Development of ISB 1442, a CD38 and CD47 bispecific biparatopic antibody innate cell modulator for the treatment of multiple myeloma.

Autor: Grandclément C; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Estoppey C; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Dheilly E; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Panagopoulou M; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Monney T; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Dreyfus C; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Loyau J; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Labanca V; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Drake A; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., De Angelis S; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Rubod A; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Frei J; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Caro LN; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Blein S; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Martini E; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Chimen M; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Matthes T; Haematology Service, Department of Oncology and Clinical Pathology Service, Department of Diagnostics, University Hospital Geneva, 1211, Geneva, Switzerland., Kaya Z; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Institute, University of Oxford, Oxford, UK., Edwards CM; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Institute, University of Oxford, Oxford, UK., Edwards JR; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Institute, University of Oxford, Oxford, UK., Menoret E; Nantes Université, Inserm, CNRS, Université d'Angers, CRCI2NA, Nantes, France., Kervoelen C; Nantes Université, Inserm, CNRS, Université d'Angers, CRCI2NA, Nantes, France., Pellat-Deceunynck C; Nantes Université, Inserm, CNRS, Université d'Angers, CRCI2NA, Nantes, France.; SIRIC ILIAD, Angers, Nantes, France., Moreau P; Nantes Université, Inserm, CNRS, Université d'Angers, CRCI2NA, Nantes, France.; SIRIC ILIAD, Angers, Nantes, France.; Service d'Hématologie Clinique, Unité d'Investigation Clinique, CHU, Nantes, France., Mbow ML; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Srivastava A; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Dyson MR; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Zhukovsky EA; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland., Perro M; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland. mario.perro@iginnovate.com., Sammicheli S; Ichnos Glenmark Innovation, Lausanne, CH, Switzerland. stefano.sammicheli@iginnovate.com.

Publikováno v: Nature communications [Nat Commun] 2024 Mar 06; Vol. 15 (1), pp. 2054. Date of Electronic Publication: 2024 Mar 06.

Conformational equilibria of light-activated rhodopsin in nanodiscs.

Autor: Van Eps N; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.; Jules Stein Eye Institute, University of California, Los Angeles, CA 90095., Caro LN; Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5S 1A8., Morizumi T; Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5S 1A8., Kusnetzow AK; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.; Jules Stein Eye Institute, University of California, Los Angeles, CA 90095., Szczepek M; Institut für Medizinische Physik und Biophysik, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Hofmann KP; Institut für Medizinische Physik und Biophysik, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Bayburt TH; Department of Biochemistry, University of Illinois at Urbana-Champaign, Champaign, IL 61801., Sligar SG; Department of Biochemistry, University of Illinois at Urbana-Champaign, Champaign, IL 61801., Ernst OP; Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5S 1A8; oliver.ernst@utoronto.ca hubbellw@jsei.ucla.edu.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8., Hubbell WL; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095; oliver.ernst@utoronto.ca hubbellw@jsei.ucla.edu.; Jules Stein Eye Institute, University of California, Los Angeles, CA 90095.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Apr 18; Vol. 114 (16), pp. E3268-E3275. Date of Electronic Publication: 2017 Apr 03.

Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.

Autor: Ploier B; Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA., Caro LN; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada M5S 1A8., Morizumi T; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada M5S 1A8., Pandey K; Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA., Pearring JN; Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA., Goren MA; Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA., Finnemann SC; Department of Biological Sciences, Center for Cancer, Genetic Diseases and Gene Regulation, Fordham University, Bronx, New York 10458, USA., Graumann J; Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA.; Weill Cornell Medicine-Qatar, Qatar Foundation, Education City P.O.Box 24144, Doha, State of Qatar., Arshavsky VY; Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA., Dittman JS; Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA., Ernst OP; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada M5S 1A8.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8., Menon AK; Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA.

Publikováno v: Nature communications [Nat Commun] 2016 Oct 03; Vol. 7, pp. 12832. Date of Electronic Publication: 2016 Oct 03.

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.

