Adherence to treatment with injectable immunomodulators in patients with multiple sclerosis and cognitive disorder

Autor: Irene Andrade Andrade, Elena Macías Cortés, Carmen Muñoz Fernández, Eduardo Tejedor Tejada, Magdalena Martínez Martínez

Publikováno v: Revista Científica de la Sociedad de Enfermería Neurológica (English ed.). 56:11-17

Introduction Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease that affects the central nervous system. Adherence to treatment is essential to modify the course of the disease. Cognitive impairment affects up to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16dab197960fa2cee581dcf9ce5de709
https://doi.org/10.1016/j.sedeng.2021.04.001

Early predictive risk factors for dimethyl fumarate-associated lymphopenia in patients with multiple sclerosis

Autor: Susana Sainz de la Maza, Julia Sabin Muñoz, Belén Pilo de la Fuente, Israel Thuissard, Cristina Andreu‑Vázquez, Victoria Galán Sánchez-Seco, Paula Salgado-Cámara, Lucienne Costa-Frossard, Enric Monreal, Lucía Ayuso-Peralta, Lorena García-Vasco, José Manuel García‑Domínguez, María Luisa Martínez-Ginés, Carmen Muñoz Fernández, Judit Díaz-Díaz, Celia Oreja-Guevara, Mayra Gómez‑Moreno, Hugo Martín, Laura Rubio-Flores, María Rosario Blasco, Luisa María Villar-Guimerans, Yolanda Aladro

Publikováno v: ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)

Background: Lymphopenia is a major concern in MS patients treated with dimethyl-fumarate (DMF) as it increases the risk of progressive multifocal leukoencephalopathy. A pronounced reduction in absolute lymphocyte counts (ALCs) early after treatment i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351d53ee8f221ec535d6ca75c5476ca3
https://hdl.handle.net/11268/11519

Anti-JC virus seroprevalence in a Spanish multiple sclerosis cohort

Autor: José Meca-Lallana, Rodrigo Terrero, Ricardo Ginestal, Elena Rodríguez-García, Carmen Muñoz-Fernández, Laura Borrego, Luis Felipe Díaz-Garzón, Jorge Millán, Lucía Ayuso, Clara de Andrés, María Cerdán, Mayra Gómez, Marta Cerezo, Israel Thuissard, Itziar Palmí, Cristina Guijarro, Yolanda Aladro, Virginia Meca-Lallana, Carlos López de Silanes, Ambrosio Miralles, Luisa Rubio, José M. García-Domínguez, M L Martínez-Ginés

Publikováno v: Journal of the Neurological Sciences. 365:16-21

Objective To estimate the seroprevalence of anti-JCV antibodies, seroconverting rates and evolution of antibody levels in a multiple sclerosis (MS) Spanish cohort. Methods Multicenter, retrospective cross-sectional and longitudinal study. The JCV ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfa594b92f89daf94b1c756eeebcbe3a
https://doi.org/10.1016/j.jns.2016.03.050

Anti-JC virus seroprevalence in a Spanish multiple sclerosis cohort: JC virus seroprevalence in Spain

Autor: Yolanda, Aladro, Rodrigo, Terrero, Marta, Cerezo, Ricardo, Ginestal, Lucía, Ayuso, Virginia, Meca-Lallana, Jorge, Millán, Laura, Borrego, Marisa, Martinez-Ginés, Luisa, Rubio, Clara, de Andrés, Ambrosio, Miralles, Cristina, Guijarro, Elena, Rodríguez-García, José Manuel, García-Dominguez, Carmen, Muñoz-Fernández, Carlos, López de Silanes, Mayra, Gómez, Israel, Thuissard, María, Cerdán, Itziar, Palmí, Luis Felipe, Díaz-Garzón, Jose, Meca-Lallana

Publikováno v: Journal of the neurological sciences. 365

To estimate the seroprevalence of anti-JCV antibodies, seroconverting rates and evolution of antibody levels in a multiple sclerosis (MS) Spanish cohort.Multicenter, retrospective cross-sectional and longitudinal study. The JCV seroprevalence was ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::911e7793f44c8ba6f47c583c5de4f059
https://pubmed.ncbi.nlm.nih.gov/27206867

