Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Carmen, Ruiz de Almodóvar"'
Autor:
Nathalie Tisch, Carolin Mogler, Ana Stojanovic, Robert Luck, Emilia A Korhonen, Alexander Ellerkmann, Heike Adler, Mahak Singhal, Géza Schermann, Lena Erkert, Jay V Patankar, Andromachi Karakatsani, Anna‐Lena Scherr, Yaron Fuchs, Adelheid Cerwenka, Stefan Wirtz, Bruno Christian Köhler, Hellmut G Augustin, Christoph Becker, Thomas Schmidt, Carmen Ruiz de Almodóvar
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 6, Pp 1-21 (2022)
Abstract The gut has a specific vascular barrier that controls trafficking of antigens and microbiota into the bloodstream. However, the molecular mechanisms regulating the maintenance of this vascular barrier remain elusive. Here, we identified Casp
Externí odkaz:
https://doaj.org/article/9ef135c33a444c41ab1845d57c762be3
Autor:
Eva Harde, LaShae Nicholson, Beatriz Furones Cuadrado, Diane Bissen, Sylvia Wigge, Severino Urban, Marta Segarra, Carmen Ruiz de Almodóvar, Amparo Acker-Palmer
Publikováno v:
eLife, Vol 8 (2019)
Vascular endothelial growth factor (VEGF) is an angiogenic factor that play important roles in the nervous system, although it is still unclear which receptors transduce those signals in neurons. Here, we show that in the developing hippocampus VEGFR
Externí odkaz:
https://doaj.org/article/a39f361eeda14c84837251ccdcc9353a
Autor:
Robert Luck, Severino Urban, Andromachi Karakatsani, Eva Harde, Sivakumar Sambandan, LaShae Nicholson, Silke Haverkamp, Rebecca Mann, Ana Martin-Villalba, Erin Margaret Schuman, Amparo Acker-Palmer, Carmen Ruiz de Almodóvar
Publikováno v:
eLife, Vol 8 (2019)
Axon branching is crucial for proper formation of neuronal networks. Although originally identified as an angiogenic factor, VEGF also signals directly to neurons to regulate their development and function. Here we show that VEGF and its receptor VEG
Externí odkaz:
https://doaj.org/article/f35f5089b5394e5fb3f958611d90141c
Autor:
Si Chen, Nathalie Tisch, Marcel Kegel, Rosario Yerbes, Robert Hermann, Hannes Hudalla, Cecilia Zuliani, Gülce Sila Gülcüler, Klara Zwadlo, Jakob von Engelhardt, Carmen Ruiz de Almodóvar, Ana Martin-Villalba
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1378-1393 (2017)
The development of neurons and vessels shares striking anatomical and molecular features, and it is presumably orchestrated by an overlapping repertoire of extracellular signals. CNS macrophages have been implicated in various developmental functions
Externí odkaz:
https://doaj.org/article/f4c6c6f6c1234f02b796243e1b5ae530
Autor:
Patricia Himmels, Isidora Paredes, Heike Adler, Andromachi Karakatsani, Robert Luck, Hugo H. Marti, Olga Ermakova, Eugen Rempel, Esther T. Stoeckli, Carmen Ruiz de Almodóvar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The guidance cues regulating blood vessel patterning in the central nervous system remain unclear. Here, the authors show in mice and chicken developing spinal cord that motor neurons control blood vessel patterning by an autocrine mechanism titratin
Externí odkaz:
https://doaj.org/article/1c485bbbb8e44bb3a721507f6d42678e
Autor:
Soniya Savant, Silvia La Porta, Annika Budnik, Katrin Busch, Junhao Hu, Nathalie Tisch, Claudia Korn, Aida Freire Valls, Andrew V. Benest, Dorothee Terhardt, Xianghu Qu, Ralf H. Adams, H. Scott Baldwin, Carmen Ruiz de Almodóvar, Hans-Reimer Rodewald, Hellmut G. Augustin
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1761-1773 (2015)
Tie1 is a mechanistically poorly characterized endothelial cell (EC)-specific orphan receptor. Yet, Tie1 deletion is embryonic lethal and Tie1 has been implicated in critical vascular pathologies, including atherosclerosis and tumor angiogenesis. Her
Externí odkaz:
https://doaj.org/article/8a8bd19bf7e943c8ba49e7bf3501a59e
Autor:
Ying Shen, Xiaohong Wang, Yi Liu, Mahak Singhal, Can Gürkaşlar, Aida Freire Valls, Yi Lei, Wenjie Hu, Géza Schermann, Heike Adler, Fa-Xing Yu, Tamás Fischer, Yi Zhu, Hellmut G. Augustin, Thomas Schmidt, Carmen Ruiz de Almodóvar
Publikováno v:
Science signaling. 14(712)
The nuclear translocation and activity of the cotranscriptional activators YAP and TAZ (YAP/TAZ) in endothelial cells (ECs) are crucial during developmental angiogenesis. Here, we studied the role of YAP/TAZ signaling in ECs in tumor angiogenesis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c22b35cedb493ca5bfef8558f742c2e
https://pubmed.ncbi.nlm.nih.gov/34874746
https://pubmed.ncbi.nlm.nih.gov/34874746
Autor:
José Ricardo, Vieira, Bhavin, Shah, Sebastian, Dupraz, Isidora, Paredes, Patricia, Himmels, Géza, Schermann, Heike, Adler, Alessia, Motta, Lea, Gärtner, Ariadna, Navarro-Aragall, Elena, Ioannou, Elena, Dyukova, Remy, Bonnavion, Andreas, Fischer, Dario, Bonanomi, Frank, Bradke, Christiana, Ruhrberg, Carmen, Ruiz de Almodóvar
Publikováno v:
Neuron 110(24), 4074-4089.e6 (2022). doi:10.1016/j.neuron.2022.12.005
How the vascular and neural compartment cooperate to achieve such a complex and highly specialized structure as the central nervous system is still unclear. Here, we reveal a crosstalk between motor neurons (MNs) and endothelial cells (ECs), necessar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5097d00d3d38d8643651efba19a1ce7
https://doi.org/10.1016/j.neuron.2022.12.005
https://doi.org/10.1016/j.neuron.2022.12.005
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2013 (2013)
Oxidative Medicine and Cellular Longevity, Vol 2013 (2013)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0748422ac72ba6cf7cc02860462583fe
http://europepmc.org/articles/PMC3859161
http://europepmc.org/articles/PMC3859161
Publikováno v:
Vitamins and hormones. 67
Induction of apoptosis in tumor cells by death receptor activation is a novel therapeutic strategy. However, in systemic antitumor treatments, severe toxic effects have been observed with tumor necrosis factor-alpha (TNF-alpha) and CD95 ligand. TNF-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fae994cbfb71439ce8a9d236d04cc2f8
https://pubmed.ncbi.nlm.nih.gov/15110183
https://pubmed.ncbi.nlm.nih.gov/15110183