Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Carol A. Mercer"'
Autor:
Cai Zhang, Joonbae Seo, Kazutoshi Murakami, Esam S. B. Salem, Elise Bernhard, Vishnupriya J. Borra, Kwangmin Choi, Celvie L. Yuan, Calvin C. Chan, Xiaoting Chen, Taosheng Huang, Matthew T. Weirauch, Senad Divanovic, Nathan R. Qi, Hala Einakat Thomas, Carol A. Mercer, Haruhiko Siomi, Takahisa Nakamura
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The RNA-induced silencing complex (RISC) represses gene expression via micro-RNA guided mRNA silencing. Here, the authors show that RISC component Argonaute 2 in the liver regulates energy metabolism by inducing microRNAs that cause metabolic disrupt
Externí odkaz:
https://doaj.org/article/38c391e9f41444b882b89e0d90e18efc
Publikováno v:
Cell Reports, Vol 4, Iss 1, Pp 87-98 (2013)
Recently, we demonstrated that RPL5 and RPL11 act in a mutually dependent manner to inhibit Hdm2 and stabilize p53 following impaired ribosome biogenesis. Given that RPL5 and RPL11 form a preribosomal complex with noncoding 5S ribosomal RNA (rRNA) an
Externí odkaz:
https://doaj.org/article/283bdd4d6a254f408594748715e41e89
Autor:
Hala E. Thomas, Jack Rubinstein, Lowell B. Anthony, Carol A. Mercer, Xiaoyang Qi, Kakajan Komurov, David R. Plas, Hanan M. Dahche, Vinicius S. Carreira, Sheryl E. Koch, Kathleen LaSance, Mariah Worley, Min Jiang, Zhengtao Chu, Melissa A. Orr-Asman
Inhibition of mTOR signaling using the rapalog everolimus is an FDA-approved targeted therapy for patients with lung and gastroenteropancreatic neuroendocrine tumors (NET). However, patients eventually progress on treatment, highlighting the need for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64aae7793335e011bc4ba3984f311be0
https://doi.org/10.1158/1535-7163.c.6538789
https://doi.org/10.1158/1535-7163.c.6538789
Autor:
Hala E. Thomas, Jack Rubinstein, Lowell B. Anthony, Carol A. Mercer, Xiaoyang Qi, Kakajan Komurov, David R. Plas, Hanan M. Dahche, Vinicius S. Carreira, Sheryl E. Koch, Kathleen LaSance, Mariah Worley, Min Jiang, Zhengtao Chu, Melissa A. Orr-Asman
Table S1. CC-223-treated mice tend to develop less histopathologic lesions of the heart valves than either rapamycin- or placebo-treated mice. Figure S1. MLN0128 inhibited mTOR signaling in human pNET cell lines in a dose-dependent manner. Figure S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d90b178ee84c8bf4d1cc19a4cbef7c1
https://doi.org/10.1158/1535-7163.22507783
https://doi.org/10.1158/1535-7163.22507783
Autor:
Sara C. Kozma, George Thomas, Antonio Zorzano, Santiago Ramón y Cajal, Javier Hernandez-Losa, Hala Elnakat Thomas, María I. Hernández-Álvarez, Carol A. Mercer, Xuemei Ge, Sónia R. Veiga
Purpose: Hepatocellular carcinoma (HCC) ranks second in cancer mortality and has limited therapeutic options. We recently described the synergistic effect of allosteric and ATP-site competitive inhibitors against the mTOR for the treatment of HCC. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0ad089ce6b299477b221ca86fc51e6
https://doi.org/10.1158/1078-0432.c.6527447
https://doi.org/10.1158/1078-0432.c.6527447
Autor:
Sara C. Kozma, George Thomas, Antonio Zorzano, Santiago Ramón y Cajal, Javier Hernandez-Losa, Hala Elnakat Thomas, María I. Hernández-Álvarez, Carol A. Mercer, Xuemei Ge, Sónia R. Veiga
Supplementary data and supplementary table and figures Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3043942e42d4d3bbc5096e87a3ba33cb
https://doi.org/10.1158/1078-0432.22470176
https://doi.org/10.1158/1078-0432.22470176
Autor:
Susan M. Blaney, Brenda Weigel, Helen Chen, L. Austin Doyle, Peter J. Houghton, Darcy A. Krueger, Carol A. Mercer, George Thomas, Charlotte Ahern, Joel M. Reid, Alexander A. Vinks, Lars M. Wagner, John P. Perentesis, Maryam Fouladi
Supplemental Figure 1. Graph of IMC-A12 trough serum concentrations versus time.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b985670d0034ef45eca9969c9267b7d
https://doi.org/10.1158/1078-0432.22460369
https://doi.org/10.1158/1078-0432.22460369
Autor:
Susan M. Blaney, Brenda Weigel, Helen Chen, L. Austin Doyle, Peter J. Houghton, Darcy A. Krueger, Carol A. Mercer, George Thomas, Charlotte Ahern, Joel M. Reid, Alexander A. Vinks, Lars M. Wagner, John P. Perentesis, Maryam Fouladi
Supplemental Table 1. IMC-A12 trough serum concentrations during cycle 1 and cycle 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de4d674d20873bcf36007d1516b395e
https://doi.org/10.1158/1078-0432.22460366
https://doi.org/10.1158/1078-0432.22460366
Autor:
Susan M. Blaney, Brenda Weigel, Helen Chen, L. Austin Doyle, Peter J. Houghton, Darcy A. Krueger, Carol A. Mercer, George Thomas, Charlotte Ahern, Joel M. Reid, Alexander A. Vinks, Lars M. Wagner, John P. Perentesis, Maryam Fouladi
Purpose: To determine the MTD, dose-limiting toxicities (DLT), pharmacokinetics, and biologic effects of cixutumumab administered in combination with temsirolimus to children with refractory solid tumors.Experimental Design: Cixutumumab and temsiroli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df17789d0d1404ac383d00fe6dfb792f
https://doi.org/10.1158/1078-0432.c.6524471.v1
https://doi.org/10.1158/1078-0432.c.6524471.v1
Autor:
Angela F. Drew, Molly M. McFarland-Mancini, Nader Husseinzadeh, Nico Van Rooijen, Mingfu Zhou, Carol A. Mercer, Idit Isaacsohn, Toni M. Robinson-Smith
The tumor microenvironment is known to have a profound effect on tumor progression in a highly context-specific manner. We have investigated whether peritoneal inflammation plays a causative role in ovarian tumor metastasis, a poorly understood proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75793d086e7778074b015b1358e279e5
https://doi.org/10.1158/0008-5472.c.6495585.v1
https://doi.org/10.1158/0008-5472.c.6495585.v1