KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain

Autor: Michal Lipinski, Rafael Muñoz-Viana, Beatriz del Blanco, Angel Marquez-Galera, Juan Medrano-Relinque, José M. Caramés, Andrzej A. Szczepankiewicz, Jordi Fernandez-Albert, Carmen M. Navarrón, Roman Olivares, Grzegorz M. Wilczyński, Santiago Canals, Jose P. Lopez-Atalaya, Angel Barco

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

Neuronal identity maintenance is highly regulated. Here, the authors showed that CBP and p300 safeguard neuronal identity through histone acetylation at promoters and enhancers of neuronal specific genes. The loss of both CBP and p300 impairs gene ex

Externí odkaz: https://doaj.org/article/8d6aa25253f747418d7750e6dad126ba

Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis

Autor: Aixa V. Morales, Yasunori Hayashi, Liset Menendez de la Prida, Masaaki Sato, Beatriz Gal, José P. López-Atalaya, Ivan Fernandez-Lamo, Angel Barco, Carmen M. Navarrón, Rita Reig-Viader, Manuel Valero, Angel Marquez-Galera, Daniel C. Medeiros, Elena Cid, Luis Ballesteros-Esteban, Daniel Gomez-Dominguez, Àlex Bayés

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Reports
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
CELL REPORTS
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante

Hippocampal sclerosis, the major neuropathological hallmark of temporal lobe epilepsy, is characterized by different patterns of neuronal loss. The mechanisms of cell-type-specific vulnerability and their progression and histopathological classificat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029cfb066d24de6da3469019f9c0cd0b
https://doi.org/10.1101/2021.02.03.429560

Neuronal identity is maintained in the adult brain through KAT3-dependent enhancer acetylation

Autor: Andrzej A. Szczepankiewicz, Angel Barco, Rafael Muñoz-Viana, Santiago Canals, Carmen M. Navarrón, Grzegorz M. Wilczynski, José P. López-Atalaya, Beatriz del Blanco, Román Olivares, Jordi Fernandez-Albert, Michal Lipinski, Juan Medrano-Relinque, José M. Caramés, Angel Marquez-Galera

Very little is known about the mechanisms responsible for maintaining cell identity in mature tissues. The paralogous type 3 lysine acetyltransferases (KAT3) CBP and p300 are both essential during development, but their specific functions in nondivid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cfe0311489d9cfc557de9792dc21bc3
https://doi.org/10.1101/836981

Cell-specific vulnerability to metabolic failure: the crucial role of parvalbumin expressing neurons in creatine transporter deficiency

Autor: Elsa Ghirardini, Giulia Sagona, Angel Marquez-Galera, Francesco Calugi, Carmen M. Navarron, Francesco Cacciante, Siwei Chen, Federica Di Vetta, Lorenzo Dadà, Raffaele Mazziotti, Leonardo Lupori, Elena Putignano, Pierre Baldi, Jose P. Lopez-Atalaya, Tommaso Pizzorusso, Laura Baroncelli

Publikováno v: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)

Abstract Mutations in the solute carrier family 6-member 8 (Slc6a8) gene, encoding the protein responsible for cellular creatine (Cr) uptake, cause Creatine Transporter Deficiency (CTD), an X-linked neurometabolic disorder presenting with intellectua

Externí odkaz: https://doaj.org/article/3f49e5cb2fdd44aa8c6228ed37b9bcba

Administration of cannabidiol reduced reinforcement, motivation and relapse to alcohol

Autor: Ana Isabel Torres-Suárez, Adrián Viudez-Martínez, Jorge Manzanares, María Salud García-Gutiérrez, M. Morales-Calero, Carmen M. Navarrón, Francisco Navarrete

Publikováno v: European Neuropsychopharmacology. 26:S670-S671

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b01799a8defd87a71c725304798ea29d
https://doi.org/10.1016/s0924-977x(16)31786-2