Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Carmen Rodríguez-Cueto"'
Autor:
Claudia Gonzalo-Consuegra, Irene Santos-García, Laura García-Toscano, Raquel Martín-Baquero, Carmen Rodríguez-Cueto, Matthias B. Wittwer, Pawel Dzygiel, Uwe Grether, Eva de Lago, Javier Fernández-Ruiz
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116473- (2024)
Background: The elevation of endocannabinoid levels through inhibiting their degradation afforded neuroprotection in CaMKIIα-TDP-43 mice, a conditional transgenic model of frontotemporal dementia. However, which cannabinoid receptors are mediating t
Externí odkaz:
https://doaj.org/article/c348e372aa8949cf995edfd5d615612e
Autor:
Ignacio Silva-Llanes, Raquel Martín-Baquero, Alicia Berrojo-Armisen, Carmen Rodríguez-Cueto, Javier Fernández-Ruiz, Eva De Lago, Isabel Lastres-Becker
Publikováno v:
Antioxidants, Vol 13, Iss 9, p 1072 (2024)
Frontotemporal dementia (FTD) causes progressive neurodegeneration in the frontal and temporal lobes, leading to behavioral, cognitive, and language impairments. With no effective treatment available, exploring new therapeutic approaches is critical.
Externí odkaz:
https://doaj.org/article/8767a151d0124d85a60873b65cc5b01d
Autor:
Irene Santos-García, Carmen Rodríguez-Cueto, Patricia Villegas, Fabiana Piscitelli, Anna Lauritano, Che-Kun J. Shen, Vincenzo Di Marzo, Javier Fernández-Ruiz, Eva de Lago
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-32 (2023)
Abstract Background Frontotemporal dementia (FTD) is a heterogeneous group of early onset and progressive neurodegenerative disorders, characterized by degeneration in the frontal and temporal lobes, which causes deterioration in cognition, personali
Externí odkaz:
https://doaj.org/article/4032d4dbc13a42fda360381499239786
Autor:
María Gómez-Cañas, Paula Morales, Valentina Satta, Carmen Rodríguez-Cueto, Concepción García, Onintza Sagredo
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/bd1cd1d358f8481384f31afa98f338d5
Autor:
Sonia Burgaz, Concepción García, Claudia Gonzalo-Consuegra, Marta Gómez-Almería, Francisco Ruiz-Pino, Juan Diego Unciti, María Gómez-Cañas, Juan Alcalde, Paula Morales, Nadine Jagerovic, Carmen Rodríguez-Cueto, Eva de Lago, Eduardo Muñoz, Javier Fernández-Ruiz
Publikováno v:
Molecules, Vol 26, Iss 24, p 7643 (2021)
Cannabinoids act as pleiotropic compounds exerting, among others, a broad-spectrum of neuroprotective effects. These effects have been investigated in the last years in different preclinical models of neurodegeneration, with the cannabinoid type-1 (C
Externí odkaz:
https://doaj.org/article/4a88a818e83d475a8337cdef7ec47035
Autor:
Marta Gómez-Almería, Sonia Burgaz, Carlos Costas-Insua, Carmen Rodríguez-Cueto, Irene Santos-García, Ignacio Rodríguez-Crespo, Concepción García, Manuel Guzmán, Eva de Lago, Javier Fernández-Ruiz
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12533 (2021)
In the present study, we investigated the involvement of the chaperone protein BiP (also known as GRP78 or Hspa5), a master regulator of intracellular proteostasis, in two mouse models of neurodegenerative diseases: amyotrophic lateral sclerosis (ALS
Externí odkaz:
https://doaj.org/article/0596c9acd46f48c0a93625dc3145c5b7
Autor:
María Fernández-Trapero, Francisco Espejo-Porras, Carmen Rodríguez-Cueto, Joan R. Coates, Carmen Pérez-Díaz, Eva de Lago, Javier Fernández-Ruiz
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 5, Pp 551-558 (2017)
Targeting of the CB2 receptor results in neuroprotection in the SOD1G93A mutant mouse model of amyotrophic lateral sclerosis (ALS). The neuroprotective effects of CB2 receptors are facilitated by their upregulation in the spinal cord of the mutant mi
Externí odkaz:
https://doaj.org/article/a28310553cbf4198b0b270e471bcb1d0
Autor:
María Gómez-Ruiz, Carmen Rodríguez-Cueto, Eva Luna-Piñel, Mariluz Hernández-Gálvez, Javier Fernández-Ruiz
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Spinocerebellar ataxias (SCAs) are a group of hereditary and progressive neurological disorders characterized by a loss of balance and motor coordination typically associated with cerebellar atrophy. The most prevalent SCA types are all polyQ disorde
Externí odkaz:
https://doaj.org/article/49477ae53f414002978969ec472faf8c
Autor:
Carmen Rodríguez-Cueto, Mariluz Hernández-Gálvez, Cecilia J Hillard, Patricia Maciel, Sara Valdeolivas, José A Ramos, María Gómez-Ruiz, Javier Fernández-Ruiz
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176521 (2017)
Spinocerebellar ataxia type-3 (SCA-3) is the most prevalent autosomal dominant inherited ataxia. We recently found that the endocannabinoid system is altered in the post-mortem cerebellum of SCA-3 patients, and similar results were also found in the
Externí odkaz:
https://doaj.org/article/92f3615f440e4fba8be5af135934a229
Autor:
Gema Navarro, Paula Morales, Carmen Rodríguez-Cueto, Javier Fernández-Ruiz, Nadine Jagerovic, Rafael Franco
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
Endocannabinoids activate two types of specific receptors, namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions of agonists of CB1 receptors, and serious side effects of the selective antagonists of this receptor, drugs acting on CB2
Externí odkaz:
https://doaj.org/article/aad44e01b19d415fa58abbd0bca9006f