New insights into vitamin K biology with relevance to cancer

Autor: JoEllen, Welsh, Min Ji, Bak, Carmen J, Narvaez

Publikováno v: Trends in Molecular Medicine. 28:864-881

Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) are essential for post-translational γ-carboxylation of a small number of proteins, including clotting factors. These modified proteins have now been implicated in diverse physiological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5edc4ef5596f962025c52dd3c890557
https://doi.org/10.1016/j.molmed.2022.07.002

Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast cancer

Autor: Samantha Robilotto, Erika LaPorta, JoEllen Welsh, Carmen J. Narvaez, Jennifer Liang

Publikováno v: Oncotarget

1,25-Dihydroxyvitamin D3 (1,25D3) induces growth arrest and apoptosis in breast cancer cells in vivo and in vitro, however the exact mechanisms are unclear. Although the vitamin D receptor (VDR), a ligand dependent transcription factor, is required f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c9fb8073ad12f96375327612260810
http://europepmc.org/articles/PMC7392624

Vitamin D regulation of HAS2, hyaluronan synthesis and metabolism in triple negative breast cancer cells

Autor: Carmen J. Narvaez, S. Balinth, JoEllen Welsh, D. Grebenc

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 201:105688

The vitamin D receptor (VDR) and its ligand 1,25(OH)2D3 (1,25D) exert anti-tumor effects, but considerable heterogeneity has been reported in different model systems. In general, cell lines derived from aggressive tumor subtypes such as Triple Negati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd9fe9135170bdbb6f7a7799a16fb2b
https://doi.org/10.1016/j.jsbmb.2020.105688

