Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Carol, Schuurmans"'
Autor:
Yacine Touahri, Joseph Hanna, Nobuhiko Tachibana, Satoshi Okawa, Hedy Liu, Luke Ajay David, Thomas Olender, Lakshmy Vasan, Alissa Pak, Dhruv Nimesh Mehta, Vorapin Chinchalongporn, Anjali Balakrishnan, Robert Cantrup, Rajiv Dixit, Pierre Mattar, Fermisk Saleh, Yaroslav Ilnytskyy, Monzur Murshed, Paul E. Mains, Igor Kovalchuk, Julie L. Lefebvre, Hon S. Leong, Michel Cayouette, Chao Wang, Antonio del Sol, Marjorie Brand, Benjamin E. Reese, Carol Schuurmans
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114005- (2024)
Summary: The retina is exquisitely patterned, with neuronal somata positioned at regular intervals to completely sample the visual field. Here, we show that phosphatase and tensin homolog (Pten) controls starburst amacrine cell spacing by modulating
Externí odkaz:
https://doaj.org/article/1882f62fe92d4324a8d569020841d0d4
Autor:
Chiara Galante, Nicolás Marichal, Franciele Franco Scarante, Litsa Maria Ghayad, Youran Shi, Carol Schuurmans, Benedikt Berninger, Sophie Péron
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/202037b60efe40048c7b600df82fc4cd
Autor:
Chiara Galante, Nicolás Marichal, Franciele Franco Scarante, Litsa Maria Ghayad, Youran Shi, Carol Schuurmans, Benedikt Berninger, Sophie Péron
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The proneural transcription factor Achaete-scute complex-like 1 (Ascl1) is a major regulator of neural fate decisions, implicated both in neurogenesis and oligodendrogliogenesis. Focusing on its neurogenic activity, Ascl1 has been widely used to repr
Externí odkaz:
https://doaj.org/article/668005160f64403abd45312db5c36dfd
Autor:
Hussein Ghazale, EunJee Park, Lakshmy Vasan, James Mester, Fermisk Saleh, Andrea Trevisiol, Dawn Zinyk, Vorapin Chinchalongporn, Mingzhe Liu, Taylor Fleming, Oleksandr Prokopchuk, Natalia Klenin, Deborah Kurrasch, Maryam Faiz, Bojana Stefanovic, JoAnne McLaurin, Carol Schuurmans
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Direct neuronal reprogramming, the process whereby a terminally differentiated cell is converted into an induced neuron without traversing a pluripotent state, has tremendous therapeutic potential for a host of neurodegenerative diseases. While there
Externí odkaz:
https://doaj.org/article/0eb03c295a474e0c9abfd4326919866b
Autor:
Joseph Hanna, Luke Ajay David, Yacine Touahri, Taylor Fleming, Robert A. Screaton, Carol Schuurmans
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Vision commences in the retina with rod and cone photoreceptors that detect and convert light to electrical signals. The irreversible loss of photoreceptors due to neurodegenerative disease leads to visual impairment and blindness. Interventions now
Externí odkaz:
https://doaj.org/article/dbb91a1e1c6642ceb7f095a397d288c2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Direct neuronal reprogramming is an innovative new technology that involves the conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent state. The capacity to make new neurons in the brain, which previously was not
Externí odkaz:
https://doaj.org/article/f4fae7c260d64724ac75593636d7cae7
Autor:
Shiekh Tanveer Ahmad, Alexandra D. Rogers, Myra J. Chen, Rajiv Dixit, Lata Adnani, Luke S. Frankiw, Samuel O. Lawn, Michael D. Blough, Mana Alshehri, Wei Wu, Marco A. Marra, Stephen M. Robbins, J. Gregory Cairncross, Carol Schuurmans, Jennifer A. Chan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Although Capicua (Cic), a transcriptional repressor, is linked to cancer, little is known about its function in the non-diseased brain. Here, authors show that Cic is strongly expressed in astrocytic and neuronal lineage cells during development and
Externí odkaz:
https://doaj.org/article/7c701ae587344f44b0639d92de89cde9
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Historically, the mammalian brain was thought to lack stem cells as no new neurons were found to be made in adulthood. That dogma changed ∼25 years ago with the identification of neural stem cells (NSCs) in the adult rodent forebrain. However, unli
Externí odkaz:
https://doaj.org/article/ced23734baf04d6899d7ed160a31789f
Autor:
Anjali Balakrishnan, Lauren Belfiore, Tak-Ho Chu, Taylor Fleming, Rajiv Midha, Jeff Biernaskie, Carol Schuurmans
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2021)
Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self-repair, lifelong disability is common. New molecular and cellular insi
Externí odkaz:
https://doaj.org/article/a614774ec92247579386548c2e45cba1
Autor:
Vahid Hoghooghi, Alexandra L. Palmer, Ariana Frederick, Yulan Jiang, Jessica E. Merkens, Anjali Balakrishnan, Trisha M. Finlay, Anders Grubb, Efrat Levy, Paul Gordon, Frank R. Jirik, Minh Dang Nguyen, Carol Schuurmans, Frank Visser, Shannon E. Dunn, Shalina S. Ousman
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108236- (2020)
Summary: The cysteine protease inhibitor Cystatin C (CST3) is highly expressed in the brains of multiple sclerosis (MS) patients and C57BL/6J mice with experimental autoimmune encephalomyelitis (EAE; a model of MS), but its roles in the diseases are
Externí odkaz:
https://doaj.org/article/a4620914131449128eaa04ff10db8078