Structuring detergents for extracting and stabilizing functional membrane proteins.

Autor: Rima Matar-Merheb, Moez Rhimi, Antoine Leydier, Frédéric Huché, Carmen Galián, Elodie Desuzinges-Mandon, Damien Ficheux, David Flot, Nushin Aghajari, Richard Kahn, Attilio Di Pietro, Jean-Michel Jault, Anthony W Coleman, Pierre Falson

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e18036 (2011)

BACKGROUND: Membrane proteins are privileged pharmaceutical targets for which the development of structure-based drug design is challenging. One underlying reason is the fact that detergents do not stabilize membrane domains as efficiently as natural

Externí odkaz: https://doaj.org/article/d1116ef3cda343c380bc293ef9c8badf

Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development and in adult rat tissues

Autor: Juan Ramón Martínez-Morales, Paola Bovolenta, Araceli del Arco, Carmen Galián, Jorgina Satrústegui, Julian Morcillo, Vera Martos

Publikováno v: European Journal of Biochemistry. 269:3313-3320

Aralar1 and citrin are members of the subfamily of calciumbinding mitochondrial carriers and correspond to two isoforms of the mitochondrial aspartate/glutamate carrier (AGC). These proteins are activated by Ca 2+ acting on the external side of the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0f23766d5ee08130d5400f358aaed88
https://doi.org/10.1046/j.1432-1033.2002.03018.x

Structuring detergents for extracting and stabilizing functional membrane proteins

Autor: Carmen Galián, Damien Ficheux, Antoine Leydier, Pierre Falson, Jean-Michel Jault, David Flot, Moez Rhimi, Frédéric Huché, Nushin Aghajari, Attilio Di Pietro, Rima Matar-Merheb, Richard Kahn, Anthony W. Coleman, Elodie Desuzinges-Mandon

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2011, 6 (3), pp.e18036. ⟨10.1371/journal.pone.0018036⟩
Plos One 3 (6), e18036. (2011)
PLoS ONE, Vol 6, Iss 3, p e18036 (2011)
PLoS ONE, 2011, 6 (3), pp.e18036. ⟨10.1371/journal.pone.0018036⟩

International audience; Background: Membrane proteins are privileged pharmaceutical targets for which the development of structure-based drug design is challenging. One underlying reason is the fact that detergents do not stabilize membrane domains a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b362d5948a32dc6edba26023a5f6de7a
https://hal.inrae.fr/hal-02650286/document

The YheI/YheH heterodimer from Bacillus subtilis is a multidrug ABC transporter

Autor: Carmen Galián, Jean-Raphaël Fantino, Cristina Torres, Christoph Freiberg, Jean-Michel Jault

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. (3):615-622

ABC (ATP-binding cassette) transporters form the largest family of membrane proteins in micro-organisms where they are able to transport a wide variety of substrates against a concentration gradient, in an ATP-dependent process. Two genes from the sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c810d85a7c9926c3ea9b543577225bdc