Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Carmen Cascales"'
Autor:
Dolores Vilella, Isabel Martin, Inmaculada Royo, Keith C. Silverman, Sheo B. Singh, Olga Genilloud, Fernando Pelaez, Manuel Sanchez, Gonzalo Platas, Russell B. Lingham, Carmen Cascales, Oscar Salazar, Hiranthi Jayasuriya, T Díez
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 25:315-327
Mutant ras oncogenes are associated with various human tumors such as pancreas, colon, lung, thyroid, bladder and several types of leukemia. Prenylation of Ras proteins plays a major role in cell proliferation of both normal and cancerous cells. Norm
Autor:
Sheo B. Singh, Keith C. Silverman, Dolores Vilella, Rosalind G. Jenkins, Hiranthi Jayasuriya, Russell B. Lingham, Gerald F. Bills, Carmen Cascales
Publikováno v:
Biochemical and Biophysical Research Communications. 232:478-481
A sulfated tricarboxylic acid fungal metabolite is an inhibitor of human farnesyl-protein transferase (FPTase). The compound, designated as oreganic acid, has a molecular weight of 494, an empirical formula of C22H38O10S and inhibits FPTase with an I
Autor:
Janet M. Sigmund, Isabel Martin, Olga Genilloud, Russell B. Lingham, Magda M. Gagliardi, Brian Heimbuch, Jackson B. Gibbs, Suzanne E. Gartner, Mary Nallin-Omstead, Gregory E. Koch, Sheo B. Singh, George M. Garrity, Carmen Cascales, Manuel Sanchez, Maria Teresa Diez, Charles F. Hirsch, Keith C. Silverman
Publikováno v:
Applied Microbiology and Biotechnology. 43:610-616
Actinoplanic acids A and B are macrocyclic polycarboxylic acids that are potent reversible inhibitors of farnesyl-protein transferase. Actinoplanic acids A and B were isolated from Actinoplanes sp. MA 7066 while actinoplanic acid B was isolated from
Autor:
Susan L. Raghoobar, Russell B. Lingham, Fernando Pelaez, Carmen Cascales, Harry W. Dougherty, Gerald F. Bills, Karst Hoogsteen, Jack L. Smith, Keith C. Silverman, Guy H. Harris
Publikováno v:
Tetrahedron. 49:2139-2144
A novel bistropolone, pycnidione (1), was isolated by bioassay guided fractionation from fermentations of a Phoma sp.. The structure was determined by spectroscopic methods and single crystal X-ray diffraction.
Autor:
Karst Hoogsteen, Jack L. Smith, Keith C. Silverman, Guy H. Harris, Susan L. Raghoobar, Fernando Pelaez, Carmen Cascales, Russell B. Lingham, Harry W. Dougherty, Gerald F. Bills
Publikováno v:
ChemInform. 24
A novel bistropolone, pycnidione (1), was isolated by bioassay guided fractionation from fermentations of a Phoma sp.. The structure was determined by spectroscopic methods and single crystal X-ray diffraction.
Autor:
Hiranthi Jayasuriya, Mary Nallin-Omstead, Suresh B. Singh, Michael A. Goetz, Deborah L. Zink, Rosalind G. Jenkins, Richard G. Ball, Jack L. Smith, Carmen Cascales, Keith C. Silverman, Gerald F. Bills, Russell B. Lingham, Fernando Pelaez
Publikováno v:
ChemInform. 27
Three new diphenyl ethers, barceloneic acids A, B, and barceloneic lactone [1, 2, and 3, respectively] were isolated from a fermentation extract of a fungus of the genus Phoma. The structures of compounds 1-3 were determined by a combination of spect
Autor:
Keith C. Silverman, Michael A. Goetz, Carmen Cascales, Suresh B. Singh, Gerald F. Bills, Hiranthi Jayasuriya, Rosalind G. Jenkins, Russell B. Lingham, Deborah L. Zink
Publikováno v:
ChemInform. 27
Inhibitors of farnesyl-protein transferase (FPTase) have the potential of being anticancer agents for tumors in which ras is found mutated and contributes to cell transformation. From the screening of the extracts of an endophytic fungus isolated fro
Autor:
Sheo B. Singh, Richard G. Ball, Russell B. Lingham, Gerald F. Bills, Deborah L. Zink, Jerrold M. Liesch, Carmen Cascales, Michael A. Goetz, Jackson B. Gibbs, Karst Hoogsteen, Rosalind G. Jenkins, Keith C. Silverman
Publikováno v:
The Journal of organic chemistry. 61(22)
Farnesyl-protein transferase (FPTase) is an enzyme responsible for the farnesylation of Ras protein. Farnesylation is required for cell-transforming activity in several tumor-types, and therefore, inhibition of FPTase activity may be a potential targ
Autor:
Michael A. Goetz, Jack L. Smith, Keith C. Silverman, Suresh B. Singh, Hiranthi Jayasuriya, Rosalind G. Jenkins, Gerald F. Bills, Mary Nallin-Omstead, Carmen Cascales, Fernando Pelaez, Russell B. Lingham, Deborah L. Zink, Richard G. Ball
Publikováno v:
Journal of natural products. 58(7)
Three new diphenyl ethers, barceloneic acids A, B, and barceloneic lactone [1, 2, and 3, respectively] were isolated from a fermentation extract of a fungus of the genus Phoma. The structures of compounds 1-3 were determined by a combination of spect
Autor:
Jon D. Polishook, Russell B. Lingham, Claude Dufresne, Lin Kong, Gregory E. Koch, Isabel Martin, John G. Ondeyka, Jerrold M. Liesch, Tannis M. Jurgens, Ermenegilda McCauley, Hans T. Beck, Robert P. Borris, Carmen Cascales, Steven R. King, Otto D. Hensens, Susan L. Raghoobar, Fernando Pelaez, Michael J. Salvatore, Suzanne E. Gartner, Deborah L. Zink, Maria Teresa Diez, Michael J. Balick, Amy Hsu
Publikováno v:
Journal of natural products. 57(6)
gamma-Pyrone-3-acetic acid (L-741,494) is a novel metabolite produced by a culture of the fungal genus Xylaria. This substance is a water-soluble, competitive, irreversible inhibitor of Interleukin-1 beta Converting Enzyme that is inactive against pa