Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Carmen Almansa"'
Autor:
Alba Vidal-Torres, Begoña Fernández-Pastor, Mónica García, Eva Ayet, Anna Cabot, Javier Burgueño, Xavier Monroy, Bertrand Aubel, Xavier Codony, Luz Romero, Rosalía Pascual, Maria Teresa Serafini, Gregorio Encina, Carmen Almansa, Daniel Zamanillo, Manuel Merlos, José Miguel Vela
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 1, Pp 82-99 (2023)
Opioids are the most effective painkillers, but their benefit-risk balance often hinder their therapeutic use. WLB-73502 is a dual, bispecific compound that binds sigma-1 (S1R) and mu-opioid (MOR) receptors. WLB-73502 is an antagonist at the S1R. It
Externí odkaz:
https://doaj.org/article/5db3e49f2136462cbd27dfe08f2a9b36
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The recent publication of the σ1R crystal structure is an important cornerstone for the derivation of more accurate activity prediction models. We report here a comparative study involving a set of more than 25,000 structures from our internal datab
Externí odkaz:
https://doaj.org/article/4c6a3fcb3bb14b6ebe2ca8941d885143
Publikováno v:
Conservation & Society, Vol 14, Iss 3, Pp 243-253 (2016)
The primary aim of this study is to examine the various issues involved in environmental discounting using a Delphi survey of a worldwide panel drawn from specialists in issues relating to discounting and long-term investment evaluation. The environm
Externí odkaz:
https://doaj.org/article/ea39737afbcd460ca4f200c160e35f6b
Autor:
Ariadna Fernández, Enrique Portillo-Salido, Mónica Porras, Adriana Lorente, José Miguel Vela, Carmen Almansa, Raquel Enrech, J.L. Diaz, Begoña Fernández, Albert Dordal, Sergi Rodríguez-Escrich, Raquel F. Reinoso, Mónica García
Publikováno v:
ACS Med Chem Lett
[Image: see text] The synthesis and pharmacological activities of a new series of piperazinyl quinazolin-4-(3H)-one derivatives acting toward the α2δ-1 subunit of voltage-gated calcium channels (Ca(v)α2δ-1) are reported. Different positions of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185ebf310cb9bbc8e97f822502f72c2b
https://doi.org/10.1021/acsmedchemlett.1c00416
https://doi.org/10.1021/acsmedchemlett.1c00416
Autor:
Magda Bordas, Virginia Llorente, Javier Burgueño, Enrique Portillo-Salido, Begoña Fernández, Mónica García, Carmen Almansa, Marta Pujol, Sergi Rodríguez-Escrich, Lourdes Garriga, Georgia Gris, Albert Dordal, Eva Ayet, Ute Christmann, Marina Virgili, José Miguel Vela
Publikováno v:
Journal of Medicinal Chemistry. 64:10139-10154
A new series of propionamide derivatives was developed as dual μ-opioid receptor agonists and σ1 receptor antagonists. Modification of a high-throughput screening hit originated a series of piperazinylcycloalkylmethyl propionamides, which were expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6283a8192c91d9c5578b53eb7b1cb388
https://doi.org/10.1021/acs.jmedchem.1c00417
https://doi.org/10.1021/acs.jmedchem.1c00417
Publikováno v:
Studies of Applied Economics. 26:1-24
Este trabajo muestra los resultados de un estudio Delphi realizado a un panel de 38 expertos españoles con el fin de conocer los enfoques de descuento más idóneos en la evaluación económica de inversiones con implicaciones intergeneracionales. L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47b4db03ee180e0bb50d359e1ec8e7e7
https://doi.org/10.25115/eea.v26i2.5553
https://doi.org/10.25115/eea.v26i2.5553
Autor:
Carmen Almansa, Inés Álvarez, M. Ángeles Sarmentero, José M López-Valbuena, Alba Vidal-Torres, J.L. Diaz, Ana I. Oliva, Raquel Enrech, Daniel Font, Pilar Pérez, Félix Cuevas, Enrique J. Cobos, José Miguel Vela, Cruz Miguel Cendán, Ana Montero, Miquel A. Pericàs, Paula Álvarez-Bercedo, Sandra Yeste
Publikováno v:
Journal of Medicinal Chemistry. 64:5157-5170
The synthesis and pharmacological activity of a new series of 5a,7,8,8a-tetrahydro-4H,6H-pyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine derivatives as potent sigma-1 receptor (σ1R) ligands are reported. A lead optimization program aimed at improvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98ce1cd5a06e15e2388bac29c344b31c
https://doi.org/10.1021/acs.jmedchem.1c00244
https://doi.org/10.1021/acs.jmedchem.1c00244
Autor:
Enrique Portillo-Salido, Agustín Jiménez-Aquino, José Miguel Vela, Ana I. Oliva, Adriana Port, Gonzalo Pazos, Félix Cuevas, María Morón, Carmen Almansa, J.L. Diaz, Albert Dordal, Daniel Font, Raquel F. Reinoso, Paula Álvarez-Bercedo, M. Ángeles Sarmentero, Rosalia Pascual
Publikováno v:
Journal of Medicinal Chemistry. 64:2167-2185
The synthesis and pharmacological activity of a new series of bicyclic diazepinones with dual activity toward the α2δ-1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET) are reported. Exploration of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e44c54c3e5563d8ad6c2a2f01a1d4d
https://doi.org/10.1021/acs.jmedchem.0c01867
https://doi.org/10.1021/acs.jmedchem.0c01867
Autor:
Antoni Torrens, José Miguel Vela, Adriana Lorente, Ana Montero, Sandra Yeste, Ana María Caamaño, Alba Vidal-Torres, J.L. Diaz, Juan Enjo, Miquel Martin, Carmen Almansa, Inés Álvarez, Cristina Sicre, Rafael Maldonado, Mónica García, Adriana Port, Cruz Miguel Cendán, Beatriz de la Puente
Publikováno v:
Journal of Medicinal Chemistry. 63:14979-14988
The synthesis and pharmacological activity of a new series of pyrazoles that led to the identification of 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone (9k, EST64454) as a σ1 receptor (σ1R) antagonist clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748bb7ac3f47098d47adb62f112a37c0
https://doi.org/10.1021/acs.jmedchem.0c01575
https://doi.org/10.1021/acs.jmedchem.0c01575
Autor:
Magda Bordas, Begoña Fernández, Joan Farran, Manuel Merlos, Carmen Almansa, Carlos R. Plata-Salamán, Marina Virgili, Rosalia Pascual, Antonio R. Fernández de Henestrosa, Mónica García, Javier Burgueño, Mònica Alonso, Eva Ayet, José Miguel Vela, Carles Alegret, Alba Vidal-Torres
Publikováno v:
Journal of Medicinal Chemistry. 63:15508-15526
The synthesis and pharmacological activity of a new series of 4-alkyl-1-oxa-4,9-diazaspiro[5.5]undecane derivatives as potent dual ligands for the σ1 receptor (σ1R) and the μ-opioid receptor (MOR) are reported. A lead optimization program over the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0fc5c5a90ba968d0e184bc4837acc30
https://doi.org/10.1021/acs.jmedchem.0c01127
https://doi.org/10.1021/acs.jmedchem.0c01127