RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity.

Autor: Martina Proietti Onori, Linda M C Koene, Carmen B Schäfer, Mark Nellist, Marcel de Brito van Velze, Zhenyu Gao, Ype Elgersma, Geeske M van Woerden

Publikováno v: PLoS Biology, Vol 19, Iss 5, p e3001279 (2021)

Hyperactivation of the mammalian target of rapamycin (mTOR) pathway can cause malformation of cortical development (MCD) with associated epilepsy and intellectual disability (ID) through a yet unknown mechanism. Here, we made use of the recently iden

Externí odkaz: https://doaj.org/article/8d4f132af9724879a8c6978f1a598618

Temporal dynamics of the cerebello-cortical convergence in ventro-lateral motor thalamus

Autor: Zhenyu Gao, Freek E. Hoebeek, Chris I. De Zeeuw, Carmen B. Schäfer

Publikováno v: Journal of Physiology-London, 599(7), 2055-2073. Wiley-Blackwell Publishing Ltd
The journal of Physiology
The Journal of physiology, 599, 2055-2073. Wiley-Blackwell
The Journal of Physiology

Key points Ventrolateral thalamus (VL) integrates information from cerebellar nuclei and motor cortical layer VI.Inputs from the cerebellar nuclei evoke large‐amplitude responses that depress upon repetitive stimulation while layer VI inputs from m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbc32f9ec90dce10090482fceaa3bd9
https://pure.eur.nl/en/publications/d112e1dc-12a4-4e8d-83cb-83b9c62057ec

Cerebello-Thalamic Spike Transfer via Temporal Coding and Cortical Adaptation

Autor: Zhenyu Gao, Chris I. De Zeeuw, Freek E. Hoebeek, Carmen B. Schäfer

Orchestrating the ensemble of muscle contractions necessary for coordinated movements requires the interaction of cerebellar, thalamic and cerebral structures, but the mechanisms underlying the integration of information remain largely unknown. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb4e58ad533b4f081001468b977e463
https://doi.org/10.1101/2020.01.19.911610

Convergence of Primary Sensory Cortex and Cerebellar Nuclei Pathways in the Whisker System

Autor: Freek E. Hoebeek, Carmen B. Schäfer

Publikováno v: Neuroscience, 368, 229-239. Elsevier Ltd.

To safely maneuver through the environment the brain needs to compare active sensory information with ongoing motor programs. This process occurs at various levels in the brain: at the lower level, i.e., in the spinal cord, reflexes are generated for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aaeebd3ddd63d96798006b1f3aa6643
https://pure.eur.nl/en/publications/9e12a945-4e58-4a55-ad81-cdb178b17a9d

Atypical resting synchrony in autism spectrum disorder

Autor: Margot J. Taylor, Carmen B. Schäfer, Rachel C. Leung, Annette X. Ye, Sam M. Doesburg

Publikováno v: Human Brain Mapping. 35:6049-6066

Autism spectrum disorder (ASD) is increasingly understood to be associated with aberrant functional brain connectivity. Few studies, however, have described such atypical neural synchrony among specific brain regions. Here, we used magnetoencephalogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da5889639020c88cb3bd17d8898c1afa
https://doi.org/10.1002/hbm.22604