List of Contributors

Autor: John S. Adams, Judith E. Adams, Jawaher A. Alsalem, Paul H. Anderson, Panagiota Andreopoulou, Edith Angellotti, Leggy A. Arnold, Gerald J. Atkins, Antonio Barbáchano, Shari S. Bassuk, Sarah Beaudin, Anna Y. Belorusova, Nancy A. Benkusky, Carlos Bernal-Mizrachi, Ishir Bhan, Harjit P. Bhattoa, Daniel D. Bikle, John P. Bilezikian, Neil C. Binkley, Heike A. Bischoff-Ferrari, Charles W. Bishop, Ida M. Boisen, Fabrizio Bonelli, Adele L. Boskey, Barbara J. Boucher, Roger Bouillon, Manuella Bouttier, Barbara D. Boyan, Danny Bruce, Laura Buburuzan, Andrew J. Burghardt, Thomas H.J. Burne, Mona S. Calvo, Carlos A. Camargo, Jorge B. Cannata-Andia, Margherita T. Cantorna, Carsten Carlberg, Geert Carmeliet, Thomas O. Carpenter, Graham D. Carter, Kevin D. Cashman, Lisa Ceglia, Sylvia Christakos, Kenneth B. Christopher, Rene F. Chun, Fredric L. Coe, Frederick Coffman, Juliet Compston, Cyrus Cooper, Elizabeth M. Curtis, Natalie E. Cusano, Michael Danilenko, G. David Roodman, Bess Dawson-Hughes, Pierre De Clercq, Hector F. DeLuca, Julie Demaret, Marie B. Demay, David W. Dempster, Elaine M. Dennison, Puneet Dhawan, Vassil Dimitrov, Katie M. Dixon, Maryam Doroudi, Shevaun M. Doyle, Adriana S. Dusso, Aleksey Dvorzhinskiy, Peter R. Ebeling, John A. Eisman, Gregory R. Emkey, Ervin H. Epstein Jr., Sol Epstein, Darryl Eyles, Murray J. Favus, David Feldman, Gemma Ferrer-Mayorga, David M. Findlay, James C. Fleet, Brian L. Foster, Renny T. Franceschi, David R. Fraser, Jessica M. Furst, Rachel I. Gafni, Edward Giovannucci, Christian M. Girgis, James L. Gleason, Francis H. Glorieux, Elzbieta Gocek, David Goltzman, José Manuel González-Sancho, Laura A. Graeff-Armas, William B. Grant, Natalie J. Groves, Conny Gysemans, Lasse Bøllehuus Hansen, Nicholas C. Harvey, Catherine M. Hawrylowicz, Colleen E. Hayes, Robert P. Heaney, Geoffrey N. Hendy, Pamela A. Hershberger, Martin Hewison, Michael F. Holick, Bruce W. Hollis, Philippe P. Hujoel, Elina Hyppönen, Karl L. Insogna, Nina G. Jablonski, Martin Blomberg Jensen, David A. Jolliffe, Glenville Jones, Kerry S. Jones, Harald Jüppner, Enikö Kallay, Andrew C. Karaplis, Martin Kaufmann, Mairead Kiely, Tiffany Y, Kim, Martin Konrad, Christopher S. Kovacs, Richard Kremer, Roland Krug, Rajiv Kumar, Noriyoshi Kurihara, Emma Laing, Joseph M. Lane, Dean P. Larner, María Jesús Larriba, Gilles Laverny, Nathalie Le Roy, Seong M. Lee, Michael A. Levine, Richard Lewis, Paul Lips, Thomas S. Lisse, Eva S. Liu, Philip T. Liu, Yan Li, Yan Chun Li, James G. MacKrell, Leila J. Mady, Sharmila Majumdar, Makoto Makishima, Peter J. Malloy, Elizabeth H. Mann, JoAnn E. Manson, Adrian R. Martineau, Rebecca S. Mason, Chantal Mathieu, Toshio Matsumoto, Donald G. Matthews, John J. McGrath, Daniel Metzger, Mark B. Meyer, Denshun Miao, Mathew T. Mizwicki, Rebecca J. Moon, Howard A. Morris, Li J. Mortensen, Alberto Muñoz, Yuko Nakamichi, Carmen J. Narvaez, Faye E. Nashold, Tally Naveh-Many, Carrie M. Nielson, Anthony W. Norman, Yves Nys, Melda Onal, Lubna Pal, Kristine Y. Patterson, Steven Pauwels, Pamela R. Pehrsson, Martin Petkovich, John M. Pettifor, Paul E. Pfeffer, Katherine M. Phillips, J. Wesley Pike, Stefan Pilz, Anastassios G. Pittas, Pawel Pludowski, David E. Prosser, Sri Ramulu N. Pullagura, L. Darryl Quarles, Rithwick Rajagopal, Katherine J. Ransohoff, Saaeha Rauz, Brian J. Rebolledo, Jörg Reichrath, Sandra Rieger, Amy E. Riek, Natacha Rochel, Jeffrey D. Roizen, Janet M. Roseland, Cliff Rosen, Mark S. Rybchyn, Hiroshi Saitoh, Reyhaneh Salehi-Tabar, Anne L. Schafer, Karl P. Schlingmann, Inez Schoenmakers, Zvi Schwartz, Kayla Scott, Christopher T. Sempos, Lusia Sepiashvili, Mukund Seshadri, Elizabeth Shane, Tatiana Shaurova, Irene Shui, Justin Silver, Ravinder J. Singh, Linda Skingle, René St-Arnaud, Jessica Starr, Keith R. Stayrook, Emily M. Stein, Ryan E. Stites, George P. Studzinski, Tatsuo Suda, Fumiaki Takahashi, Naoyuki Takahashi, Jean Y. Tang, Christine L. Taylor, Hugh S. Taylor, Peter J. Tebben, Thomas D. Thacher, Ravi Thadhani, Kebashni Thandrayen, Susan Thys-Jacobs, Dov Tiosano, Roberto Toni, Dwight A. Towler, Donald L. Trump, Nobuyuki Udagawa, André G. Uitterlinden, Aasis Unnanuntana, Jeroen van de Peppel, Bram C.J. van der Eerden, Marjolein van Driel, Johannes P.T.M. van Leeuwen, Natasja van Schoor, An-Sofie Vanherwegen, Aria Vazirnia, Lieve Verlinden, Annemieke Verstuyf, Reinhold Vieth, Carol L. Wagner, Graham R. Wallace, Connie Weaver, JoEllen Welsh, John H. White, Susan J. Whiting, Michael P. Whyte, John J. Wysolmerski, Sachiko Yamada, Olivia B. Yu, Kathryn Zavala, Christoph Zechner, Meltem Zeytinoglu, Hengguang Zhao

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ed16d9caf029689592e5e6285e6050c
https://doi.org/10.1016/b978-0-12-809965-0.01002-8

Gene Signatures of 1,25-Dihydroxyvitamin D3Exposure in Normal and Transformed Mammary Cells

Autor: Sarah Beaudin, Carmen J. Narvaez, Katrina Simmons, JoEllen Welsh

Publikováno v: Journal of Cellular Biochemistry. 116:1693-1711

To elucidate potential mediators of vitamin D receptor (VDR) action in breast cancer, we profiled the genomic effects of its ligand 1,25-dihydroxyvitamin D3 (1,25D) in cells derived from normal mammary tissue and breast cancer. In non-transformed hTE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fde44a31c9f7b000df7a15fc85ac63e
https://doi.org/10.1002/jcb.25129