Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Carol B. Fox"'
Autor:
Mary Piotrowski, Allen J. Duplantier, Christine A. Strick, Brian D. Harvey, Mark J. Majchrzak, Cheryl Li, Patricia A. Seymour, Christopher J. Schmidt, Carol B. Fox, Alan H. Ganong, Larry C. James, F. David Tingley, Andres D. Ramirez, James T. Downs, Mihály Hajós, Victor Guanowsky, Liam Scott, Stacey L. Becker, Youfen Xu, Stefanus J. Steyn, Ayman El-Kattan, Brian Rago
Publikováno v:
Neuropharmacology. 61:1001-1015
Observations that N-Methyl-D-Aspartate (NMDA) antagonists produce symptoms in humans that are similar to those seen in schizophrenia have led to the current hypothesis that schizophrenia might result from NMDA receptor hypofunction. Inhibition of D-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d50eb849564a55d05e9986564219f8
https://doi.org/10.1016/j.neuropharm.2011.06.029
https://doi.org/10.1016/j.neuropharm.2011.06.029
Autor:
Carol B. Fox, Spiros Liras, Douglas S. Chapin, Frederick R. Nelson, Jayvardhan Pandit, Xinjun Hou, Christopher John Helal, John M. Humphrey, Christopher J. Schmidt, Thomas Allen Chappie, Kimberly F. Fennell, Frank S. Menniti, Zhijun Kang, Julia Cianfrogna, Judith A. Siuciak, Mary C. MacDougall, Kari R. Fonseca, Rebecca E. O’Connor, Lois K. Chenard, Eric S. Marr, Lorraine A. Lebel, Laura McDowell, Robert D. Williams
Publikováno v:
Journal of Medicinal Chemistry. 54:4536-4547
Utilizing structure-based virtual library design and scoring, a novel chimeric series of phosphodiesterase 10A (PDE10A) inhibitors was discovered by synergizing binding site interactions and ADME properties of two chemotypes. Virtual libraries were d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9470cb95f70a63260200b088b6fe12a3
https://doi.org/10.1021/jm2001508
https://doi.org/10.1021/jm2001508
Autor:
Christine A. Strick, Frank S. Menniti, Carol B. Fox, Larry C. James, Christopher J. Schmidt, Seeger Thomas Francis
Publikováno v:
Neuropharmacology. 58:444-451
PDE10A is a member of the phosphodiesterase superfamily highly enriched within medium spiny neurons (MSN) in mammalian striatum. We have used inhibitors of PDE10A and quantitative measures of mRNA to demonstrate that PDE10A controls striatal gene exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3701294c30456811f01c658ea8a3ec1a
https://doi.org/10.1016/j.neuropharm.2009.09.008
https://doi.org/10.1016/j.neuropharm.2009.09.008
Autor:
Martin Patrick Allen, Lorraine A. Lebel, Feng V. Yang, Christopher J. Schmidt, Spiros Liras, Kimberly G. Estep, Thomas Allen Chappie, Meihua Tu, Robert D. Williams, Carol B. Fox, Jayvardhan Pandit, John M. Humphrey, Frank S. Menniti, Eric S. Marr
Publikováno v:
Journal of Medicinal Chemistry. 50:182-185
A papaverine based pharmacophore model for PDE10A inhibition was generated via SBDD and used to design a library of 4-amino-6,7-dimethoxyquinazolines. From this library emerged an aryl ether pyrrolidyl 6,7-dimethoxyquinazoline series that became the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba095e31b13d59da670ef9e65938159
https://doi.org/10.1021/jm060653b
https://doi.org/10.1021/jm060653b
Autor:
Thomas I. Davis, Carol B. Fox, Michael C. Wirtz, Michael G. Vetelino, F. David Tingley, Krista E. Bianco, Robert S. Mansbach, David W. Schulz, Jotham Wadsworth Coe, Crystal G. Bashore, Hans Rollema, Eric P. Arnold, Paige Roanne Palmer Brooks, Steven B. Sands, Brian T. O’Neill, Lorraine A. Lebel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4889-4897
3,5-Bicyclic aryl piperidines are a new class of high-affinity alpha4beta2 nicotinic receptor agents. We have sought nicotinic receptor partial agonists of the alpha4beta2 nicotinic acetylcholine receptor for smoking cessation, and a number of compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04dfd8d682666f8daba933d872fb0b4a
https://doi.org/10.1016/j.bmcl.2005.08.035
https://doi.org/10.1016/j.bmcl.2005.08.035
Autor:
Yi Lu, Jotham Wadsworth Coe, Thomas I. Davis, David W. Schulz, Lorraine A. Lebel, Robert S. Mansbach, Paige Roanne Palmer Brooks, Michael C. Wirtz, Alka Shrikhande, Michael G. Vetelino, Leslie K. Chambers, Eric P. Arnold, Eric Schaeffer, Brian T. O’Neill, Steven B. Sands, and F. David Tingley, James Heym, Carol B. Fox, Huang Jianhua, Charles C. Rovetti, Hans Rollema
Publikováno v:
Modern Drug Synthesis
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine) has been identified for smoking cessation. Neuronal nicotinic acetylcholine receptors (nAChRs) mediate the dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d09a810f898eefeb7fda3442e4b30f
https://doi.org/10.1021/jm050069n
https://doi.org/10.1021/jm050069n
Autor:
Patricia A. Seymour, Desai Kishor A, B. Kenneth Koe, David H. Blank, Carol B. Fox, Macor John E, Anne W. Schmidt, David W. Schulz, Ronald J. Post, Lorraine A. Lebel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2391-2396
The discovery of CP-161,242 (5-cyano-1-[3-(N-methylpyrrolidin-2R-ylmethyl)indol-5-yl]benzimidazole), a potent, selective, orally active central serotonin (5-HT1D) agonist [IC50 (binding) = 1.3 nM, EC50 (inhibition of adenylate cyclase) = 42 pM] and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::babecb78f7d9c13cd636bdf0f868a836
https://doi.org/10.1016/0960-894x(95)00417-r
https://doi.org/10.1016/0960-894x(95)00417-r
Publikováno v:
Drug Development Research. 33:413-421
In the search for novel serotonin receptor ligands, a series of 5-thiazolyl-N,N-dimethyltryptamine derivatives was synthesized which exhibited high affinity binding to 5-HT1A, 5-HT1B, and 5-HT1D receptors and the functional characteristics of recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acbae4e9a5a75cd79c13560979a3c1a0
https://doi.org/10.1002/ddr.430330404
https://doi.org/10.1002/ddr.430330404
Autor:
Carol B. Fox, Ronald J. Post, Lorraine A. Lebel, Anne W. Schmidt, B. K. Koe, Macor John E, David W. Schulz, M. E. Newman, Kevin Ryan, David H. Blank
Publikováno v:
Journal of Medicinal Chemistry. 37:2509-2512
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f94900e523e56d2c94f8ed9df23d0f
https://doi.org/10.1021/jm00042a003
https://doi.org/10.1021/jm00042a003
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:91-94
Replacement of the phenol group in non-competitive NMDA antagonist ifenprodil with oxindole results in a new series of ′non-traditional′ NMDA antagonists. In combination with threo relative stereochemistry, improved NMDA antagonist potency and se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::725396b4aa512e14e0b59d444783efa8
https://doi.org/10.1016/s0960-894x(00)80098-0
https://doi.org/10.1016/s0960-894x(00)80098-0