Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Carmen M. Baldino"'
Autor:
Eriko, Katsuta, Malgorzata, Gil-Moore, Justine, Moore, Mohamed, Yousif, Alex A, Adjei, Yi, Ding, Justin, Caserta, Carmen M, Baldino, Kelvin P, Lee, Irwin H, Gelman, Kazuaki, Takabe, Mateusz, Opyrchal
Publikováno v:
International Journal of Oncology. 61
Proviral integration of Moloney virus 2 (PIM2) is a pro‑survival factor of cancer cells and a possible therapeutic target in hematological malignancies. However, the attempts at inhibiting PIM2 have yielded underwhelming results in early clinical t
Autor:
Gerald J. Fetterly, K Bezbatchenko, Mateusz Opyrchal, Kelvin P. Lee, R Mehta, Carmen M. Baldino, Justin Caserta, Malgorzata Gil, D Kothai Guruswamy Sangameswaran, A. A. Adjei, J Moore, Thaer Khoury
Publikováno v:
Cancer Research. 77:P6-11
Background: Triple negative breast cancer (TNBC) patients have poorer prognosis and there remains a lack of novel targeted therapies for their treatment. PIM2 (Proviral Integrations of Moloney virus 2) belongs to a family of three kinases that have b
Autor:
Robb Nicewonger, Michael Baldino, Stephane Dumas, Chee-Seng Lee, Carmen M. Baldino, Justin Caserta, Yvonne Flanders
Publikováno v:
Tetrahedron Letters. 56:3186-3190
Herein, we describe the versatile synthesis of (Z)-5-((2-aminopyrimidin-4-yl)methylene)thiazolidine-2,4-dione inhibitors (1) of the PIM family of kinases. This chemistry strategy was a key element in the multi-variable optimization program with the g
Autor:
Gerald J. Fetterly, K Belko, T Howell, Kelvin P. Lee, Carmen M. Baldino, Jayakumar R. Nair, Justin Caserta
Publikováno v:
Leukemia
The PIM kinase family (PIM1, 2 and 3) have a central role in integrating growth and survival signals, and are expressed in a wide range of solid and hematological malignancies. We now confirm that PIM2 is overexpressed in multiple myeloma (MM) patien
ChemInform Abstract: A Versatile Synthesis of Novel pan-PIM Kinase Inhibitors with Initial SAR Study
Autor:
Michael Baldino, Robb Nicewonger, Chee-Seng Lee, Carmen M. Baldino, Yvonne Flanders, Justin Caserta, Stephane Dumas
Publikováno v:
ChemInform. 46
Herein, we describe the versatile synthesis of (Z)-5-((2-aminopyrimidin-4-yl)methylene)thiazolidine-2,4-dione inhibitors (1) of the PIM family of kinases. This chemistry strategy was a key element in the multi-variable optimization program with the g
Autor:
Jifeng Liu, Grace Bi, Mira Kaselj, Bailin Zhang, Daniel Yohannes, Carmen M. Baldino, Libing Yu, Yuko Isome, Jennifer Chapnick
Publikováno v:
The Journal of Organic Chemistry. 70:10488-10493
[reactions: see text] One-pot total syntheses of the quinazolinobenzodiazepine alkaloids sclerotigenin (1), (+/-)-circumdatin F (2), and (+/-)-asperlicin C (3) via novel microwave-assisted domino reactions were achieved in 55%, 32%, and 20% yields, r
Autor:
Jifeng Liu, Ping Ye, Daniel Yohannes, Libing Yu, Grace Bi, Katie Sargent, Bailin Zhang, Carmen M. Baldino
Publikováno v:
The Journal of Organic Chemistry. 70:6339-6345
A microwave-promoted three-component one-pot reaction has been developed to provide access to the core pyrazino[2,1-b]quinazoline-3,6-dione (1) scaffold, which is common to several families of alkaloids with significant biological activities. By adap
Publikováno v:
Tetrahedron Letters. 46:2911-2914
A straightforward and efficient method for the regioselective synthesis of functionalized 1,4-disubstituted [1,2,3]-triazoles, from terminal alkynes and azides, has been established utilizing Cu(0) as the source of the catalytic species. The presumed
Publikováno v:
Molecular Diversity. 9:81-89
A series of diverse indole-based chemotypes were synthesized from beta-tetrahydrocarboline (beta-THC) scaffolds prepared from commercially and readily available tryptamines and alpha-ketoesters. Diversity can be generated within these chemotypes thro
Publikováno v:
Synthesis. 2005:47-56
A highly efficient and versatile method for the synthesis of benzimidazoles was achieved in one step via the Na 2 S 2 O 4 reduction of o-nitroanilines in the presence of aldehydes. Heating a solution of o-nitroaniline (1c) and an aldehyde in EtOH or