Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Carmen Doebele"'
Autor:
Pan Fang, Yanlong Ji, Ivan Silbern, Carmen Doebele, Momchil Ninov, Christof Lenz, Thomas Oellerich, Kuan-Ting Pan, Henning Urlaub
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Comprehensive quantitative profiling of intact glycopeptides remains technically challenging. To address this, the authors here develop an integrated quantitative glycoproteomic workflow, including optimized sample preparation, multiplexed quantifica
Externí odkaz:
https://doaj.org/article/b98847062cd64d348c1ad9038cab217f
Autor:
Sebastian Wolf, Constanze Schneider, Roland Schmitz, Kwang Seok Lee, Mikolaj Slabicki, Hans Christian Reinhardt, Henning Urlaub, Craig J. Thomas, Anne C. Wilke, Hubert Serve, Fernando Kreuz, Joshua D. Rabinowitz, Dominique Jahn, Michele Ceribelli, Christian Brandts, Kimberly Stegmaier, Matthew G. Vander Heiden, Caroline A. Lewis, Thomas Oellerich, Kamil Bojarczuk, Thorsten Zenz, Daniel J. Hodson, Sara A Rieke, Yana Pikman, James Q Wang, Xincheng Xu, Michael Engelke, Hahn Kim, Hanibal Bohnenberger, Zana A. Coulibaly, Clemens A Schmitt, Federico Comoglio, James D. Phelan, Louis M. Staudt, Carmen Doebele, Sebastian Scheich, Björn Chapuy, Frank Schnuetgen, Gero Knittel, Frances A. Tosto, Philipp Stroebel, Alena Zindel, Björn Häupl, Philipp Stauder, Thanh Hung Dang
Publikováno v:
Blood
Burkitt lymphoma (BL) is an aggressive lymphoma type that is currently treated by intensive chemoimmunotherapy. Despite the favorable clinical outcome for most patients with BL, chemotherapy-related toxicity and disease relapse remain major clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c349f4bea2879f17146194265cc0ec5e
https://doi.org/10.1182/blood.2021012081
https://doi.org/10.1182/blood.2021012081
Autor:
Louis M. Staudt, Carmen Doebele, Hang Nguyen, Arthur L. Shaffer, Angelika Oellerich, Yanlong Ji, Thomas Oellerich, George E. Wright, Samantha Schaller, Sebastian Scheich, Richard Longnecker, Jagan R. Muppidi, Kuan-Ting Pan, Henning Urlaub, Kamonwan Fish, Hubert Serve, Federico Comoglio, Masato Ikeda
Publikováno v:
Proc Natl Acad Sci U S A
Epstein-Barr virus (EBV) infects human B cells and reprograms them to allow virus replication and persistence. One key viral factor in this process is latent membrane protein 2A (LMP2A), which has been described as a B cell receptor (BCR) mimic promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf1bf5c332e99ab65fc5b621d6e908d
https://doi.org/10.1073/pnas.2007946117
https://doi.org/10.1073/pnas.2007946117
Autor:
Yanlong Ji, Kuan-Ting Pan, Thomas Oellerich, Ivan Silbern, Pan Fang, Henning Urlaub, Momchil Ninov, Carmen Doebele, Christof Lenz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Regulation of protein N-glycosylation is essential in human cells. However, large-scale, accurate, and site-specific quantification of glycosylation is still technically challenging. We here introduce SugarQuant, an integrated mass spectrometry-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3038938fe6fe2ad19096b03b3ab5350e
http://link.springer.com/article/10.1038/s41467-020-19052-w
http://link.springer.com/article/10.1038/s41467-020-19052-w
Autor:
Ashok Kumar Jayavelu, Sebastian Wolf, Florian Buettner, Gabriela Alexe, Björn Häupl, Federico Comoglio, Constanze Schneider, Carmen Doebele, Dominik C. Fuhrmann, Sebastian Wagner, Elisa Donato, Carolin Andresen, Anne C. Wilke, Alena Zindel, Dominique Jahn, Bianca Splettstoesser, Uwe Plessmann, Silvia Münch, Khali Abou-El-Ardat, Philipp Makowka, Fabian Acker, Julius C. Enssle, Anjali Cremer, Frank Schnütgen, Nina Kurrle, Björn Chapuy, Jens Löber, Sylvia Hartmann, Peter J. Wild, Ilka Wittig, Daniel Hübschmann, Lars Kaderali, Jürgen Cox, Bernhard Brüne, Christoph Röllig, Christian Thiede, Björn Steffen, Martin Bornhäuser, Andreas Trumpp, Henning Urlaub, Kimberly Stegmaier, Hubert Serve, Matthias Mann, Thomas Oellerich
Publikováno v:
Cancer Cell. 40:301-317.e12
