Výsledky vyhledávání - "Carmen Lagunas"

Akademický článek

Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.

Autor: Mar Orzáez, Mónica Sancho, Sandra Marchán, Laura Mondragón, Rebeca Montava, Juan García Valero, Olatz Landeta, Gorka Basañez, Rodrigo J Carbajo, Antonio Pineda-Lucena, Jordi Bujons, Alejandra Moure, Angel Messeguer, Carmen Lagunas, Carmen Herrero, Enrique Pérez-Payá

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e110979 (2014)

Excessive apoptosis induces unwanted cell death and promotes pathological conditions. Drug discovery efforts aimed at decreasing apoptotic damage initially targeted the inhibition of effector caspases. Although such inhibitors were effective, safety

Externí odkaz: https://doaj.org/article/3e08645d6c474a99896aed935439ac6b

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New insights into the mechanisms of action of topical administration of GLP-1 in an experimental model of diabetic retinopathy

Autor: Olga Simó-Servat, Marta Valeri, Carmen Lagunas, Mireia Turch, Patricia Bogdanov, Hugo Ramos, Cristina Solà-Adell, Rafael Simó, Cristina Hernández, Joel Sampedro

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Journal of Clinical Medicine
Volume 8
Issue 3
Journal of Clinical Medicine, Vol 8, Iss 3, p 339 (2019)

The main goals of this work were to assess whether the topical administration of glucagon-like peptide-1 (GLP-1) could revert the impairment of the neurovascular unit induced by long-term diabetes (24 weeks) in diabetic mice and to look into the unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ea545afcb38e222308b463930ada1c
https://ddd.uab.cat/record/216976

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IL-2 Induces Transient Arrest in the G1 Phase to Protect Cervical Cancer Cells from Entering Apoptosis

Autor: Leticia Rocha-Zavaleta, María del Carmen Lagunas-Cruz, Isabel Soto-Cruz, Benny Weiss-Steider, María de Lourdes Mora-García, Jonathan Trejo-Huerta, Arturo Valle-Mendiola, Adriana Gutiérrez-Hoya

Publikováno v: Journal of Oncology, Vol 2019 (2019)
Journal of Oncology

Interleukin 2 (IL-2) has been used for the treatment of different types of cancer that express the IL-2 receptor (IL-2R). However, the effect of IL-2 on cervical cancer cells is unknown. IL-2R is present in normal cells of the immune system but not i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c04afb9447ba8139ad58b685eb68efe
https://doaj.org/article/1302879d9cb44e48940eb20925184341

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Akademický článek

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Pleiotropic Effects of IL-2 on Cancer: Its Role in Cervical Cancer

Autor: Benny Weiss-Steider, Arturo Valle-Mendiola, Adriana Gutiérrez-Hoya, Isabel Soto-Cruz, María del Carmen Lagunas-Cruz

Publikováno v: Mediators of Inflammation
Mediators of Inflammation, Vol 2016 (2016)

IL-2 receptor (IL-2R) signalling is critical for normal lymphocyte proliferation, but its role in cervical cancer is not fully understood. The receptor is composed of three chains: IL-2α, IL-2β, and IL-2γ. Intracellular signalling is initiated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a12610649c79f2431e60486ee300cbc
https://pubmed.ncbi.nlm.nih.gov/27293315

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In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder

Autor: Dolors Balsa, M Ballarín, C. Salcedo, S Pérez-del-Pulgar, S Davalillo, J Cabellos, A.G. Fernández, Carmen Lagunas

Publikováno v: British Journal of Pharmacology. 156:807-817

Background and purpose: Highly selective M3 muscarinic receptor antagonists may represent a better treatment for overactive bladder syndrome, diminishing side effects. Cardiac side effects of non-selective antimuscarinics have been associated with ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bfa1e0c6a0d1ccd0019122fd08529ec
https://doi.org/10.1111/j.1476-5381.2008.00082.x

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Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity

Autor: Sandra Marchán, Gorka Basañez, Rodrigo J. Carbajo, Jordi Bujons, Angel Messeguer, Laura Mondragón, Olatz Landeta, Mar Orzáez, Enrique Pérez-Payá, Antonio Pineda-Lucena, Rebeca Montava, Juan G. Valero, Mónica Sancho, Alejandra Moure, Carmen Lagunas, Carmen Herrero

Publikováno v: Plos One
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
Digital.CSIC. Repositorio Institucional del CSIC
Addi. Archivo Digital para la Docencia y la Investigación
PLoS ONE, Vol 9, Iss 10, p e110979 (2014)
PLoS ONE
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

11 páginas, 4 figuras.
BACKGROUND: Excessive apoptosis induces unwanted cell death and promotes pathological conditions. Drug discovery efforts aimed at decreasing apoptotic damage initially targeted the inhibition of effector caspases. Althoug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540b28fdd9b9bb28d9e5c84231014563
http://hdl.handle.net/10261/103949

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Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors

Autor: Tomas Roca, Juan-Lorenzo Catena, Joan Bosch, Ignasi Miquel, Oriol Llorens, Ana Fernandez‐Serrat, Juan‐Jesus Perez, A.G. Fernández, Carmen Lagunas, Carles Farrerons

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:1745-1748

The synthesis and structure–activity relationships (SAR) of a series of novel selective COX-2 inhibitors are reported. The results show that some of the 1,3,4-triaryl-3-pyrrolin-2-ones 1 are more potent as COX-2 inhibitors than celecoxib, and that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d459ee1b476aef94de369040117f46a2
https://doi.org/10.1016/s0960-894x(00)00329-2

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Akademický článek

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Effects of linoleic and oleic acid anilides on prostacyclin synthesis and fibrinolytic profile of human endothelial cells in culture: relevance to the toxic oil syndrome

Autor: Jordi Fontcuberta, Carmen Lagunas, Luis M. Vilá, Isabel Pich, Carlos Chanquia, Miquel Rutllant, Conxita de Castellarnau

Publikováno v: Toxicology. 81:181-194

We evaluated the effects of fatty-acid anilides (FAA) on prostacyclin (PGI 2 ) synthesis and on the fibrinolytic properties of human umbilical vein endothelial cells. Preincubation of endothelial cells with oleic- and linoleic-anilides (OAA and LAA,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af135364965419eef800b2da112449a
https://doi.org/10.1016/0300-483x(93)90011-g

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