Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Carmen Grijota-Martínez"'
Autor:
Eva Rial-Pensado, Verónica Rivas-Limeres, Carmen Grijota-Martínez, Amanda Rodríguez-Díaz, Valentina Capelli, Olga Barca-Mayo, Rubén Nogueiras, Jens Mittag, Carlos Diéguez, Miguel López
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in hyperthyroid patients. However, the current landscape of preclinical thyroid hormone models is c
Externí odkaz:
https://doaj.org/article/ea30a9aedfd444fdb8d55a60b3240128
Autor:
Víctor Valcárcel-Hernández, Marina Guillén-Yunta, Miranda Bueno-Arribas, Ana Montero-Pedrazuela, Carmen Grijota-Martínez, Suzy Markossian, Ángel García-Aldea, Frédéric Flamant, Soledad Bárez-López, Ana Guadaño-Ferraz
Publikováno v:
Neurobiology of Disease, Vol 174, Iss , Pp 105896- (2022)
Inactivating mutations in the specific thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to an X-linked rare disease named MCT8 deficiency or Allan-Herndon-Dudley Syndrome. Patients exhibit a plethora of severe endocrine and neuro
Externí odkaz:
https://doaj.org/article/272bf65832e14e22823ca721de1521f1
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Allan-Herndon-Dudley syndrome is a rare disease caused by inactivating mutations in the SLC16A2 gene, which encodes the monocarboxylate transporter 8 (MCT8), a transmembrane transporter specific for thyroid hormones (T3 and T4). Lack of MCT8 function
Externí odkaz:
https://doaj.org/article/b7a45ec4ce1946a29d7ce981df4cde9c
Autor:
Carmen Grijota-Martínez, Soledad Bárez-López, Eva Ausó, Samuel Refetoff, William H Frey, Ana Guadaño-Ferraz
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236113 (2020)
Loss of function mutations in the gene encoding the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to severe neurodevelopmental defects in humans associated with a specific thyroid hormone phenotype manifesting high serum 3,5,3
Externí odkaz:
https://doaj.org/article/e924283ba5ba445dab11b8d6c0fc93ff
Autor:
Valentina Capelli, Carmen Grijota-Martínez, Nathalia R. V. Dragano, Eval Rial-Pensado, Johan Fernø, Rubén Nogueiras, Jens Mittag, Carlos Diéguez, Miguel López
Publikováno v:
Nutrients, Vol 13, Iss 12, p 4204 (2021)
Besides their direct effects on peripheral metabolic tissues, thyroid hormones (TH) act on the hypothalamus to modulate energy homeostasis. However, since most of the hypothalamic actions of TH have been addressed in studies with direct central admin
Externí odkaz:
https://doaj.org/article/ebc1e718f1224c7393b42b40cf6fe603
Autor:
Soledad Bárez-López, Carmen Grijota-Martínez, Xiao-Hui Liao, Samuel Refetoff, Ana Guadaño-Ferraz
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226017 (2019)
Patients lacking the thyroid hormone (TH) transporter MCT8 present abnormal serum levels of TH: low thyroxine and high triiodothyronine. They also have severe neurodevelopmental defects resulting from cerebral hypothyroidism, most likely due to impai
Externí odkaz:
https://doaj.org/article/c5e1e5e47e3d4dccadf221020cea86cf
Autor:
Tiago B Rodrigues, Ainhoa Ceballos, Carmen Grijota-Martínez, Barbara Nuñez, Samuel Refetoff, Sebastian Cerdán, Beatriz Morte, Juan Bernal
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e74621 (2013)
Mutations of the monocarboxylate transporter 8 (MCT8) cause a severe X-linked intellectual deficit and neurological impairment. MCT8 is a specific thyroid hormone (T4 and T3) transporter and the patients also present unusual abnormalities in the seru
Externí odkaz:
https://doaj.org/article/731bcf4cf7ca4c42ab7b10cb91daafb6
Autor:
Carmen Grijota-Martínez, Ana Montero-Pedrazuela, Jorge Hidalgo-Álvarez, Soledad Bárez-López, Ana Guadaño-Ferraz
Publikováno v:
Thyroid. 33:501-510
Autor:
Carmen, Grijota-Martínez, Ana, Montero-Pedrazuela, Jorge, Hidalgo-Álvarez, Soledad, Bárez-López, Ana, Guadaño-Ferraz
Publikováno v:
Thyroid : official journal of the American Thyroid Association.
Patients lacking functional Monocarboxylate transporter 8 (MCT8), a highly specific thyroid hormone (TH) transporter, present severe psychomotor disabilities. MCT8 deficiency leads to peripheral hyperthyroidism and brain hypothyroidism, the latter du
Autor:
Gema Esquiva Sobrino, Maria Del Carmen Grijota Martínez, Ana Cifuentes Martínez, Violeta Gómez Vicente, V. García Sousa, J.V. García Velasco, Eva Ausó Monreal
Publikováno v:
EDULEARN Proceedings.