Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns

Autor: Saioa Márquez, José Javier Fernández, Cristina Mancebo, Carmen Herrero-Sánchez, Sara Alonso, Tito A. Sandoval, Macarena Rodríguez Prados, Juan R. Cubillos-Ruiz, Olimpio Montero, Nieves Fernández, Mariano Sánchez Crespo

Publikováno v: Cell Reports, Vol 27, Iss 2, Pp 525-536.e4 (2019)

Summary: Increased glycolysis parallels immune cell activation, but the role of pyruvate remains largely unexplored. We found that stimulation of dendritic cells with the fungal surrogate zymosan causes decreases of pyruvate, citrate, itaconate, and

Externí odkaz: https://doaj.org/article/d3479312dcbe454eb89d563a51052af9

Tricarboxylic acid cycle activity and remodeling of glycerophosphocholine lipids support cytokine induction in response to fungal patterns

Autor: Cristina Mancebo, Tito A. Sandoval, Olimpio Montero, Mariano Sánchez Crespo, Sara Alonso, Saioa Márquez, Macarena Rodríguez Prados, Carmen Herrero-Sánchez, Juan R. Cubillos-Ruiz, Nieves Fernández, José Javier Fernández

Publikováno v: UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname
Cell Reports, Vol 27, Iss 2, Pp 525-536.e4 (2019)
Digital.CSIC. Repositorio Institucional del CSIC

Producción Científica
Increased glycolysis parallels immune cell activation, but the role of pyruvate remains largely unexplored. We found that stimulation of dendritic cells with the fungal surrogate zymosan causes decreases of pyruvate, citr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf5c74288568783051ae1f26e14c228
https://uvadoc.uva.es/handle/10324/55101

Immunomodulatory effects of bone marrow versus adipose tissue-derived mesenchymal stromal cells on NK cells: implications in the transplantation setting

Autor: Fermín Sánchez-Guijo, Juan F. Blanco, María Lourdes García‐Martínez, Mariano García-Arranz, Belén Blanco, Sandra Muntión, María del Carmen Herrero‐Sánchez, Concepción Rodríguez-Serrano, Consuelo del Cañizo

Publikováno v: European Journal of Haematology. 97:528-537

Introduction The ability of mesenchymal stromal cells (MSC) to suppress T-cell function has prompted their therapeutic use for graft-versus-host disease (GVHD) control. However, as MSC also modulate the activity of NK cells, which play an important r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60037d1bba3f3e057126c62197f33f67
https://doi.org/10.1111/ejh.12765

Tricarboxylic Acid Cycle Activity and Glycerophosphocholine Lipid Recycling Support Dendritic Cell Cytokine Induction in Response to Fungal Patterns

Autor: Cristina Mancebo, Tito A. Sandoval, Mariano Sánchez Crespo, Carmen Herrero-Sánchez, Olimpio Montero, José Javier Fernández, Saioa Márquez, Macarena Rodríguez Prados, Nieves Fernández, Sara Alonso, Juan R. Cubillos-Ruiz

Publikováno v: SSRN Electronic Journal.

Increased glycolysis parallels immune cell activation, but the role of pyruvate flux remains largely unexplored. We show that stimulation of dendritic cells with the fungal surrogate zymosan induces a drop of pyruvate, citrate, itaconate, and α-keto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91d3972f449cdc55071e060233eb6c0a
https://doi.org/10.2139/ssrn.3275283

Effect of mTORC1/mTORC2 inhibition on T cell function: potential role in graft-versus-host disease control

Autor: Jesús García-Briñón, Jesús F. San-Miguel, Belén Blanco, Julia Almeida, Mª Carmen Herrero-Sánchez, Consuelo del Cañizo, Concepción Rodríguez-Serrano, Ángel Santos-Briz, Susana Inogés, Laura San-Segundo

Publikováno v: UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname

Producción Científica
The mechanistic target of rapamycin (mTOR) pathway is crucial for the activation and function of T cells, which play an essential role in the development of graft-versus-host disease (GvHD). Despite its partial ability to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448588c54ecdb813916f193d823c6e80
https://doi.org/10.1111/bjh.13984