Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Carmine J. Coscia"'
Autor:
Victoria R. Rendell, Eunhae Kim, Shana Jagwani, Lubov A. Ezerskiy, Jason W. Hahn, Mariana M. Belcheva, Carmine J. Coscia, Robin Wesselschmidt, Joy Q He
Publikováno v:
Journal of Neurochemistry. 112:1431-1441
As embryonic stem cell-derived neural progenitors (NPs) have the potential to be used in cell replacement therapy, an understanding of the signaling mechanisms that regulate their terminal differentiation is imperative. In previous studies, we discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5cae126a065c42a77ed758a5a71f52
https://doi.org/10.1111/j.1471-4159.2009.06479.x
https://doi.org/10.1111/j.1471-4159.2009.06479.x
Autor:
Kari T. Chambers, John J. Pozek, Alexi Kiss, Yasmin Mohabbat, Carmine J. Coscia, Gregory P. McLennan, Mariana M. Belcheva, Laura M. Bohn, Mayumi Miyatake, Robert A. Moyer
Publikováno v:
Journal of Neurochemistry. 107:1753-1765
GTP binding regulatory protein (G protein)-coupled receptors can activate MAPK pathways via G protein-dependent and -independent mechanisms. However, the physiological outcomes correlated with the cellular signaling events are not as well characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8103046d90388765e7982bfe92c0d2ca
https://doi.org/10.1111/j.1471-4159.2008.05745.x
https://doi.org/10.1111/j.1471-4159.2008.05745.x
Publikováno v:
Journal of Neurochemistry. 46:1929-1935
Cannabimimetic drugs have been shown to inhibit adenylate cyclase activity in N18TG2 neuroblastoma cells. This investigation examines the possible role of opioid receptors in the cannabimimetic response. Opioid receptors of the delta subtype were fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d084ba45378391f8a424edb535d5570
https://doi.org/10.1111/j.1471-4159.1986.tb08515.x
https://doi.org/10.1111/j.1471-4159.1986.tb08515.x
Autor:
Alexi Kiss, Amy L. Clark, Jannie S. Serna, Mariana M. Belcheva, Jason W. Hahn, Paul D. Haas, Carmine J. Coscia
Publikováno v:
Journal of Biological Chemistry. 280:27662-27669
Acute mu and kappa opioids activate the ERK/MAPK phosphorylation cascade that represents an integral part of the signaling pathway of growth factors in astrocytes. By this cross-talk, opioids may impact neural development and plasticity among other b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e153d61f74e77c4499456f5d197fad9
https://doi.org/10.1074/jbc.m502593200
https://doi.org/10.1074/jbc.m502593200
Publikováno v:
Developmental Brain Research. 151:149-157
In addition to its use for heroin addiction pharmacotherapy in general, buprenorphine has advantages in treating maternal heroin abuse. To examine the gestational effects of buprenorphine on opioid receptor signaling, the [(35)S]-GTP gamma S in situ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ffe7f35faf47b5c5689743f81fe2d6
https://doi.org/10.1016/j.devbrainres.2004.05.002
https://doi.org/10.1016/j.devbrainres.2004.05.002
Publikováno v:
Molecular Pharmacology. 64:1391-1401
Astroglia are a principal target of long-term mu antiproliferative actions. The mitogen-activated protein (MAP) kinase known as extracellular signal-regulated kinase (ERK), is a key mediator of cell proliferation. In studies on the mechanism of short
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681c9ea6fa4774535e6b8a63f527f649
https://doi.org/10.1124/mol.64.6.1391
https://doi.org/10.1124/mol.64.6.1391
Autor:
Kym C. Tolman, Carmine J. Coscia, Robert J. McHale, Michael D. Parnes, Gail E. Thomas, Julie A. McLachlan, Frank E. Johnson, Wojciech T. Bem, Mariana M. Belcheva, Jacob Barg, A. Ho
Publikováno v:
Journal of Neurochemistry. 63:570-574
Mouse N18TG2 neuroblastoma and rat C6 glioma cell lines were injected into male nude mice, and the tumors were passaged serially. At each generation, tumors were analyzed for delta opioid binding using [3H][D-Ala2,D-Leu5]enkephalin and for sigma 1 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5f80bc1a5d34514694065910a4a6a7
https://doi.org/10.1046/j.1471-4159.1994.63020570.x
https://doi.org/10.1046/j.1471-4159.1994.63020570.x
Autor:
A. Gorodinsky, Rivka Levy, Zvi Vogel, Carmine J. Coscia, Mariana M. Belcheva, Jacob Barg, Robert J. McHale
Publikováno v:
Journal of Neurochemistry. 65:1481-1486
Endorphins, enkephalins, and synthetic or naturally occurring exogenous opiates have been shown to affect the proliferation of neural cells (for reviews, see McDowell and Kitchen, 1987; Hammer and Hauser, 1992; Zagon and Slotkin, 1992; Leslie, 1993).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6babba3f9b6b6514a73d10679b72d66
https://doi.org/10.1046/j.1471-4159.1995.65041481.x
https://doi.org/10.1046/j.1471-4159.1995.65041481.x
Autor:
Carmine J. Coscia, Mariana M. Belcheva
Publikováno v:
Neurosignals. 11:34-44
One of the most intriguing examples of cross talk between signaling systems is the interrelationship between G protein-coupled receptor and growth factor receptor pathways leading to activation of the ERK/MAP kinase phosphorylation cascade. This revi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5e5d778424016bf0232cbe0cbf9615
https://doi.org/10.1159/000057320
https://doi.org/10.1159/000057320
Publikováno v:
Journal of Neurochemistry. 74:574-581
Opioid receptors (ORs) are members of the heptahelical, G protein-coupled receptor (GPCR) family that are targets of endogenous opioid peptides as well as opiate alkaloids, such as morphine. Opioid effects on neural development primarily entail suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b50e746b7cec182388b98277518b66
https://doi.org/10.1046/j.1471-4159.2000.740574.x
https://doi.org/10.1046/j.1471-4159.2000.740574.x