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Autor: Itziar de Rojas, Sonia Moreno-Grau, Niccolo Tesi, Benjamin Grenier-Boley, Victor Andrade, Iris E. Jansen, Nancy L. Pedersen, Najada Stringa, Anna Zettergren, Isabel Hernández, Laura Montrreal, Carmen Antúnez, Anna Antonell, Rick M. Tankard, Joshua C. Bis, Rebecca Sims, Céline Bellenguez, Inés Quintela, Antonio González-Perez, Miguel Calero, Emilio Franco-Macías, Juan Macías, Rafael Blesa, Laura Cervera-Carles, Manuel Menéndez-González, Ana Frank-García, Jose Luís Royo, Fermin Moreno, Raquel Huerto Vilas, Miquel Baquero, Mónica Diez-Fairen, Carmen Lage, Sebastián García-Madrona, Pablo García-González, Emilio Alarcón-Martín, Sergi Valero, Oscar Sotolongo-Grau, Abbe Ullgren, Adam C. Naj, Afina W. Lemstra, Alba Benaque, Alba Pérez-Cordón, Alberto Benussi, Alberto Rábano, Alessandro Padovani, Alessio Squassina, Alexandre de Mendonça, Alfonso Arias Pastor, Almar A. L. Kok, Alun Meggy, Ana Belén Pastor, Ana Espinosa, Anaïs Corma-Gómez, Angel Martín Montes, Ángela Sanabria, Anita L. DeStefano, Anja Schneider, Annakaisa Haapasalo, Anne Kinhult Ståhlbom, Anne Tybjærg-Hansen, Annette M. Hartmann, Annika Spottke, Arturo Corbatón-Anchuelo, Arvid Rongve, Barbara Borroni, Beatrice Arosio, Benedetta Nacmias, Børge G. Nordestgaard, Brian W. Kunkle, Camille Charbonnier, Carla Abdelnour, Carlo Masullo, Carmen Martínez Rodríguez, Carmen Muñoz-Fernandez, Carole Dufouil, Caroline Graff, Catarina B. Ferreira, Caterina Chillotti, Chandra A. Reynolds, Chiara Fenoglio, Christine Van Broeckhoven, Christopher Clark, Claudia Pisanu, Claudia L. Satizabal, Clive Holmes, Dolores Buiza-Rueda, Dag Aarsland, Dan Rujescu, Daniel Alcolea, Daniela Galimberti, David Wallon, Davide Seripa, Edna Grünblatt, Efthimios Dardiotis, Emrah Düzel, Elio Scarpini, Elisa Conti, Elisa Rubino, Ellen Gelpi, Eloy Rodriguez-Rodriguez, Emmanuelle Duron, Eric Boerwinkle, Evelyn Ferri, Fabrizio Tagliavini, Fahri Küçükali, Florence Pasquier, Florentino Sanchez-Garcia, Francesca Mangialasche, Frank Jessen, Gaël Nicolas, Geir Selbæk, Gemma Ortega, Geneviève Chêne, Georgios Hadjigeorgiou, Giacomina Rossi, Gianfranco Spalletta, Giorgio Giaccone, Giulia Grande, Giuliano Binetti, Goran Papenberg, Harald Hampel, Henri Bailly, Henrik Zetterberg, Hilkka Soininen, Ida K. Karlsson, Ignacio Alvarez, Ildebrando Appollonio, Ina Giegling, Ingmar Skoog, Ingvild Saltvedt, Innocenzo Rainero, Irene Rosas Allende, Jakub Hort, Janine Diehl-Schmid, Jasper Van Dongen, Jean-Sebastien Vidal, Jenni Lehtisalo, Jens Wiltfang, Jesper Qvist Thomassen, Johannes Kornhuber, Jonathan L. Haines, Jonathan Vogelgsang, Juan A. Pineda, Juan Fortea, Julius Popp, Jürgen Deckert, Katharina Buerger, Kevin Morgan, Klaus Fließbach, Kristel Sleegers, Laura