Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Carol A. Mulrooney"'
Autor:
Rachel Fearns, Qin Yu, Michael Foley, Paul Robert Fleming, Jeremy R. Duvall, Barbara Ludeke, Christina Scherer, Carol A. Mulrooney, Michelle Palmer, Maurice D. Lee, Karthick Vishwanathan, Sarah M. McLeod, Lynn VerPlank, Sebastian T. Le Quement
Publikováno v:
Antiviral Research. 131:19-25
Respiratory syncytial virus (RSV) infections affect millions of children and adults every year. Despite the significant disease burden, there are currently no safe and effective vaccines or therapeutics. We employed a replicon-based high throughput s
Autor:
Daniela Masi, Keila N. Crespo-Llado, Amanda K. Lukens, Roger C. Wiegand, Dyann F. Wirth, Ann Rowley, Jeremy R. Duvall, Richard W. Heidebrecht, Mark E. Fitzgerald, Michael Foley, Adelfa E. Serrano, Nobutaka Kato, Stuart L. Schreiber, Marion Mercier, Benito Munoz, Carol A. Mulrooney, Christina Scherer, Eamon Comer, Maurice D. Lee, Michelle Palmer, Giovanni Muncipinto, Jennifer A. Beaudoin
Publikováno v:
Journal of Medicinal Chemistry
Here, we describe medicinal chemistry that was accelerated by a diversity-oriented synthesis (DOS) pathway, and in vivo studies of our previously reported macrocyclic antimalarial agent that derived from the synthetic pathway. Structure–activity re
Autor:
Jeremy R. Duvall, Jacob K. Asiedu, Paul A. Clemons, Lisa A. Marcaurelle, Willmen Youngsaye, Andrea de Souza, Evan L. Mulligan, Nicola Tolliday, Sivaraman Dandapani, Lakshmi B. Akella, Dennis Moccia, Michael Quintin, David L. Lahr, Stephen Brudz, Philip Montgomery, Carol A. Mulrooney, Joshua A. Bittker
Publikováno v:
Journal of Computer-Aided Molecular Design. 27:455-468
Integration of flexible data-analysis tools with cheminformatics methods is a prerequisite for successful identification and validation of "hits" in high-throughput screening (HTS) campaigns. We have designed, developed, and implemented a suite of ro
Autor:
Carol A. Mulrooney, Morgan Welzel-O’Shea, Bérénice C. Lemercier, Edward B. Holson, Landon Durak, Sarathy Kesavan, Jeremy R. Duvall, Jingqiang Wei, Florence F. Wagner, Adrien Joliton, Laura M. Panko, Maurice D. Lee, Lisa A. Marcaurelle, Lakshmi B. Akella, Haibo Liu, Emeline L. Davoine, Jason T. Lowe, Méryl Thomas, Etienne J. Donckele, Michael Foley, Byung-Chul Suh, Giovanni Muncipinto, Ann Rowley, Jean-Charles Marie, Baudouin Gerard
Publikováno v:
The Journal of Organic Chemistry. 77:7187-7211
The synthesis and diversification of a densely functionalized azetidine ring system to gain access to a wide variety of fused, bridged, and spirocyclic ring systems is described. The in vitro physicochemical and pharmacokinetic properties of represen
Autor:
Patrick J. Carroll, Marisa C. Kozlowski, Barbara J. Morgan, Carol A. Mulrooney, Erin M. O'Brien
Publikováno v:
The Journal of Organic Chemistry. 75:57-68
An efficient and stereoselective total synthesis of the perylenequinone natural product hypocrellin A (1) is described. The key features include a potentially biomimetic 1,8-diketone aldol cyclization to set the centrochiral C7,C7'-stereochemistry, b
Autor:
Barbara J. Morgan, Erin M. O'Brien, Joshua S. Dickstein, Carol A. Mulrooney, Marisa C. Kozlowski
Publikováno v:
Organic Letters. 9:2441-2444
A palladium-catalyzed aromatic decarboxylation reaction has been developed. With electron-rich aromatic acids, the reaction proceeds efficiently under fairly mild conditions in good yields. The method was useful with complex functionalized substrates
Publikováno v:
Organic Letters. 9:385-388
[reaction: see text] An enantioselective synthesis of the chiral bisnaphthopyrone natural product nigerone is reported. The key step was an eight-step isomerization process to form the final natural product. The isomerization precursor was constructe
Autor:
Carol A. Mulrooney, Marisa C. Kozlowski, Osvaldo Gutierrez, John M. Curto, Joshua S. Dickstein
Publikováno v:
The Journal of organic chemistry. 78(10)
Mechanism studies of a mild palladium-catalyzed decarboxylation of aromatic carboxylic acids are described. In particular, reaction orders and activation parameters for the two stages of the transformation were determined. These studies guided develo
Autor:
Jingqiang Wei, Mark E. Fitzgerald, Lakshmi B. Akella, Lisa A. Marcaurelle, Anita Vrcic, Carol A. Mulrooney, Jeremy R. Duvall, Byung-Chul Suh
Publikováno v:
ACS combinatorial science. 14(2)
A build/couple/pair (B/C/P) strategy was employed to generate a library of 7936 stereochemically diverse 12-membered macrolactams. All 8 stereoisomers of a common linear amine precursor were elaborated to form the corresponding 8 stereoisomers of two
Publikováno v:
Total Synthesis of Natural Products ISBN: 9783642340642
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::262d7864440618041e45fd40fb96faf2
https://doi.org/10.1007/978-3-642-34065-9_7
https://doi.org/10.1007/978-3-642-34065-9_7