Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Carol B. Kobrin"'
Autor:
Sattva S. Neelapu, Kieron Dunleavy, Maryalice Stetler-Stevenson, Therese White, Frances T. Hakim, Robin Pennington, Elaine S. Jaffe, John E. Janik, Seth M. Steinberg, Ronald E. Gress, Wyndham H. Wilson, Craig W. Reynolds, Linda K. Harvey, Carol B. Kobrin, Larry W. Kwak
Publikováno v:
Nature Medicine. 11:986-991
The role of B cells in T-cell priming is unclear, and the effects of B-cell depletion on immune responses to cancer vaccines are unknown. Although results from some mouse models suggest that B cells may inhibit induction of T cell–dependent immunit
Publikováno v:
Journal of Clinical Investigation. 113:1498-1510
The clonotypic surface Ig receptor expressed by malignant B cells, idiotype, is a tumor-specific antigen and an attractive target for active immunotherapy. While Ab's specific for tumor idiotype have been well described in patients with B cell malign
Autor:
Thelma M. Watson, Elaine S. Jaffe, Barry L. Gause, Craig W. Reynolds, Robin Pennington, Carol B. Kobrin, Lars Sternas, P L Duffey, Dan L. Longo, Floyd A. Benko, Christopher D. Gocke, Maurizio Bendandi, Larry W. Kwak, Stephen P. Creekmore
Publikováno v:
Nature Medicine. 5:1171-1177
Lymphomas express a tumor-specific antigen which can be targeted by cancer vaccination. We evaluated the ability of a new idiotype protein vaccine formulation to eradicate residual t(14;18)+ lymphoma cells in 20 patients in a homogeneous, chemotherap
Autor:
Larry W. Kwak, Carol B. Kobrin
Publikováno v:
Expert Opinion on Investigational Drugs. 3:1241-1253
First generation cancer vaccines are being tested for clinical efficacy in the management of metastatic melanoma, colon cancer and non-Hodgkin's lymphoma. Expectations are that more patients will respond to this mode of therapy, and that responders w
Human autologous tumor-specific T-cell responses induced by liposomal delivery of a lymphoma antigen
Autor:
Barry L. Gause, Richard J. Robb, Mircea C. Popescu, Sivasubramanian Baskar, Robin Pennington, Thelma M. Watson, Elaine S. Jaffe, Sattva S. Neelapu, Larry W. Kwak, Linda K. Harvey, Carol B. Kobrin, Andrea Robin Frye
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 10(24)
Purpose: The idiotype (Id) of the immunoglobulin on a given B-cell malignancy is a clonal marker that can serve as a tumor-specific antigen. We developed a novel vaccine formulation by incorporating Id protein with liposomal lymphokine that was more
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 166(4)
Human germinal center B cell tumors retain the ability of their nontransformed counterparts to somatically hypermutate Ig V genes by nucleotide substitution. Among a survey of 60 primary previously untreated, clonal, follicular lymphomas we have iden
Autor:
Carol B. Kobrin, Larry W. Kwak
Publikováno v:
Cancer investigation. 15(6)
INTRODUCTION Early observations suggesting some cancer patients can mount a therapeutic immune response to their own tumors (reviewed in Ref. 1) have supported long-standing efforts to develop immunotherapy regimens for the adjunct treatment of human