Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Carmen S M Yong"'
Autor:
Irma Telarovic, Carmen S. M. Yong, Lisa Kurz, Irene Vetrugno, Sabrina Reichl, Alba Sanchez Fernandez, Hung-Wei Cheng, Rona Winkler, Matthias Guckenberger, Anja Kipar, Burkhard Ludewig, Martin Pruschy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Cancer resistance to immune checkpoint inhibitors motivated investigations into leveraging the immunostimulatory properties of radiotherapy to overcome immune evasion and to improve treatment response. However, clinical benefits of radiother
Externí odkaz:
https://doaj.org/article/5e4fb3861c2944398416dd9f676c87db
Autor:
Carmen S M Yong, Jennifer A Westwood, Jan Schröder, Anthony T Papenfuss, Bianca von Scheidt, Maria Moeller, Christel Devaud, Phillip K Darcy, Michael H Kershaw
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140543 (2015)
Genetically modified CD8+ T lymphocytes have shown significant anti-tumor effects in the adoptive immunotherapy of cancer, with recent studies highlighting a potential role for a combination of other immune subsets to enhance these results. However,
Externí odkaz:
https://doaj.org/article/d4ac0e1592d94aa2813a1758c4f98a4c
Autor:
Carmen S M Yong, Janelle Sharkey, Belinda Duscio, Ben Venville, Wei-Zen Wei, Richard F Jones, Clare Y Slaney, Gisela Mir Arnau, Anthony T Papenfuss, Jan Schröder, Phillip K Darcy, Michael H Kershaw
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136817 (2015)
The development of antigen-targeted therapeutics is dependent on the preferential expression of tumor-associated antigens (TAA) at targetable levels on the tumor. Tumor-associated antigens can be generated de novo or can arise from altered expression
Externí odkaz:
https://doaj.org/article/d6252cde6bfb4c0896fffc2848d364cc
Autor:
Christel Devaud, Carmen S M Yong, Liza B John, Jennifer A Westwood, Connie P M Duong, Colin M House, Delphine Denoyer, Jason Li, Phillip K Darcy, Michael H Kershaw
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108670 (2014)
The transcription factor Foxp3 represents the most specific functional marker of CD4+ regulatory T cells (TRegs). However, previous reports have described Foxp3 expression in other cell types including some subsets of macrophages, although there are
Externí odkaz:
https://doaj.org/article/63602a50307e4c50b64b3f50a833201c
Autor:
Connie P M Duong, Jennifer A Westwood, Carmen S M Yong, Amanda Murphy, Christel Devaud, Liza B John, Phillip K Darcy, Michael H Kershaw
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63037 (2013)
Genetic engineering of cellular function holds much promise for the treatment of a variety of diseases including gene deficiencies and cancer. However, engineering the full complement of cellular functions can be a daunting genetic exercise since man
Externí odkaz:
https://doaj.org/article/f6502717b8c9419d84271f81697cfaa1
Autor:
Julie Perrault, Anais Rivière, Chloe Goldsmith, Jonas Dehairs, Cédric Mongellaz, Laurent Yvan-Charvet, Naomi Taylor, Valérie S. Zimmermann, Saverio Tardito, Maria I. Matias, Valerie Dardalhon, Océane Delos, Amir Foroushani, Kandice R. Levental, Stefan A. Muljo, Sandrina Kinet, Ilya Levental, Hector Hernandez-Vargas, Ali Talebi, Jean-Charles Portais, Justine Bertand-Michel, Madeline Wong, Ameeta Kelekar, Julien C. Marie, Johannes V. Swinnen, Carmen S M Yong, Erdinc Sezgin
Publikováno v:
Cell Reports
Cell Reports, 2021, 37 (5), pp.109911. ⟨10.1016/j.celrep.2021.109911⟩
Cell Rep
Cell Reports, Vol 37, Iss 5, Pp 109911-(2021)
Cell Reports, 2021, 37 (5), pp.109911. ⟨10.1016/j.celrep.2021.109911⟩
Cell Rep
Cell Reports, Vol 37, Iss 5, Pp 109911-(2021)
Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic signaling pathways and intracellular metabolites. Here we show that cell-permeable α-ketoglutarate (αKG) alters the DNA methylation profile of naive CD4 T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a0285e83f2c785c903977fe07dec51
https://lirias.kuleuven.be/handle/20.500.12942/691431
https://lirias.kuleuven.be/handle/20.500.12942/691431
Autor:
Madeline Wong, Ilya Levental, Kandice R. Levental, Anais Rivière, Ali Talebi, Erdinc Sezgin, Naomi Taylor, Laurent Yvan-Charvet, Johannes V. Swinnen, Saverio Tardito, Valérie S. Zimmermann, Valerie Dardalhon, Stefan A. Muljo, Jonas Dehair, Amir Foroushani, Carmen S M Yong, Cédric Mongellaz, Sandrina Kinet, Maria I. Matias, Julie Perrault
Publikováno v:
SSRN Electronic Journal.
Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic signaling pathways. However, the impact of intracellular metabolites on Treg fate has not been well explored. Here we show that the α-ketoglutarate (αKG)
Autor:
Valerie Dardalhon, Sandrina Kinet, Naomi Taylor, Madeline Wong, J. Dehair, Ilya Levental, Erdinc Sezgin, Maria I. Matias, Cédric Mongellaz, Stefan A. Muljo, Valérie S. Zimmermann, Carmen S M Yong, Triantafyllos Chavakis, Johan Swinnen, Laurent Yvan-Charvet, Kandice R. Levental, Amir Foroushani, Saverio Tardito, Ali Talebi
The differentiation of CD4 T cells to a specific effector fate is metabolically regulated, integrating glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) with transcriptional and epigenetic changes. OXPHOS is tightly coordinated with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4a581548ca0aa1bcde00c6c0e039b91
https://doi.org/10.1101/2020.08.24.256560
https://doi.org/10.1101/2020.08.24.256560
Autor:
Valérie Dardalhon, Naomi Taylor, Daouda Abba Moussa, Gaspard Cretenet, Carmen S M Yong, Sandrina Kinet
Publikováno v:
FEBS Letters. 591:3104-3118
T cells are stimulated by the engagement of antigen, cytokine, pathogen, and hormone receptors. While research performed over many years has focused on deciphering the molecular components of these pathways, recent data underscore the importance of t
Autor:
Phillip K. Darcy, Carmen S M Yong, Michael H. Kershaw, Miles Prince, Ricky W. Johnstone, Joseph A. Trapani, Christel Devaud, Liza B John
Publikováno v:
Oncotarget
Oncotarget, Impact journals, 2016, 7 (23), pp.34582-34598. ⟨10.18632/oncotarget.9149⟩
Oncotarget, Impact journals, 2016, 7 (23), pp.34582-34598. ⟨10.18632/oncotarget.9149⟩
International audience; While adoptive immunotherapy using chimeric antigen receptor (CAR)-modified T cells can induce remission of some tumors, the role of other CAR-modified leukocytes is not well characterized. In this study, we characterize the f