Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Carol A. Barnes"'
Autor:
Andrew S. Fox, Daniel Holley, Peter Christiaan Klink, Spencer A. Arbuckle, Carol A. Barnes, Jörn Diedrichsen, Sze Chai Kwok, Colin Kyle, J. Andrew Pruszynski, Jakob Seidlitz, XuFeng Zhou, Russell A. Poldrack, Krzysztof J. Gorgolewski
Publikováno v:
NeuroImage, Vol 225, Iss , Pp 117518- (2021)
Animal neuroimaging studies can provide unique insights into brain structure and function, and can be leveraged to bridge the gap between animal and human neuroscience. In part, this power comes from the ability to combine mechanistic interventions w
Externí odkaz:
https://doaj.org/article/cbfa51bdb51a4a0f9b9b82036a0d6c36
Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies
Autor:
Joseph A. McQuail, Amy R. Dunn, Yaakov Stern, Carol A. Barnes, Gerd Kempermann, Peter R. Rapp, Catherine C. Kaczorowski, Thomas C. Foster
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2021)
The goal of this review article is to provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and function throughout life. We propose that forth
Externí odkaz:
https://doaj.org/article/36f44c766a3f4b158589d4ac6f731c19
Autor:
Gene E. Alexander, Lan Lin, Eriko S. Yoshimaru, Pradyumna K. Bharadwaj, Kaitlin L. Bergfield, Lan T. Hoang, Monica K. Chawla, Kewei Chen, James R. Moeller, Carol A. Barnes, Theodore P. Trouard
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Healthy human aging has been associated with brain atrophy in prefrontal and selective temporal regions, but reductions in other brain areas have been observed. We previously found regional covariance patterns of gray matter with magnetic resonance i
Externí odkaz:
https://doaj.org/article/55f80587afe64a78a364eb87e4457d1a
Autor:
Yang Zhou, Monica K. Chawla, Jose L. Rios-Monterrosa, Lingzhi Wang, Marc A. Zempare, Victor J. Hruby, Carol A. Barnes, Minying Cai
Publikováno v:
Molecules, Vol 26, Iss 20, p 6266 (2021)
Brain G-protein coupled receptors have been hypothesized to be potential targets for maintaining or restoring cognitive function in normal aged individuals or in patients with neurodegenerative disease. A number of recent reports suggest that activat
Externí odkaz:
https://doaj.org/article/e0712418a2494dacae45609da6fc65fe
Publikováno v:
Frontiers in Neuroanatomy, Vol 13 (2019)
Brain tissue contains autofluorescing elements that potentially impede accurate identification of neurons when visualized with fluorescent microscopy. Age-related accumulation of molecules with autofluorescent properties, such as lipofuscin, can poss
Externí odkaz:
https://doaj.org/article/ed326fc52a264aeb89e9270afeb53fa3
Autor:
Lee Ryan, Meredith Hay, Matt J. Huentelman, Audrey Duarte, Tatjana Rundek, Bonnie Levin, Anja Soldan, Corinne Pettigrew, Matthias R. Mehl, Carol A. Barnes
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
The current “one size fits all” approach to our cognitive aging population is not adequate to close the gap between cognitive health span and lifespan. In this review article, we present a novel model for understanding, preventing, and treating a
Externí odkaz:
https://doaj.org/article/1aef8d8a13de42989fd5426f19428d92
Autor:
Mari N. Willeman, Monica K. Chawla, Marc A. Zempare, Lauren A Biwer, Lan T. Hoang, Ajay R. Uprety, Megan C. Fitzhugh, Matthew De Both, Paul D. Coleman, Theodore P. Trouard, Gene E. Alexander, Kenneth D. Mitchell, Carol A. Barnes, Taben M. Hale, Matthew Huentelman
Publikováno v:
Physiological Reports, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Hypertension is a major health concern in the developed world, and its prevalence increases with advancing age. The impact of hypertension on the function of the renal and cardiovascular systems is well studied; however, its influence on the
Externí odkaz:
https://doaj.org/article/76adeb50b6b241eeacdba5989ffac95c
Autor:
Monica K. Chawla, Daniel T. Gray, Christie Nguyen, Harshaan Dhaliwal, Marc Zempare, Hiroyuki Okuno, Matthew J. Huentelman, Carol A. Barnes
Publikováno v:
Frontiers in Systems Neuroscience, Vol 12 (2018)
Immediate-early genes (IEGs) are rapidly and transiently induced following excitatory neuronal activity including maximal electroconvulsive shock treatment (ECT). The rapid RNA response can be blocked by the sodium channel antagonist tetrodotoxin (TT
Externí odkaz:
https://doaj.org/article/bc4516b6364248b8a40742c0cec01d43
Autor:
Lara Ianov, Matt De Both, Monica K. Chawla, Asha Rani, Andrew J. Kennedy, Ignazio Piras, Jeremy J. Day, Ashley Siniard, Ashok Kumar, J. David Sweatt, Carol A. Barnes, Matthew J. Huentelman, Thomas C. Foster
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
The current study employed next-generation RNA sequencing to examine gene expression differences related to brain aging, cognitive decline, and hippocampal subfields. Young and aged rats were trained on a spatial episodic memory task. Hippocampal reg
Externí odkaz:
https://doaj.org/article/7f174db43057465d9cea4d44290dcdc8
Autor:
Pengcheng Han, Megan Nielsen, Melissa Song, Junxiang Yin, Michele R. Permenter, Julie A. Vogt, James R. Engle, Brittany N. Dugger, Thomas G. Beach, Carol A. Barnes, Jiong Shi
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Pituitary adenylate cyclase activating polypeptide (PACAP) is associated with Alzheimer’s disease (AD), but its age-related effects are unknown. We chose the rhesus macaque due to its closeness to human anatomy and physiology. We examined four vari
Externí odkaz:
https://doaj.org/article/d42264711aa34e8ebaa39b094ac165fb