Single-cell transcriptomic profiling reveals a pathogenic role of cytotoxic CD4 ⁺ T cells in giant cell arteritis.

Autor: Carmona EG; Institute of Parasitology and Biomedicine López-Neyra (IPBLN), Spanish National Research Council (CSIC), Granada, Spain; Systemic Autoimmune Diseases Unit, Hospital Universitario Clínico San Cecilio, Instituto de Investigación Biosanitaria de Granada ibs.GRANADA, Granada, Spain., Callejas-Rubio JL; Systemic Autoimmune Diseases Unit, Hospital Universitario Clínico San Cecilio, Instituto de Investigación Biosanitaria de Granada ibs.GRANADA, Granada, Spain., Raya E; Rheumatology Department, Hospital Universitario Clínico San Cecilio, Instituto de Investigación Biosanitaria de Granada ibs.GRANADA, Granada, Spain., Ríos-Fernández R; Systemic Autoimmune Diseases Unit, Hospital Universitario Clínico San Cecilio, Instituto de Investigación Biosanitaria de Granada ibs.GRANADA, Granada, Spain., Villanueva-Martín G; Institute of Parasitology and Biomedicine López-Neyra (IPBLN), Spanish National Research Council (CSIC), Granada, Spain., Cid MC; Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Hernández-Rodríguez J; Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Ballestar E; Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), Badalona, Barcelona, Spain., Timmermann B; Max Planck Institute for Molecular Genetics, Berlin, Germany., Ortego-Centeno N; Department of Medicine, University of Granada, Instituto de Investigación Biosanitaria de Granada ibs.GRANADA, Granada, Spain., Martín J; Institute of Parasitology and Biomedicine López-Neyra (IPBLN), Spanish National Research Council (CSIC), Granada, Spain., Márquez A; Institute of Parasitology and Biomedicine López-Neyra (IPBLN), Spanish National Research Council (CSIC), Granada, Spain. Electronic address: anamaort@ipb.csic.es.

Publikováno v: Journal of autoimmunity [J Autoimmun] 2024 Jan; Vol. 142, pp. 103124. Date of Electronic Publication: 2023 Nov 11.

Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.

Autor: Ortiz-Fernández L; Institute of Parasitology and Biomedicine 'López- Neyra', CSIC, Granada, Spain anamaort@ipb.csic.es lourdes@ipb.csic.es., Carmona EG; Institute of Parasitology and Biomedicine 'López- Neyra', CSIC, Granada, Spain.; Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria de Granada ibs.GRANADA, Granada, Spain., Kerick M; Institute of Parasitology and Biomedicine 'López- Neyra', CSIC, Granada, Spain., Lyons P; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Carmona FD; Departamento de Genética e Instituto de Biotecnología, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain.; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain., López Mejías R; Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Santander, Spain., Khor CC; Duke-NUS Medical School, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Grayson PC; Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, Maryland, USA., Tombetti E; Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Hospital, Milan, Italy.; Department of Biomedical and Clinical Sciences L. Sacco, Milan University, Milan, Italy., Jiang L; Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China.; Evidence-Based Medicine Center, Fudan University, Shanghai, China., Direskeneli H; Department of Internal Medicine, Division of Rheumatology, Marmara University, Faculty of Medicine, Istanbul, Turkey., Saruhan-Direskeneli G; Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey., Callejas-Rubio JL; Systemic Autoimmune Diseases Unit, San Cecilio University Hospital, Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain., Vaglio A; Department of Biomedical Experimental and Clinical Sciences 'Mario Serio', University of Florence, Florence, Italy.; Nephrology and Dialysis Unit, Meyer Children's Hospital, Florence, Italy., Salvarani C; Rheumatology Unit, Azienda USL-IRCCS di Reggio Emilia and Azienda Ospedaliero - Universitaria di Modena, Università di Modena and Reggio Emilia, Reggio Emilia, Italy., Hernández-Rodríguez J; Department of Autoimmune Diseases, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Cid MC; Department of Autoimmune Diseases, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Morgan AW; School of Medicine and Leeds Institute for Data Analytics, University of Leeds, Leeds, UK.; NIHR Leeds Biomedical Research Centre and NIHR Leeds Medtech and In vitro Diagnostics Co-Operative, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Merkel PA; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Division of Epidemiology, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Burgner D; Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.; Department of General Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.; Department of Paediatrics, Monash University, Clayton, Victoria, Australia., Smith KG; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Gonzalez-Gay MA; Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, University of Cantabria, Santander, Spain., Sawalha AH; Division of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Lupus Center of Excellence, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Martin J; Institute of Parasitology and Biomedicine 'López- Neyra', CSIC, Granada, Spain., Marquez A; Institute of Parasitology and Biomedicine 'López- Neyra', CSIC, Granada, Spain anamaort@ipb.csic.es lourdes@ipb.csic.es.

Publikováno v: Annals of the rheumatic diseases [Ann Rheum Dis] 2023 Jun; Vol. 82 (6), pp. 837-847. Date of Electronic Publication: 2023 Feb 16.

A TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility.

Autor: González-Serna D; Instituto de Parasitología y Biomedicina 'López-Neyra', CSIC, PTS Granada, Granada, Spain., Carmona EG; Instituto de Parasitología y Biomedicina 'López-Neyra', CSIC, PTS Granada, Granada, Spain., Ortego-Centeno N; Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain., Simeón CP; Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain., Solans R; Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain., Hernández-Rodríguez J; Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Tolosa C; Department of Internal Medicine, Hospital Parc Tauli, Sabadell, Spain., Castañeda S; Department of Rheumatology, Hospital de la Princesa, IIS-Princesa, Madrid, Spain., Narváez J; Department of Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain., Martinez-Valle F; Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain., Witte T; Hannover Medical School, Hannover, Germany., Neumann T; Klinik für Innere Medizin III, University-Hospital Jena, Jena, Germany., Holle J; Vasculitis Clinic, Klinikum Bad Bramstedt & University Hospital of Schleswig Holstein, Bad Bramstedt, Germany., Beretta L; Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy., Boiardi L; Rheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy., Emmi G; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Cimmino MA; Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy., Vaglio A; Department of Biomedical Experimental and Clinical Sciences 'Mario Serio', University of Firenze, Firenze, Italy.; Nephrology and Dialysis Unit, Meyer Children's University Hospital, Firenze, Italy., Herrick AL; Centre for Musculoskeletal Research and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Denton CP; Centre for Rheumatology, Royal Free and University College Medical School, London, UK., Salvarani C; Azienda USL-IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia, Reggio Emilia, Italy., Cid MC; Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Morgan AW; School of Medicine, University of Leeds and NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom., Fonseca C; Centre for Rheumatology, Royal Free and University College Medical School, London, UK., González-Gay MA; Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain., Martín J; Instituto de Parasitología y Biomedicina 'López-Neyra', CSIC, PTS Granada, Granada, Spain., Márquez A; Instituto de Parasitología y Biomedicina 'López-Neyra', CSIC, PTS Granada, Granada, Spain.; Systemic Autoimmune Disease Unit, Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.

Publikováno v: PloS one [PLoS One] 2018 Dec 26; Vol. 13 (12), pp. e0209343. Date of Electronic Publication: 2018 Dec 26 (Print Publication: 2018).