Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Carmen Laethem"'
1
Secretion of Proinflammatory Cytokines and Chemokines during Amphotericin B Exposure Is Mediated by Coactivation of Toll-Like Receptors 1 and 2
Autor: Harold L. Watson, Paul A. Johnston, Martin Henault, Carmen Laethem, Linda N. Lee, Raymund R. Razonable, Carlos V. Paya
Publikováno v: Antimicrobial Agents and Chemotherapy. 49:1617-1621
Amphotericin B (AmB) is a ligand of toll-like receptor 2 (TLR2). Here, we demonstrate the participation of TLR1 in AmB-induced cell activation that led to the secretion of tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-8. Hence, TLR2-TLR1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80e7c0f192ba50c54147b9265866354
https://doi.org/10.1128/aac.49.4.1617-1621.2005
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2
Development and implementation of three mitogen-activated protein kinase (MAPK) signaling pathway imaging assays to provide MAPK module selectivity profiling for kinase inhibitors: MK2-EGFP translocation, c-Jun, and ERK activation
Autor: Debra, Nickischer, Carmen, Laethem, Oscar J, Trask, Rhonda Gates, Williams, Ramani, Kandasamy, Patricia A, Johnston, Paul A, Johnston
Publikováno v: Methods in enzymology. 414
This chapter describes the development and implementation of three independent imaging assays for the major mitogen-activated protein kinase (MAPK) signaling modules: p38, JNK, and ERK. There are more than 500 protein kinases encoded in the human gen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b508907b0ee872819b64bcfbdd235be3
https://pubmed.ncbi.nlm.nih.gov/17110204
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3
Generation and characterization of a stable MK2-EGFP cell line and subsequent development of a high-content imaging assay on the Cellomics ArrayScan platform to screen for p38 mitogen-activated protein kinase inhibitors
Autor: Rhonda Gates, Williams, Ramani, Kandasamy, Debra, Nickischer, Oscar J, Trask, Carmen, Laethem, Patricia A, Johnston, Paul A, Johnston
Publikováno v: Methods in enzymology. 414
This chapter describes the generation and characterization of a stable MK2-EGFP expressing HeLa cell line and the subsequent development of a high-content imaging assay on the Cellomics ArrayScan platform to screen for p38 MAPK inhibitors. Mitogen-ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a78a9d0062d0dd427a046b32cfa902b
https://pubmed.ncbi.nlm.nih.gov/17110203
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4
Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform
Autor: Oscar J, Trask, Audrey, Baker, Rhonda Gates, Williams, Debra, Nickischer, Ramani, Kandasamy, Carmen, Laethem, Patricia A, Johnston, Paul A, Johnston
Publikováno v: Methods in enzymology. 414
This chapter describes the conversion and assay development of a 96-well MK2-EGFP translocation assay into a higher density 384-well format high-content assay to be screened on the ArrayScan 3.1 imaging platform. The assay takes advantage of the well
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4aed3d61208c2f3622c5e96ffa1d478a
https://pubmed.ncbi.nlm.nih.gov/17110205
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