Stereocontrol in the Synthesis of β-Lactams Arising from the Interlocked Structure of Benzylfumaramide-Based Hydrogen-Bonded [2]Rotaxanes

Autor: Mateo Alajarin, Alberto Martinez-Cuezva, Carmen López-Leonardo, Jose Berna

Publikováno v: DIGITUM: Depósito Digital Institucional de la Universidad de Murcia
Universidad de Murcia
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname

β-Lactams are highly valuable compounds due to their antibiotic activity. Among the number of well-established methodologies for building this privileged scaffold, our research group has settled on a novel synthetic approach for their preparation. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79f164cd48225f61d781081f86100c4
https://doi.org/10.1055/s-0037-1611705

Reduced nicotinamide mononucleotide is a new and potent nad+ precursor in mammalian cells and mice

Autor: Hyung L. Elfrink, Alessandra Tammaro, Riekelt H. Houtkooper, Álvaro Sánchez-Ferrer, Michel van Weeghel, Carles Cantó, Bauke V. Schomakers, Rubén Zapata-Pérez, Rebecca L. McIntyre, Simone Denis, Judith Giroud-Gerbetant, Carmen López-Leonardo, Angelique M. L. Scantlebery

Publikováno v: FASEB journal, 35(4):e21456, 1-17. FASEB
The FASEB Journal

Nicotinamide adenine dinucleotide (NAD+ ) homeostasis is constantly compromised due to degradation by NAD+ -dependent enzymes. NAD+ replenishment by supplementation with the NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30fbf40d99114633c328f5f648260d8
https://pure.amc.nl/en/publications/reduced-nicotinamide-mononucleotide-is-a-new-and-potent-nad-precursor-in-mammalian-cells-and-mice(759059d7-2e8e-46df-bc33-73000ed0679b).html

Exploring the Conversion of Macrocyclic 2,2'-Biaryl Bis(thioureas) into Cyclic Monothioureas: An Experimental and Computational Investigation

Autor: Raul-Angel Orenes, Aurelia Pastor, Pilar Sanchez-Andrada, Carmen López-Leonardo, Angel Vidal, Mateo Alajarin

Publikováno v: DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname
DIGITUM: Depósito Digital Institucional de la Universidad de Murcia
Universidad de Murcia

Macrocyclic bis(thioureas) derived from 2,2′-biphenyl and binaphthyl skeletons have been synthesized by reaction of 2,2′-diaminobiaryl and 2,2′-bis(isothiocyanato)biaryl derivatives. The splitting of these bis(thioureas) into two units of the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12829cfc62a4b2b6c128e8d6da1edc4b
https://pubmed.ncbi.nlm.nih.gov/30352148

Stereocontrolled Synthesis of β-Lactams within [2]Rotaxanes: Showcasing the Chemical Consequences of the Mechanical Bond

Autor: Jose Berna, Alberto Martinez-Cuezva, Carmen López-Leonardo, Delia Bautista, Mateo Alajarin

Publikováno v: DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname

The intramolecular cyclization of N-benzyl fumaramide [2]rotaxanes is described. The mechanical bond of these substrates activates this transformation to proceed in high yields and in a regio- and diastereoselective manner giving interlocked 3,4-disu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bc5d41cac972ca36f57b0b79b9673d
https://pubmed.ncbi.nlm.nih.gov/27355271

Regiodivergent Approach to α- and β-(Arylthio)alkenylphosphane Oxides and Sulfides: Aminophosphanes as Synthetic Auxiliaries

Autor: Mateo Alajarin, Rosalia Raja, Carmen López-Leonardo

Publikováno v: Synlett. 2008:3172-3176

β-(Arylthio)ethenylphosphane oxides and sulfides are easilyprepared by nucleophilic addition of thiophenols to the C°C bondof the respective P, P-diphenyl- P-phenylethynyl P(V) derivatives. Theregioisomeric α-(arylthio) analogues can be also prepa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b99470f81f2d876c809b4d438ae64e6e
https://doi.org/10.1055/s-0028-1087416