Identification and expression of the 11β‐steroid hydroxylase from Cochliobolus lunatus in Corynebacterium glutamicum

Autor: Carmen Felpeto‐Santero, Beatriz Galán, José M. Luengo, José M. Fernández‐Cañon, Carlos delCerro, Francisco J. Medrano, José L. García

Publikováno v: Microbial Biotechnology, Vol 12, Iss 5, Pp 856-868 (2019)

Summary Hydroxylation of steroids has acquired special relevance for the pharmaceutical industries. Particularly, the 11β‐hydroxylation of steroids is a reaction of biotechnological importance currently carried out at industrial scale by the fungu

Externí odkaz: https://doaj.org/article/92166c0ca59348a9be270f1ceeadee13

Production of 11α‐hydroxysteroids from sterols in a single fermentation step by Mycolicibacterium smegmatis

Autor: Beatriz Galán, Carmen Felpeto-Santero, José Luis García

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Microbial Biotechnology
Microbial Biotechnology, Vol 14, Iss 6, Pp 2514-2524 (2021)

11 p.-2 fig.-3 tab.
11α‐hydroxylated steroid synthons are one of the most important commercially pharmaceutical intermediates used for the production of contraceptive drugs and glucocorticoids. These compounds are currently produced by biotra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab854ffce73b7559583f16d37e9ead9a
https://doi.org/10.1111/1751-7915.13735

Engineering the Steroid Hydroxylating System from Cochliobolus lunatus in Mycolicibacterium smegmatis

Autor: Beatriz Galán, Carmen Felpeto-Santero, José Luis García

Publikováno v: Microorganisms
Volume 9
Issue 7
Microorganisms, Vol 9, Iss 1499, p 1499 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname

13 p.-5 fig.-1 tab.
14α-hydroxylated steroids are starting materials for the synthesis of contraceptive and anti-inflammatory compounds in the steroid industry. A synthetic bacterial operon containing the cytochrome P450 CYP103168 and the reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376f93d2d61e0bb8eb92e29fad7848be
https://doi.org/10.3390/microorganisms9071499

Production of 4-Ene-3-ketosteroids in Corynebacterium glutamicum

Autor: José Luis García, Carmen Felpeto-Santero, Beatriz Galán, José Luis Barredo, Julia García-Fernández

Publikováno v: Catalysts, Vol 7, Iss 11, p 316 (2017)
Catalysts; Volume 7; Issue 11; Pages: 316

Corynebacterium glutamicum has been widely used for the industrial production of amino acids and many value-added chemicals; however, it has not been exploited for the production of steroids. Using C. glutamicum as a cellular biocatalyst we have expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07f1520f50f35dffc957e052810a148
https://www.mdpi.com/2073-4344/7/11/316

Bioconversion of Phytosterols into Androstadienedione by Mycobacterium smegmatis CECT 8331

Autor: Beatriz Galán, Julia García-Fernández, Lorena Fernández-Cabezón, J. Garcia, Igor Martínez, Carmen Felpeto-Santero

Publikováno v: Microbial Steroids ISBN: 9781493971824

The C19 steroid 1,4-androstadiene-3,17-dione (androstadienedione, ADD) is an added value product used as a synthon in the pharmaceutical industry for the commercial production of corticosteroids, mineralocorticoids, oral contraceptives, and other pha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4a980d98ee9dca59bcd47af474ffb32
https://doi.org/10.1007/978-1-4939-7183-1_15