Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Carmen Vigo-Pelfrey"'
Autor:
John H. Growdon, Roger M. Nitsch, Dale Schenk, Robert D. Moir, Christoph Hock, Werner Naser, Sidonie Golombowski, Konrad Beyreuther, Franz Müller-Spahn, Rudolph E. Tanzi, Ursula Mönning, Carmen Vigo-Pelfrey, Ashley M. Bush
Publikováno v:
European Neurology. 39:111-118
Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by progressive dementia that ultimately leads to death. Histopathological hallmarks of AD include brain amyloid deposits and neurofibrillary tangles. Major depressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ea7cfe0186bea2e39e5b3c6ae268b7
https://doi.org/10.1159/000007917
https://doi.org/10.1159/000007917
Autor:
Hans Basun, Ivan Lieberburg, Lars Lannfelt, Lars-Olof Wahlund, Carmen Vigo-Pelfrey, Bengt Winblad, Dale Schenk
Publikováno v:
Neuroscience Letters. 199:203-206
The neuropathological hallmarks of Alzheimer's disease (AD) are amyloid-containing plaques and neurofibrillary tangles. The main constituent of senile plaques is amyloid β-peptide (Aβ) and in recent years, pathogenic mutations in the amyloid precur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c620e6e1b2853eb98ae44d30dfb417df
https://doi.org/10.1016/0304-3940(95)12059-d
https://doi.org/10.1016/0304-3940(95)12059-d
Autor:
Janet A. Johnston, Christine Miller, Dennis J. Selkoe, Bengt Winblad, David B. Teplow, Dale Schenk, Lars Lannfelt, Nikolaos Venizelos, Carmen Vigo-Pelfrey, Martin Citron
Publikováno v:
Proceedings of the National Academy of Sciences. 91:11993-11997
The 39- to 43-amino acid amyloid beta-protein (A beta), which is progressively deposited in cerebral plaques and blood vessels in Alzheimer disease (AD), is secreted by cultured human cells during normal metabolism. In studies of cell lines transfect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41394b677356f4e94790e670853bf0e
https://doi.org/10.1073/pnas.91.25.11993
https://doi.org/10.1073/pnas.91.25.11993
Publikováno v:
Journal of Neurochemistry. 61:1965-1968
β-Amyloid peptide (Aβ) is one of the main components of senile plaques in the brain tissue of Alzheimer's disease (AD) patients. Aβ is proteolytically cleaved from the amyloid precursor protein (APP), an integral membrane protein possessing a larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd44e7bcea6e8c9329eb84cc5ff8514e
https://doi.org/10.1111/j.1471-4159.1993.tb09841.x
https://doi.org/10.1111/j.1471-4159.1993.tb09841.x
Autor:
Albert Y. Hung, Edward H. Koo, Beth L. Ostaszewski, A Mellon, Michael G. Schlossmacher, Ivan Lieberburg, Carmen Vigo-Pelfrey, Dale B. Schenk, Christian Haass, David B. Teplow
Publikováno v:
Nature. 359:322-325
Alzheimer's disease is characterized by the extracellular deposition in the brain and its blood vessels of insoluble aggregates of the amyloid beta-peptide (A beta), a fragment, of about 40 amino acids in length, of the integral membrane protein beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f932ba6340c9dae648ae9f3ebc519e17
https://doi.org/10.1038/359322a0
https://doi.org/10.1038/359322a0
Publikováno v:
Chemistry and Physics of Lipids. 53:91-101
Partially hydrogenated egg phosphatidylcholines (PHEPC) represent a new class of raw materials for liposome-based drug products. PHEPC were manufactured from native egge phosphatidylcholine (EPC) to iodine values (IV) 40, 30, 20, 10, and 1. Hydrogena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c100e868ae556faf7727bbae2eac57c
https://doi.org/10.1016/0009-3084(90)90137-g
https://doi.org/10.1016/0009-3084(90)90137-g
Autor:
Dennis J. Selkoe, Peter Seubert, Tilman Oltersdorf, Christian Haass, Ivan Lieberburg, Martin Citron, Lisa C. Mcconlogue, Albert Y. Hung, Carmen Vigo-Pelfrey
Publikováno v:
Nature. 360:672-674
Progressive cerebral deposition of the 39-43-amino-acid amyloid beta-protein (A beta) is an invariant feature of Alzheimer's disease which precedes symptoms of dementia by years or decades. The only specific molecular defects that cause Alzheimer's d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7668f74d83a62824cfc31cc899a9cac7
https://doi.org/10.1038/360672a0
https://doi.org/10.1038/360672a0
Autor:
Justine Whaley, Peter Seubert, Dennis J. Selkoe, Carmen Vigo-Pelfrey, Harry F. Dovey, Robert L. Wolfert, Robert T. McCormack, Sukanto Sinha, Dale Schenk, Cathy Swindlehurst, Frederick Esch, Michael Schiossmacher, Michael K. Lee, Dave Davis, Ivan Lieberburg
Publikováno v:
Nature. 359:325-327
CEREBRAL deposition of the β-amyloid peptide (Aβ) is an invariant feature of Alzheimer's disease. Since the original isola-tion and characterization of αβ (ref. 1) and the subsequent cloning of its precursor protein2–5, no direct evidence for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01c9504d5e5c54054f5d2a8204397239
https://doi.org/10.1038/359325a0
https://doi.org/10.1038/359325a0
Autor:
Timothy C. Kasunic, Joel B. Kirkpatrick, Mark R. Emmerling, Geoffrey Murdoch, Carmen Vigo-Pelfrey, Yu Min Kuo, Melvyn J. Ball, Alex E. Roher
Publikováno v:
The Journal of biological chemistry. 271(8)
Ultracentrifugation and graded molecular sieving, as well as a sensitive sandwich enzyme-linked immunosorbent assay were used to isolate and quantitate the amounts of water-soluble oligomers of beta amyloid (Abeta) peptides N-40 and N-42 in cerebral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117464e7180c2bcb96cf8ce238d2f9fe
https://pubmed.ncbi.nlm.nih.gov/8626743
https://pubmed.ncbi.nlm.nih.gov/8626743
Autor:
Peter Seubert, R. Wolfert, Kelly Johnson-Wood, R. Motter, Linda Chang, Dale Schenk, D. Olson, C. Clark, Carmen Vigo-Pelfrey, Bruce L. Miller, Doug R. Galasko, P. Southwick, Robin Barbour, B. Munroe, Robert C. Green, Dora Kholodenko, Ivan Lieberburg
Publikováno v:
Annals of neurology. 38(4)
In this clinical study the cerebrospinal fluid (CSF) level of a novel form of the beta-amyloid peptide (A beta) extending to position 42 (A beta 42) was determined in patients with Alzheimer's disease (AD) as well as controls. In addition to measurem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a84caba706cf9e37279384a8e3ecb6
https://pubmed.ncbi.nlm.nih.gov/7574461
https://pubmed.ncbi.nlm.nih.gov/7574461