Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Carol A Feghali-Bostwick"'
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87754 (2014)
Systemic sclerosis (SSc) is characterized by excessive fibrosis of the skin and internal organs due to fibroblast proliferation and excessive production of extracellular matrix (ECM). We have shown that insulin-like growth factor binding protein (IGF
Externí odkaz:
https://doaj.org/article/86c7f3a668e748f7b69ef6a4b4366da7
Autor:
Ludivine Renaud, Carole L. Wilson, Robert Lafyatis, Lynn M. Schnapp, Carol A. Feghali-Bostwick
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110010- (2024)
Summary: Systemic sclerosis (SSc) is a chronic disease characterized by fibrosis and vascular abnormalities in the skin and internal organs, including the lung. SSc-associated pulmonary fibrosis (SSc-PF) is the leading cause of death in SSc patients.
Externí odkaz:
https://doaj.org/article/3edca46345f34936801569b0ae6d94ae
Autor:
Sravanthi Gundavarapu, Neerad C Mishra, Shashi P Singh, Raymond J Langley, Ali Imran Saeed, Carol A Feghali-Bostwick, J Michael McIntosh, Julie Hutt, Ramakrishna Hegde, Shilpa Buch, Mohan L Sopori
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77160 (2013)
Lung diseases such as chronic obstructive pulmonary disease (COPD), asthma, and lung infections are major causes of morbidity and mortality among HIV-infected patients even in the era of antiretroviral therapy (ART). Many of these diseases are strong
Externí odkaz:
https://doaj.org/article/f0f2d8fa80d6449ca974fa8503dda8ec
Autor:
Ximena D Ruiz, Logan R Mlakar, Yukie Yamaguchi, Yunyun Su, Adriana T Larregina, Joseph M Pilewski, Carol A Feghali-Bostwick
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43049 (2012)
Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in vario
Externí odkaz:
https://doaj.org/article/dba85066bd4644ba8bd49366d2d2ff9f
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48560 (2012)
Heightened production of collagen and other matrix proteins underlies the fibrotic phenotype of systemic sclerosis (SSc). Roscovitine is an inhibitor of cyclin-dependent kinases that promote cell cycling (CDK1, 2), neuronal development (CDK5) and con
Externí odkaz:
https://doaj.org/article/957b0e4eb9d44aa4893754a0b558bcfd
Autor:
Jianmin Xue, Bernadette R Gochuico, Ahmad Samer Alawad, Carol A Feghali-Bostwick, Imre Noth, Steven D Nathan, Glenn D Rosen, Ivan O Rosas, Sanja Dacic, Iclal Ocak, Carl R Fuhrman, Karen T Cuenco, Mary A Smith, Susan S Jacobs, Adriana Zeevi, Penelope A Morel, Joseph M Pilewski, Vincent G Valentine, Kevin F Gibson, Naftali Kaminski, Frank C Sciurba, Yingze Zhang, Steven R Duncan
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14715 (2011)
Idiopathic pulmonary fibrosis (IPF) is a progressive and medically refractory lung disease with a grim prognosis. Although the etiology of IPF remains perplexing, abnormal adaptive immune responses are evident in many afflicted patients. We hypothesi
Externí odkaz:
https://doaj.org/article/fd57d3b207be48d59937b9f6e749a878
Autor:
Kristy M. Waldrep, Jessalyn I. Rodgers, Sara M. Garrett, Bethany J. Wolf, Carol A. Feghali-Bostwick
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11234 (2023)
Pulmonary fibrosis (PF) associated with systemic sclerosis (SSc) results in significant morbidity and mortality. We previously reported that insulin-like growth factor-II (IGF-II) is overexpressed in lung tissues and fibroblasts from SSc patients, an
Externí odkaz:
https://doaj.org/article/e9053aa88eb248f9abd307ba083ea370
Autor:
Ludivine Renaud, Kristy M. Waldrep, Willian A. da Silveira, Joseph M. Pilewski, Carol A. Feghali-Bostwick
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3645 (2023)
Systemic sclerosis (SSc) is a connective tissue disorder that results in fibrosis of the skin and visceral organs. SSc-associated pulmonary fibrosis (SSc-PF) is the leading cause of death amongst SSc patients. Racial disparity is noted in SSc as Afri
Externí odkaz:
https://doaj.org/article/c10a4d48c96546d3a847744179901a2b
Autor:
Huanxing, Sun, Yangyang, Zhu, Hongyi, Pan, Xiaosong, Chen, Jenna L, Balestrini, TuKiet T, Lam, Jean E, Kanyo, Anne, Eichmann, Mridu, Gulati, Wassim H, Fares, Hanwen, Bai, Carol A, Feghali-Bostwick, Ye, Gan, Xueyan, Peng, Meagan W, Moore, Eric S, White, Parid, Sava, Anjelica L, Gonzalez, Yuwei, Cheng, Laura E, Niklason, Erica L, Herzog
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 68(5)
Fibrocytes are collagen-producing leukocytes that accumulate in patients with systemic sclerosis (SSc; scleroderma)-related interstitial lung disease (ILD) via unknown mechanisms that have been associated with altered expression of neuroimmune protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23b811d9f53684dc88de567f94994edb
https://pubmed.ncbi.nlm.nih.gov/26748676
https://pubmed.ncbi.nlm.nih.gov/26748676
Publikováno v:
The Journal of Immunology Author Choice
Idiopathic pulmonary fibrosis (IPF) is a common, progressive, and invariably lethal interstitial lung disease with no effective therapy. The key cell driving the development of fibrosis is the myofibroblast. Lipoxin A4 (LXA4) is an anti-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::379f90c2229c8c093b85e5dc9122ecd8
https://pubmed.ncbi.nlm.nih.gov/26276873
https://pubmed.ncbi.nlm.nih.gov/26276873