Autor: Kang Y; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA., Zhou XE; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA., Gao X; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA., He Y; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA., Liu W; Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA., Ishchenko A; Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, California 90089, USA., Barty A; Center for Free Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, 22607 Hamburg, Germany., White TA; Center for Free Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, 22607 Hamburg, Germany., Yefanov O; Center for Free Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, 22607 Hamburg, Germany., Han GW; Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, California 90089, USA., Xu Q; Joint Center for Structural Genomics, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California 94025, USA., de Waal PW; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA., Ke J; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA., Tan MH; 1] Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA [2] Department of Obstetrics &Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Zhang C; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA., Moeller A; The National Resource for Automated Molecular Microscopy, New York Structural Biology Center, New York, New York 10027, USA., West GM; Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA., Pascal BD; Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA., Van Eps N; Jules Stein Eye Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA., Caro LN; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Vishnivetskiy SA; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA., Lee RJ; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA., Suino-Powell KM; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA., Gu X; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA., Pal K; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA., Ma J; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA., Zhi X; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA., Boutet S; Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, Menlo Park, California 94025, USA., Williams GJ; Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, Menlo Park, California 94025, USA., Messerschmidt M; 1] Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, Menlo Park, California 94025, USA [2] BioXFEL, NSF Science and Technology Center, 700 Ellicott Street, Buffalo, New York 14203, USA., Gati C; Center for Free Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, 22607 Hamburg, Germany., Zatsepin NA; 1] Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA [2] Department of Physics, Arizona State University, Tempe, Arizona 85287, USA., Wang D; 1] Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA [2] Department of Physics, Arizona State University, Tempe, Arizona 85287, USA., James D; 1] Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA [2] Department of Physics, Arizona State University, Tempe, Arizona 85287, USA., Basu S; 1] Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA [2] Department of Physics, Arizona State University, Tempe, Arizona 85287, USA., Roy-Chowdhury S; 1] Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA [2] Department of Physics, Arizona State University, Tempe, Arizona 85287, USA., Conrad CE; Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA., Coe J; Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA., Liu H; 1] Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA [2] Beijing Computational Science Research Center, Haidian District, Beijing 10084, China., Lisova S; Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA., Kupitz C; 1] Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA [2] Department of Physics, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA., Grotjohann I; Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA., Fromme R; Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA., Jiang Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Tan M; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Yang H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Li J; Department of Obstetrics &Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Wang M; Swiss Light Source at Paul Scherrer Institute, CH-5232 Villigen, Switzerland., Zheng Z; Department of Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, California 90089, USA., Li D; School of Medicine and School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland., Howe N; School of Medicine and School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland., Zhao Y; 1] BioXFEL, NSF Science and Technology Center, 700 Ellicott Street, Buffalo, New York 14203, USA [2] Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA., Standfuss J; Laboratory of Biomolecular Research at Paul Scherrer Institute, CH-5232 Villigen, Switzerland., Diederichs K; Department of Biology, Universität Konstanz, 78457 Konstanz, Germany., Dong Y; Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China., Potter CS; The National Resource for Automated Molecular Microscopy, New York Structural Biology Center, New York, New York 10027, USA., Carragher B; The National Resource for Automated Molecular Microscopy, New York Structural Biology Center, New York, New York 10027, USA., Caffrey M; School of Medicine and School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland., Jiang H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Chapman HN; 1] Center for Free Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, 22607 Hamburg, Germany [2] Centre for Ultrafast Imaging, 22761 Hamburg, Germany., Spence JC; 1] Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA [2] Department of Physics, Arizona State University, Tempe, Arizona 85287, USA., Fromme P; Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA., Weierstall U; 1] Department of Chemistry and Biochemistry, and Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-1604, USA [2] Department of Physics, Arizona State University, Tempe, Arizona 85287, USA., Ernst OP; 1] Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Katritch V; Department of Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, California 90089, USA., Gurevich VV; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA., Griffin PR; Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA., Hubbell WL; Jules Stein Eye Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA., Stevens RC; 1] Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, California 90089, USA [2] Department of Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, California 90089, USA [3] iHuman Institute, ShanghaiTech University, 2F Building 6, 99 Haike Road, Pudong New District, Shanghai 201210, China., Cherezov V; Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, California 90089, USA., Melcher K; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA., Xu HE; 1] Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA [2] VARI-SIMM Center, Center for Structure and Function of Drug Targets, CAS-Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Publikováno v: Nature [Nature] 2015 Jul 30; Vol. 523 (7562), pp. 561-7. Date of Electronic Publication: 2015 Jul 22.

Ion channel reporter for monitoring the activity of engineered GPCRs.

Autor: Moreau CJ; Institut de Biologie Structurale (IBS), University of Grenoble Alpes, Grenoble, France; CNRS, IBS, LabEx ICST, Grenoble, France; CEA, IBS, Grenoble, France. Electronic address: christophe.moreau@ibs.fr., Niescierowicz K; Institut de Biologie Structurale (IBS), University of Grenoble Alpes, Grenoble, France; CNRS, IBS, LabEx ICST, Grenoble, France; CEA, IBS, Grenoble, France., Caro LN; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., Revilloud J; Institut de Biologie Structurale (IBS), University of Grenoble Alpes, Grenoble, France; CNRS, IBS, LabEx ICST, Grenoble, France; CEA, IBS, Grenoble, France., Vivaudou M; Institut de Biologie Structurale (IBS), University of Grenoble Alpes, Grenoble, France; CNRS, IBS, LabEx ICST, Grenoble, France; CEA, IBS, Grenoble, France. Electronic address: michel.vivaudou@ibs.fr.

Publikováno v: Methods in enzymology [Methods Enzymol] 2015; Vol. 556, pp. 425-54. Date of Electronic Publication: 2015 Mar 21.