Acute myeloid leukemia (AML) is an aggressive blood cancer with a poor prognosis. We report a comprehensive proteogenomic analysis of bone marrow biopsies from 252 uniformly treated AML patients to elucidate the molecular pathophysiology of AML in or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91f0fbad0c2dbf86b9d213e082b7c9f
https://doi.org/10.1016/j.ccell.2022.02.006
https://doi.org/10.1016/j.ccell.2022.02.006
Autor:
Ivan Silbern, Thomas Oellerich, Carmen Doebele, Momchil Ninov, Pan Fang, Henning Urlaub, Kuan-Ting Pan, Christof Lenz, Yanlong Ji
Site-specific regulation of protein N-glycosylation is essential in human cells. However, accurate quantification of glycosylation sites and their individual glycan moieties in a cell-wide manner is still technically challenging. Here, we introduce S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4084e8c401050235e1b8398563a9f7ed
https://doi.org/10.1101/2020.05.20.105726
https://doi.org/10.1101/2020.05.20.105726
Autor:
Jens Kroll, Arthur Zelent, Lothar Rössig, Stefanie Dimmeler, Jes Niels Boeckel, Andreas M. Zeiher, Sabine Gesierich, Hellmut G. Augustin, David Kaluza, Carmen Urbich, Carmen Doebele, Yosif Manavski
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33:533-543
Objective— Histone deacetylases (HDACs) modulate gene expression by deacetylation of histone and nonhistone proteins. Several HDACs control angiogenesis, but the role of HDAC9 is unclear. Methods and Results— Here, we analyzed the function of HDA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61dca31f8c9d9aa1bfdcf6bf3e31c120
https://doi.org/10.1161/atvbaha.112.300415
https://doi.org/10.1161/atvbaha.112.300415
Autor:
Florian Kuchenbauer, Henning Urlaub, Hanibal Bohnenberger, R K Humphries, Carsten Müller-Tidow, Tobias Berg, Arefeh Rouhi, Federico Comoglio, Jasmin Corso, Lars Palmqvist, Thomas Oellerich, Anjali Cremer, Anthony R. Green, Kimberly Stegmaier, Philipp Ströbel, Halvard Bonig, Hubert Serve, Astrid Wachter, Frank Schnütgen, Joachim Beck, Ekkehard Schütz, Timm Schroeder, Sebastian Mohr, Tim Beissbarth, Stefanie Göllner, Michael A. Rieger, Nadine Haetscher, Carmen Doebele, Gabriela Alexe
Publikováno v:
Cancer Cell
Cancer Cell, 31 (4)
Cancer Cell, 31 (4)
Summary The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and Meis1 become a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efacd144f9b8d6f3595037a9fef22cc8
https://pubmed.ncbi.nlm.nih.gov/28399410
https://pubmed.ncbi.nlm.nih.gov/28399410
Autor:
Jürgen Wienands, Hanibal Bohnenberger, Jennifer Hüllein, Federico Comoglio, Sebastian Mohr, Philipp Ströbel, Carmen Doebele, Henning Urlaub, Michael Engelke, Michael A. Rieger, Thorsten Zenz, Jasmin Corso, Thomas Oellerich, Kuan-Ting Pan, Roland Walter, Christof Lenz, Mikolaj Slabicki, Hubert Serve
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Burkitt's lymphoma (BL) is a highly proliferative B-cell neoplasm and is treated with intensive chemotherapy that, because of its toxicity, is often not suitable for the elderly or for patients with endemic BL in developing countries. BL cell surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ead9b1b35bff7b8129046792a448577
https://europepmc.org/articles/PMC4878517/
https://europepmc.org/articles/PMC4878517/
Autor:
Rajkumar Savai, Ariane Fischer, Werner Seeger, Friedrich Grimminger, Soni Savai Pullamsetti, Baktybek Kojonazarov, Carmen Doebele, Ralph T. Schermuly, Bhola K. Dahal, Norbert Weissmann, Andreas M. Zeiher, Hossein Ardeschir Ghofrani, Angelika Bonauer, Stefanie Dimmeler
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 185:409-419
MicroRNAs (miRs) control various cellular processes in tissue homeostasis and disease by regulating gene expression on the posttranscriptional level. Recently, it was demonstrated that the expression of miR-21 and members of the miR-17-92 cluster was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2848082bf0f57f46b9af00b34eec0f75
https://doi.org/10.1164/rccm.201106-1093oc
https://doi.org/10.1164/rccm.201106-1093oc