Molina-Porcel, Lena Kilander, Leonie Weinhold, Lindsay A. Farrer, Li-San Wang, Luca Kleineidam, Lucia Farotti, Lucilla Parnetti, Lucio Tremolizzo, Lucrezia Hausner, Luisa Benussi, Lutz Froelich, M. Arfan Ikram, M. Candida Deniz-Naranjo, Magda Tsolaki, Maitée Rosende-Roca, Malin Löwenmark, Marc Hulsman, Marco Spallazzi, Margaret A. Pericak-Vance, Margaret Esiri, María Bernal Sánchez-Arjona, Maria Carolina Dalmasso, María Teresa Martínez-Larrad, Marina Arcaro, Markus M. Nöthen, Marta Fernández-Fuertes, Martin Dichgans, Martin Ingelsson, Martin J. Herrmann, Martin Scherer, Martin Vyhnalek, Mary H. Kosmidis, Mary Yannakoulia, Matthias Schmid, Michael Ewers, Michael T. Heneka, Michael Wagner, Michela Scamosci, Miia Kivipelto, Mikko Hiltunen, Miren Zulaica, Montserrat Alegret, Myriam Fornage, Natalia Roberto, Natasja M. van Schoor, Nazib M. Seidu, Nerisa Banaj, Nicola J. Armstrong, Nikolaos Scarmeas, Norbert Scherbaum, Oliver Goldhardt, Oliver Hanon, Oliver Peters, Olivia Anna Skrobot, Olivier Quenez, Ondrej Lerch, Paola Bossù, Paolo Caffarra, Paolo Dionigi Rossi, Paraskevi Sakka, Per Hoffmann, Peter A. Holmans, Peter Fischer, Peter Riederer, Qiong Yang, Rachel Marshall, Rajesh N. Kalaria, Richard Mayeux, Rik Vandenberghe, Roberta Cecchetti, Roberta Ghidoni, Ruth Frikke-Schmidt, Sandro Sorbi, Sara Hägg, Sebastiaan Engelborghs, Seppo Helisalmi, Sigrid Botne Sando, Silke Kern, Silvana Archetti, Silvia Boschi, Silvia Fostinelli, Silvia Gil, Silvia Mendoza, Simon Mead, Simona Ciccone, Srdjan Djurovic, Stefanie Heilmann-Heimbach, Steffi Riedel-Heller, Teemu Kuulasmaa, Teodoro del Ser, Thibaud Lebouvier, Thomas Polak, Tiia Ngandu, Timo Grimmer, Valentina Bessi, Valentina Escott-Price, Vilmantas Giedraitis, Vincent Deramecourt, Wolfgang Maier, Xueqiu Jian, Yolande A. L. Pijnenburg, EADB contributors, DEGESCO consortium, IGAP (ADGC, CHARGE, EADI, GERAD), PGC-ALZ consortia, Patrick Gavin Kehoe, Guillermo Garcia-Ribas, Pascual Sánchez-Juan, Pau Pastor, Jordi Pérez-Tur, Gerard Piñol-Ripoll, Adolfo Lopez de Munain, Jose María García-Alberca, María J. Bullido, Victoria Álvarez, Alberto Lleó, Luis M. Real, Pablo Mir, Miguel Medina, Philip Scheltens, Henne Holstege, Marta Marquié, María Eugenia Sáez, Ángel Carracedo, Philippe Amouyel, Gerard D. Schellenberg, Julie Williams, Sudha Seshadri, Cornelia M. van Duijn, Karen A. Mather, Raquel Sánchez-Valle, Manuel Serrano-Ríos, Adelina Orellana, Lluís Tárraga, Kaj Blennow, Martijn Huisman, Ole A. Andreassen, Danielle Posthuma, Jordi Clarimón, Mercè Boada, Wiesje M. van der Flier, Alfredo Ramirez, Jean-Charles Lambert, Sven J. van der Lee, Agustín Ruiz

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy

Externí odkaz: https://doaj.org/article/3baab8412752494a9ff0927d1cfb9b68