Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Carol A. Casey"'
Autor:
Sundararajan Mahalingam, Ramesh Bellamkonda, Kusum K. Kharbanda, Madan Kumar Arumugam, Vikas Kumar, Carol A. Casey, Lorenzo Leggio, Karuna Rasineni
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116595- (2024)
Fatty liver is the earliest response of the liver to excessive alcohol consumption. Previously we identified that chronic alcohol administration increases levels of stomach-derived hormone, ghrelin, which by reducing circulating insulin levels, ultim
Externí odkaz:
https://doaj.org/article/b9357bba242e491aa09ac86d028401a4
Autor:
Carol A. Casey, Amanda J. Macke, Ryan R. Gough, Artem N. Pachikov, Mary E. Morris, Paul G. Thomes, Jacy L. Kubik, Melissa S. Holzapfel, Armen Petrosyan
Publikováno v:
Hepatology Communications, Vol 6, Iss 2, Pp 374-388 (2022)
Previous work from our laboratories has identified multiple defects in endocytosis, protein trafficking, and secretion, along with altered Golgi function after alcohol administration. Manifestation of alcohol‐associated liver disease (ALD) is assoc
Externí odkaz:
https://doaj.org/article/5f87cd9e716049a49068b8f44d773699
Autor:
Artem N. Pachikov, Ryan R. Gough, Caroline E. Christy, Mary E. Morris, Carol A. Casey, Chad A. LaGrange, Ganapati Bhat, Anatoly V. Kubyshkin, Iryna I. Fomochkina, Evgeniya Y. Zyablitskaya, Tatiana P. Makalish, Elena P. Golubinskaya, Kateryna A. Davydenko, Sergey N. Eremenko, Jean-Jack M. Riethoven, Amith S. Maroli, Thomas S. Payne, Robert Powers, Alexander Y. Lushnikov, Amanda J. Macke, Armen Petrosyan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)
Abstract Background The development of persistent endoplasmic reticulum (ER) stress is one of the cornerstones of prostate carcinogenesis; however, the mechanism is missing. Also, alcohol is a physiological ER stress inducer, and the link between alc
Externí odkaz:
https://doaj.org/article/014d95164ca742678370b0c8e52e6e16
Publikováno v:
Cells, Vol 12, Iss 7, p 1013 (2023)
Background: Aggresomes are collections of intracellular protein aggregates. In liver cells of patients with alcoholic hepatitis, aggresomes appear histologically as cellular inclusions known as Mallory–Denk (M–D) bodies. The proteasome is a multi
Externí odkaz:
https://doaj.org/article/3112976093b54ead9b8af75528d30cc4
Publikováno v:
Biology, Vol 12, Iss 1, p 28 (2022)
Using a multiplatform and multiomics approach, we identified metabolites, lipids, proteins, and metabolic pathways that were altered in the liver after chronic ethanol administration. A functional enrichment analysis of the multiomics dataset reveale
Externí odkaz:
https://doaj.org/article/df88342238074b5ca847d2198ee635f5
Autor:
Karuna Rasineni, Clayton W. Jordan, Paul G. Thomes, Jacy L. Kubik, Elizabeth M. Staab, Sarah A. Sweeney, Geoffrey A. Talmon, Terrence M. Donohue, Mark A. McNiven, Kusum K. Kharbanda, Carol A. Casey
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Background: Fatty liver, a major health problem worldwide, is the earliest pathological change in the progression of alcohol-associated (AFL) and non-alcoholic fatty liver disease (NAFL). Though the causes of AFL and NAFL differ, both share similar h
Externí odkaz:
https://doaj.org/article/e8d23a2791004e61af185919d5388699
Autor:
Carol A. Casey, Terrence M. Donohue, Jr., Jacy L. Kubik, Vikas Kumar, Michael J. Naldrett, Nicholas T. Woods, Cole P. Frisbie, Mark A. McNiven, Paul G. Thomes
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100049- (2021)
Abstract: Lipid droplets (LDs) are composed of neutral lipids enclosed in a phospholipid monolayer, which harbors membrane-associated proteins that regulate LD functions. Despite the crucial role of LDs in lipid metabolism, remodeling of LD protein c
Externí odkaz:
https://doaj.org/article/6960739a40cb475bacb975168dd7143d
Autor:
Li Yang, Changqing Yang, Paul G. Thomes, Kusum K. Kharbanda, Carol A. Casey, Mark A. McNiven, Terrence M. Donohue
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
This review describes the influence of ethanol consumption on hepatic lipophagy, a selective form of autophagy during which fat-storing organelles known as lipid droplets (LDs) are degraded in lysosomes. During classical autophagy, also known as macr
Externí odkaz:
https://doaj.org/article/36e3b9441f6f4c62b0de1b0740931970
Autor:
Karuna Rasineni, Serene M. L. Lee, Benita L. McVicker, Natalia A. Osna, Carol A. Casey, Kusum K. Kharbanda
Publikováno v:
Biology, Vol 10, Iss 1, p 19 (2020)
Background: Work from our laboratory has shown that the ethanol-induced increase in apoptotic hepatocellular death is closely related to the impairment in the ability of the asialoglycoprotein receptor (ASGP-R) to remove neighboring apoptotic cells.
Externí odkaz:
https://doaj.org/article/3e43edfc08e8494c96a635b9f0fa098f
Autor:
Karuna Rasineni, Mukund P. Srinivasan, Appakalai N. Balamurugan, Bhupendra S. Kaphalia, Shaogui Wang, Wen-Xing Ding, Stephen J. Pandol, Aurelia Lugea, Liz Simon, Patricia E. Molina, Peter Gao, Carol A. Casey, Natalia A. Osna, Kusum K. Kharbanda
Publikováno v:
Biomolecules, Vol 10, Iss 5, p 669 (2020)
Chronic excessive alcohol use is a well-recognized risk factor for pancreatic dysfunction and pancreatitis development. Evidence from in vivo and in vitro studies indicates that the detrimental effects of alcohol on the pancreas are from the direct t
Externí odkaz:
https://doaj.org/article/19878899bdaf4365ad8e7fe4283c888d