/jimmunol.175.10.6319
Publikováno v:
Biochemical and Biophysical Research Communications
Summary Airway mucus hypersecretion occurs in response to infection and irritation and poses an important and poorly understood clinical problem. In order to gain insight into its pathogenesis, we have focused on an mRNA encoding the major mucus glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f884d50ee6604cb4c1a2f974fc3d4474
http://europepmc.org/articles/PMC7111198
http://europepmc.org/articles/PMC7111198
Autor:
Yuichi Majima, Shinya Suzuki, Hajime Ishinaga, Kazuhiko Takeuchi, Chikako Kishioka, Carol Basbaum
Publikováno v:
Pharmacology. 73:89-96
Pranlukast is a selective cysteinyl leukotriene1 (cysLT1) receptor antagonist, and is now widely used in the treatment of asthma. The anti-asthmatic effect of pranlukast may be rendered not only by antileukotriene activity, but also by other pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd47215ed9ed0b17a5e20c2dee43b04a
https://doi.org/10.1159/000081294
https://doi.org/10.1159/000081294
Autor:
Jae Hyang Lim, Ran Chen, Hirofumi Jono, Jian Dong Li, Young S. Kim, Timothy F. Murphy, Xin Xing Gu, Carol Basbaum
Publikováno v:
Biochemical and Biophysical Research Communications. 324:1087-1094
Mucin overproduction is a hallmark of nontypeable Haemophilus influenzae (NTHi) infections. The molecular mechanisms underlying up-regulation of mucin in NTHi infections especially during the initial phase remain unknown. Here we show that P6, a 16-k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898c82fa3869af8368ed9a37fb29383a
https://doi.org/10.1016/j.bbrc.2004.09.157
https://doi.org/10.1016/j.bbrc.2004.09.157