Výsledky vyhledávání - "Carmen Lluis"

Akademický článek

Detection of Heteromers Formed by Cannabinoid CB1, Dopamine D2, and Adenosine A2A G-Protein-Coupled Receptors by Combining Bimolecular Fluorescence Complementation and Bioluminescence Energy Transfer

Autor: Gemma Navarro, Paulina Carriba, Jorge Gandí, Francisco Ciruela, Vicent Casadó, Antoni Cortés, Josefa Mallol, Enric I. Canela, Carmen Lluis, Rafael Franco

Publikováno v: The Scientific World Journal, Vol 8, Pp 1088-1097 (2008)

Functional interactions in signaling occur between dopamine D2 (D2R) and cannabinoid CB1 (CB1R) receptors, between CB1R and adenosine A2A (A2AR) receptors, and between D2R and A2AR. Furthermore, direct molecular interactions have been reported for th

Externí odkaz: https://doaj.org/article/9fe134e848d145319d1834a4feea5f3c

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Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington’s disease

Autor: Peter J. McCormick, Manuel Guzmán, Marco Scarselli, Anna Chiarlone, Carmen Lluis, Sergi Ferré, Antoni Cortés, Enric I. Canela, Joaquin Botta, David Moreno, Paola Gasperini, Silvia Ginés, Lesley A. Howell, Vicent Casadó, Jordi Alberch, Mar Puigdellívol, Mar Rodríguez-Ruiz, Estefanía Moreno

Publikováno v: eLife, Vol 9 (2020)
E-Prints Complutense. Archivo Institucional de la UCM
instname
Dipòsit Digital de la UB
Universidad de Barcelona
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid

Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D1R over-activation, we present a strategy based on targeting complexes of D1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23e7285a11572b27a47f14e0e42bdb6
https://eprints.ucm.es/62454/

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Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Addi. Archivo Digital para la Docencia y la Investigación
instname

The dorsal striatum is a key node for many neurobiological processes such as motor activity, cognitive functions, and affective processes. The proper functioning of striatal neurons relies critically on metabotropic receptors. Specifically, the main

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff55e963c5ffec8839b5fbf0e3518cc
http://hdl.handle.net/2445/172761

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Modulation of GABA Transport by Adenosine A1R–A2AR Heteromers, Which Are Coupled to Both Gs- and Gi/o-Proteins

Autor: Gemma Navarro, Carmen Lluis, Joaquim A. Ribeiro, Sandra H. Vaz, Fiorenzo Conti, Ana M. Sebastião, Sofia Cristóvão-Ferreira, Marc Brugarolas, Kamil Pérez-Capote, Rafael Franco, Vicent Casadó, Giorgia Fattorini, Peter J. McCormick

Publikováno v: The Journal of Neuroscience. 31:15629-15639

Astrocytes play a key role in modulating synaptic transmission by controlling the available extracellular GABA via the GAT-1 and GAT-3 GABA transporters (GATs). Using primary cultures of rat astrocytes, we show here that an additional level of regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e42f8618c7eda6695dd2c36148dced
https://doi.org/10.1523/jneurosci.2526-11.2011

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Real-Time G-Protein-Coupled Receptor Imaging to Understand and Quantify Receptor Dynamics

Autor: Carmen Lluis, Miguel Valencia, Jon López-Azcárate, Jordi Bonaventura, V. Casadó, Diana Fernández-Suárez, Gemma Navarro, Federico Mayor, Rafael Franco, María S. Aymerich, Julio Artieda

Publikováno v: The Scientific World Journal, Vol 11, Pp 1995-2010 (2011)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Dipòsit Digital de la UB
Universidad de Barcelona
The Scientific World Journal

Understanding the trafficking of G-protein-coupled receptors (GPCRs) and their regulation by agonists and antagonists is fundamental to develop more effective drugs. Optical methods using fluorescent-tagged receptors and spinning disk confocal micros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfe9004903c2e3e63f037a00ca438c7
https://doaj.org/article/72624f424c8a4b6b82bc061a2f856a4c

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Prime Time for G-Protein-Coupled Receptor Heteromers as Therapeutic Targets for CNS disorders: The Dopamine D1-D3 Receptor Heteromer

Autor: Carmen Lluis, Rafael Franco, Sergi Ferré, José L. Lanciego

Publikováno v: CNS & Neurological Disorders - Drug Targets. 9:596-600

A number of G-protein-coupled receptors (GPCRs) are currently under consideration as potential therapeutic targets for drugs acting in the central nervous system (CNS). Attempts to discover new medications have operated under the assumption that GPCR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6497217566e025247e0db563c134e0a
https://doi.org/10.2174/187152710793361603

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Direct involvement of σ-1 receptors in the dopamine D 1 receptor-mediated effects of cocaine

Autor: Rafael Franco, Enric I. Canela, Sergi Ferré, Kjell Fuxe, Gemma Navarro, Carmen Lluis, Josefa Mallol, Daniel Marcellino, Jordi Ortiz, Antoni Cortés, Vicent Casadó, Peter J. McCormick, M.S. Aymerich, Estefanía Moreno

Publikováno v: Proceedings of the National Academy of Sciences. 107:18676-18681

It is well known that cocaine blocks the dopamine transporter. This mechanism should lead to a general increase in dopaminergic neurotransmission, and yet dopamine D 1 receptors (D 1 Rs) play a more significant role in the behavioral effects of cocai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7809bf4cad324f3a4f47257ea30bb7
https://doi.org/10.1073/pnas.1008911107

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Human adenosine deaminase as an allosteric modulator of human A1adenosine receptor: abolishment of negative cooperativity for [3H](R)-pia binding to the caudate nucleus

Autor: Jesús A. García-Sevilla, J. Javier Meana, Josefa Mallol, Michael S. Herhsfield, Antoni Cortés, Enric I. Canela, Carmen Lluis, Eduard Gracia, Rafael Franco, Vicent Casadó

Publikováno v: Journal of Neurochemistry. 107:161-170

It has been shown that adenosine deaminase (ADA; EC 3.5.4.4) behaves as an ecto-enzyme anchored to membrane proteins, among them A1 adenosine receptors (A1Rs). Bovine ADA interacts with A1Rs from many species and regulates agonists binding to recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5542f139e0c045d76b0aa3dda2e83426
https://doi.org/10.1111/j.1471-4159.2008.05602.x

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Detection of heteromerization of more than two proteins by sequential BRET-FRET

Autor: Antoni Cortés, Sergi Ferré, Vicent Casadó, Josefa Mallol, Carmen Lluis, Gemma Navarro, Paulina Carriba, Kjell Fuxe, Luigi F. Agnati, Francisco Ciruela, Enric I. Canela, Rafael Franco

Publikováno v: Nature Methods. 5:727-733

Identification of higher-order oligomers in the plasma membrane is essential to decode the properties of molecular networks controlling intercellular communication. We combined bioluminescence resonance energy transfer (BRET) and fluorescence resonan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af8b2cced253a256229b5ecbc0c16ec
https://doi.org/10.1038/nmeth.1229

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