Common protein-coding variants influence the racing phenotype in galloping racehorse breeds

Autor: Haige Han, Beatrice A. McGivney, Lucy Allen, Dongyi Bai, Leanne R. Corduff, Gantulga Davaakhuu, Jargalsaikhan Davaasambuu, Dulguun Dorjgotov, Thomas J. Hall, Andrew J. Hemmings, Amy R. Holtby, Tuyatsetseg Jambal, Badarch Jargalsaikhan, Uyasakh Jargalsaikhan, Naveen K. Kadri, David E. MacHugh, Hubert Pausch, Carol Readhead, David Warburton, Manglai Dugarjaviin, Emmeline W. Hill

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)

A genome-wide analysis in galloping racehorse breeds identifies protein-altering genetic variants in a core set of genes that appear to determine attributes for racing, including muscle, neurobiological, and metabolic advantages.

Externí odkaz: https://doaj.org/article/7fbc0a34695b4f7c89fb29f0972dd8b3

Winter Air Pollution from Domestic Coal Fired Heating in Ulaanbaatar, Mongolia, Is Strongly Associated with a Major Seasonal Cyclic Decrease in Successful Fecundity

Autor: Hilary Ong, Emma Dickinson-Craig, Pia S. Pannaraj, Sumiya Davaa, Colleen Azen, James Harding, Tegshjargal Sereenendorj, Carol Readhead, David Warburton, Brigitta Szepesi, Chimedsuren Ochir, Jargalsaikhan Badarch, Samantha Hunter

Publikováno v: International Journal of Environmental Research and Public Health
Volume 18
Issue 5
International Journal of Environmental Research and Public Health, Vol 18, Iss 2750, p 2750 (2021)

Pollution of the environment is increasing and threatens the health and wellbeing of adults and children around the globe. The impact of air pollution on pulmonary and cardiovascular disease has been well documented, but it also has a deleterious eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed233f5ac75d283a2294c1c28af325a5
https://resolver.caltech.edu/CaltechAUTHORS:20210311-130748370

Generating Transgenic Mice by Lentiviral Transduction of Spermatozoa Followed by In Vitro Fertilization and Embryo Transfer

Autor: Anil, Chandrashekran, Colin, Casimir, Nick, Dibb, Carol, Readhead, Robert, Winston

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1448

Most transgenic technologies rely on the oocyte as a substrate for genetic modification. Transgenics animals are usually generated by the injection of the gene constructs (including lentiviruses encoding gene constructs or modified embryonic stem cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c3685f910951dda75c5024e29c460d31
https://pubmed.ncbi.nlm.nih.gov/27317176

Combinatorial Analysis of mRNA Expression Patterns in Mouse Embryos Using Hybridization Chain Reaction

Autor: Niles A. Pierce, Rusty Lansford, Carol Readhead, David Huss, Scott E. Fraser, Harry M. T. Choi

Multiplexed fluorescent hybridization chain reaction (HCR) and advanced imaging techniques can be used to evaluate combinatorial gene expression patterns in whole mouse embryos with unprecedented spatial resolution. Using HCR, DNA probes complementar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ad0af6e7032847f3bda2228b02bb0f
https://resolver.caltech.edu/CaltechAUTHORS:20150311-133810360

Myelin deficiencies visualized in vivo: Visually evoked potentials and T2-weighted magnetic resonance images of shiverer mutant and wild-type mice

Autor: Carol Readhead, John C. Wood, Timothy D. Hiltner, Scott E. Fraser, Melanie Martin, Russell E. Jacobs

Publikováno v: Journal of Neuroscience Research. 84:1716-1726

Visually evoked potentials (VEPs) and micro magnetic resonance imaging (micro MRI) are widely used as noninvasive techniques for diagnosis of central nervous system (CNS) diseases, especially myelin diseases, such as multiple sclerosis. Here we use t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87245ed384dace2847679c69f8257424
https://doi.org/10.1002/jnr.21086