Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Carol A. Witczak"'
Autor:
Florentina Negoita, Alex B. Addinsall, Kristina Hellberg, Conchita Fraguas Bringas, Paul S. Hafen, Tyler J. Sermersheim, Marianne Agerholm, Christopher T.A. Lewis, Danial Ahwazi, Naomi X.Y. Ling, Jeppe K. Larsen, Atul S. Deshmukh, Mohammad A. Hossain, Jonathan S. Oakhill, Julien Ochala, Jeffrey J. Brault, Uma Sankar, David H. Drewry, John W. Scott, Carol A. Witczak, Kei Sakamoto
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101761- (2023)
Objective: The AMP-activated protein kinase (AMPK) gets activated in response to energetic stress such as contractions and plays a vital role in regulating various metabolic processes such as insulin-independent glucose uptake in skeletal muscle. The
Externí odkaz:
https://doaj.org/article/9d5e5d0c7c7842288457d872e1ccedfc
Autor:
Melissa R. Iñigo, Adam J. Amorese, Michael D. Tarpey, Nicholas P. Balestrieri, Keith G. Jones, Daniel J. Patteson, Kathryn C. Jackson, Maria.J. Torres, Chien-Te Lin, Cody D. Smith, Timothy D. Heden, Shawna L. McMillin, Luke A. Weyrauch, Erin C. Stanley, Cameron A. Schmidt, Brita B. Kilburg-Basnyat, Sky W. Reece, Christine E. Psaltis, Leslie A. Leinwand, Katsu Funai, Joseph M. McClung, Kymberly M. Gowdy, Carol A. Witczak, Dawn A. Lowe, P. Darrell Neufer, Espen E. Spangenburg
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 1-15 (2020)
Objective: Estrogen receptor-α (ERα) is a nuclear receptor family member thought to substantially contribute to the metabolic regulation of skeletal muscle. However, previous mouse models utilized to assess the necessity of ERα signaling in skelet
Externí odkaz:
https://doaj.org/article/cef6092a71cd44739e7411b85eb621c4
Autor:
Shawna L. McMillin, Parker L. Evans, William M. Taylor, Luke A. Weyrauch, Tyler J. Sermersheim, Steven S. Welc, Monique R. Heitmeier, Richard C. Hresko, Paul W. Hruz, Francoise Koumanov, Geoffrey D. Holman, E. Dale Abel, Carol A. Witczak
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1734 (2022)
Glucose transporter 1 (GLUT1) is believed to solely mediate basal (insulin-independent) glucose uptake in skeletal muscle; yet recent work has demonstrated that mechanical overload, a model of resistance exercise training, increases muscle GLUT1 leve
Externí odkaz:
https://doaj.org/article/147a73ac6c2d4bab8a2344c5e3fe0de0
Autor:
Cody D. Smith, Cheryl A.S. Smith, Shawna L. McMillin, P. Darrell Neufer, Luke A. Weyrauch, Carol A. Witczak, Chein-Te Lin, Irwin J. Kurland, Cameron A. Schmidt
Publikováno v:
Am J Physiol Endocrinol Metab
Elevated mitochondrial hydrogen peroxide (H(2)O(2)) emission and an oxidative shift in cytosolic redox environment have been linked to high-fat-diet-induced insulin resistance in skeletal muscle. To test specifically whether increased flux through mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8fa8622d77fcd786f9ff1501e4fa35
https://doi.org/10.1152/ajpendo.00010.2021
https://doi.org/10.1152/ajpendo.00010.2021
Autor:
Dawn A. Lowe, Shawna L. McMillin, Joseph M. McClung, Luke A. Weyrauch, Chien-Te Lin, Leslie A. Leinwand, Timothy D. Heden, Cameron A. Schmidt, Carol A. Witczak, Christine E. Psaltis, Kymberly M. Gowdy, Kathryn C. Jackson, Adam J. Amorese, Erin C. Stanley, Espen E. Spangenburg, Brita B. Kilburg-Basnyat, Sky W Reece, Nicholas P. Balestrieri, Michael D. Tarpey, Melissa R. Iñigo, P. Darrell Neufer, Daniel J. Patteson, Keith G. Jones, Maria J. Torres, Katsuhiko Funai, Cody D. Smith
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 34, Iss, Pp 1-15 (2020)
Molecular Metabolism, Vol 34, Iss, Pp 1-15 (2020)
Objective Estrogen receptor-α (ERα) is a nuclear receptor family member thought to substantially contribute to the metabolic regulation of skeletal muscle. However, previous mouse models utilized to assess the necessity of ERα signaling in skeleta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acd25bfe14943d2595eb692a9f6dc5a
http://europepmc.org/articles/PMC6994285
http://europepmc.org/articles/PMC6994285
Autor:
Carol A. Witczak, Shawna L. McMillin, Jeffrey J. Brault, Luke A. Weyrauch, Erin C. Stanley, Barbara B. Kahn
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4913, p 4913 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences
Volume 22
Issue 9
Denervation rapidly induces insulin resistance (i.e., impairments in insulin-stimulated glucose uptake and signaling proteins) in skeletal muscle. Surprisingly, whether this metabolic derangement is long-lasting is presently not clear. The main goal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ced5fba25fa0d8d9883dcf476f5164
https://www.mdpi.com/1422-0067/22/9/4913
https://www.mdpi.com/1422-0067/22/9/4913
Autor:
Spencer G. Miller, Jeffrey J. Brault, Andrew S. Law, Thomas M. O’Connell, Paul S. Hafen, David L. Logsdon, Catherine B. Springer, Carol A. Witczak
Publikováno v:
Metabolism
Background Skeletal muscle atrophy, whether caused by chronic disease, acute critical illness, disuse or aging, is characterized by tissue-specific decrease in oxidative capacity and broad alterations in metabolism that contribute to functional decli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1ef0d06e5e3a3af1a1401b5c427d5b
https://pubmed.ncbi.nlm.nih.gov/34400216
https://pubmed.ncbi.nlm.nih.gov/34400216
Autor:
Joshua S. Morgan, Jeffrey J. Brault, Carol A. Witczak, Patrick R. Davis, Nicolas A. Verhoeven, David A. Tulis, Spencer G. Miller
Publikováno v:
Metabolism
Background Protein degradation is an energy-dependent process, requiring ATP at multiple steps. However, reports conflict as to the relationship between intracellular energetics and the rate of proteasome-mediated protein degradation. Methods To dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794ba5882f6c76b9bf3754261e027d20
https://pubmed.ncbi.nlm.nih.gov/32370945
https://pubmed.ncbi.nlm.nih.gov/32370945
Publikováno v:
Diabetes
GLUT4 is necessary for acute insulin- and contraction-induced skeletal muscle glucose uptake, but its role in chronic muscle loading (overload)-induced glucose uptake is unknown. Our goal was to determine whether GLUT4 is required for overload-induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3edd4cd89c15206f45fb93b3508933d
http://europepmc.org/articles/PMC5440020
http://europepmc.org/articles/PMC5440020
Publikováno v:
Nutrients
Nutrients, Vol 11, Iss 10, p 2432 (2019)
Nutrients, Vol 11, Iss 10, p 2432 (2019)
Aerobic exercise training and resistance exercise training are both well-known for their ability to improve human health; especially in individuals with type 2 diabetes. However, there are critical differences between these two main forms of exercise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec5a574def34994262f22f530a593d3
https://pubmed.ncbi.nlm.nih.gov/31614762
https://pubmed.ncbi.nlm.nih.gov/31614762