Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Carmen Pin"'
Autor:
Louis Gall, Ferran Jardi, Lieve Lammens, Janet Piñero, Terezinha M. Souza, Daniela Rodrigues, Danyel G. J. Jennen, Theo M. deKok, Luke Coyle, Seung‐Wook Chung, Sofia Ferreira, Heeseung Jo, Kylie A. Beattie, Colette Kelly, Carrie A. Duckworth, D. Mark Pritchard, Carmen Pin
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1511-1528 (2023)
Abstract We have built a quantitative systems toxicology modeling framework focused on the early prediction of oncotherapeutic‐induced clinical intestinal adverse effects. The model describes stem and progenitor cell dynamics in the small intestina
Externí odkaz:
https://doaj.org/article/ad07b2f07f9e481a9365795b33099f08
Autor:
Louis Gall, Carrie Duckworth, Ferran Jardi, Lieve Lammens, Aimee Parker, Ambra Bianco, Holly Kimko, David Mark Pritchard, Carmen Pin
Publikováno v:
eLife, Vol 12 (2023)
The maintenance of the functional integrity of the intestinal epithelium requires a tight coordination between cell production, migration, and shedding along the crypt–villus axis. Dysregulation of these processes may result in loss of the intestin
Externí odkaz:
https://doaj.org/article/018bbe6213294175aa395f530f4a00b7
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 9, Pp 498-508 (2020)
Stability analysis, often overlooked in pharmacometrics, is essential to explore dynamical systems. The model developed by Friberg et al.1 to describe drug‐induced hematotoxicity is widely used to support decisions across drug development, and para
Externí odkaz:
https://doaj.org/article/291292eba3d0466999335eab1b98cfea
Autor:
Chiara Fornari, Lenka Oplustil O'Connor, Carmen Pin, Aaron Smith, James W.T. Yates, S.Y. Amy Cheung, Duncan I. Jodrell, Jerome T. Mettetal, Teresa A. Collins
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 11, Pp 858-868 (2019)
Haematological toxicity associated with cancer therapeutics is monitored by changes in blood cell count, and their primary effect is on proliferative progenitors in the bone marrow. Using observations in rat bone marrow and blood, we characterize a m
Externí odkaz:
https://doaj.org/article/5848ecf4800c4426a41a4c13b85eb890
Autor:
Sarah McCallum, Yuuki Obata, Evangelia Fourli, Stefan Boeing, Christopher J Peddie, Qiling Xu, Stuart Horswell, Robert N Kelsh, Lucy Collinson, David Wilkinson, Carmen Pin, Vassilis Pachnis, Tiffany A Heanue
Publikováno v:
eLife, Vol 9 (2020)
The presence and identity of neural progenitors in the enteric nervous system (ENS) of vertebrates is a matter of intense debate. Here, we demonstrate that the non-neuronal ENS cell compartment of teleosts shares molecular and morphological character
Externí odkaz:
https://doaj.org/article/2e57d2f002cf475ba4153d7c9abee0b6
Autor:
Oliver J Maclaren, Aimée Parker, Carmen Pin, Simon R Carding, Alastair J M Watson, Alexander G Fletcher, Helen M Byrne, Philip K Maini
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 7, p e1005688 (2017)
Our work addresses two key challenges, one biological and one methodological. First, we aim to understand how proliferation and cell migration rates in the intestinal epithelium are related under healthy, damaged (Ara-C treated) and recovering condit
Externí odkaz:
https://doaj.org/article/c51090bb4d624b438d20bf4f061ad52c
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37115 (2012)
We developed a slow structural relaxation model to describe cellular dynamics in the crypt of the mouse small intestine. Cells are arranged in a three dimensional spiral the size of which dynamically changes according to cell production demands of ad
Externí odkaz:
https://doaj.org/article/956fda881b0840de8ee238e199c62d8d
Autor:
Carmen Pin, Trine Hansen, Marina Muñoz-Cuevas, Rob de Jonge, Jesper T Rosenkrantz, Charlotta Löfström, Henk Aarts, John E Olsen
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51196 (2012)
We investigated if the transcriptional response of Salmonella Typhimurium to temperature and acid variations was hysteretic, i.e. whether the transcriptional regulation caused by environmental stimuli showed memory and remained after the stimuli ceas
Externí odkaz:
https://doaj.org/article/8ee3bfbda01a4da792d1ebc8bd3ff77f
Autor:
Carmen Pineda, Ana I. Raya, Juan Morgaz, Raquel Sánchez‐Céspedes, Yolanda Millán, Escolástico Aguilera‐Tejero, Ignacio López
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 38, Iss 4, Pp 2257-2264 (2024)
Abstract Background Little information exists about vitamin D status in bitches with mammary tumors. Objectives To determine whether low plasma vitamin D concentrations are found in bitches with mammary tumors. Animals Eighty‐five client‐owned bi
Externí odkaz:
https://doaj.org/article/e6e31da490df4cffa443753717af65f9
Autor:
Louis Gall, Carrie Duckworth, Ferran Jardi, Lieve Lammens, Aimée Parker, Ambra Bianco, Holly Kimko, D. Mark Pritchard, Carmen Pin
We have built a multi-scale agent-based model (ABM) that reproduces the self-organizing behaviour reported for the intestinal crypt. We demonstrate that a stable spatial organization emerges from the dynamic interaction of multiple signalling pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7723905fe6385cda270248e71fa1440
https://doi.org/10.1101/2022.12.18.520934
https://doi.org/10.1101/2022.12.18.520934