Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader.

Autor: Carmona AV; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68106, USA., Jonnalagadda S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68106, USA., Case AM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68106, USA., Maddeboina K; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68106, USA., Jonnalagadda SK; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68106, USA., Dow LF; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68106, USA., Duan L; Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA., Penning TM; Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA., Trippier PC; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68106, USA. paul.trippier@unmc.edu.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68106, USA. paul.trippier@unmc.edu.; UNMC Center for Drug Design and Innovation, University of Nebraska Medical Center, Omaha, NE, 68106, USA. paul.trippier@unmc.edu.

Publikováno v: Communications chemistry [Commun Chem] 2024 Apr 29; Vol. 7 (1), pp. 95. Date of Electronic Publication: 2024 Apr 29.

Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.

Autor: Kumari S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States., Carmona AV; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States., Tiwari AK; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, Ohio 43614, United States., Trippier PC; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.; UNMC Center for Drug Discovery, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Nov 12; Vol. 63 (21), pp. 12290-12358. Date of Electronic Publication: 2020 Aug 04.

Exogenous Flupirtine as Potential Treatment for CLN3 Disease.

Autor: Maalouf K; Department of Biochemistry and Molecular Genetics, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon., Makoukji J; Department of Biochemistry and Molecular Genetics, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon., Saab S; Department of Biochemistry and Molecular Genetics, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon., Makhoul NJ; Department of Biochemistry and Molecular Genetics, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon., Carmona AV; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-6120, USA., Kinarivala N; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA., Ghanem N; Department of Biology, American University of Beirut, Beirut 1107 2020, Lebanon., Trippier PC; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-6120, USA.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198-6120, USA.; UNMC Center for Drug Discovery, University of Nebraska Medical Center, Omaha, NE 68198-6120, USA., Boustany RM; Department of Biochemistry and Molecular Genetics, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.; Neurogenetics Program, AUBMC Special Kids Clinic, Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon.; Neurogenetics Program and Pediatric Neurology, Departments of Pediatrics, Adolescent Medicine and Biochemistry, American University of Beirut, P.O. Box 11-0236 Riad El Solh 1107 2020, Beirut 1107 2020, Lebanon.

Publikováno v: Cells [Cells] 2020 Aug 11; Vol. 9 (8). Date of Electronic Publication: 2020 Aug 11.