OpiCa1-PEG-PLGA nanomicelles antagonize acute heart failure induced by the cocktail of epinephrine and caffeine

Autor: Jun Li, Fei Wang, Xinyan Liu, Zhixiao Yang, Xiaoyu Hua, Hongqiao Zhu, Carmen R. Valdivia, Li Xiao, Songyu Gao, Héctor H. Valdivia, Liang Xiao, Jinming Wang

Publikováno v: Materials Today Bio, Vol 23, Iss , Pp 100859- (2023)

Background: Reducing Ca2+ content in the sarcoplasmic reticulum (SR) through ryanodine receptors (RyRs) by calcin is a potential intervention strategy for the SR Ca2+ overload triggered by β-adrenergic stress in acute heart diseases. Methods: OpiCal

Externí odkaz: https://doaj.org/article/df2e2294dc5d439dab6fcf97292832cc

Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation

Autor: Omid Haji-Ghassemi, Yu Seby Chen, Kellie Woll, Georgina B. Gurrola, Carmen R. Valdivia, Wenxuan Cai, Songhua Li, Hector H. Valdivia, Filip Van Petegem

Publikováno v: Science Advances. 9

Calcins are peptides from scorpion venom with the unique ability to cross cell membranes, gaining access to intracellular targets. Ryanodine Receptors (RyR) are intracellular ion channels that control release of Ca 2+ from the endoplasmic and sarcopl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59b93fe54b62e679f88a1c61584ad883
https://doi.org/10.1126/sciadv.adf4936

The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their responses to cytosolic Ca2+ and Mg2+

Autor: Maria Musgaard, Elisa Venturi, Rebecca Sitsapesan, Ming Lei, Charalampos Sigalas, Jianshu Hu, Carmen R. Valdivia, Abigail D. Wilson, Héctor H. Valdivia

Key points RyR2 mutations can cause type-1 catecholaminergic polymorphic ventricular tachycardia (CPVT1), a lethal, autosomal-dominant arrhythmic disease. However, the changes in RyR2 ion-channel function that result from the many different patient m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856e051f82ca4a632db88c66eec0d104
https://ora.ox.ac.uk/objects/uuid:7421fc54-4b61-4e5e-b05c-68743bb73ce3

Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation

Autor: Yuriana Aguilar-Sanchez, Olivier Villejoubert, Feliciano Protasi, Liheng Yin, Camille Rabesahala de Meritens, Julio L. Álvarez, Pascale Gerbaud, Ernst Niggli, Romain Perrier, Pierre Joanne, Héctor H. Valdivia, F. Anthony Lai, Spyros Zissimopoulos, Riccardo Rizzetto, Esther Zorio, Elena Marques-Sule, Linwei Li, Yue Yi Wang, Yadan Zhang, Alexandra Zahradnikova Jr, Carmen R. Valdivia, Simona Boncompagni, Jean-Pierre Benitah, Valérie Nicolas, Ana Maria Gomez, Josefina Ramos-Franco, Philippe Mateo, Miguel Fernandez-Tenorio

Publikováno v: CIRCULATION RESEARCH
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Circulation Research
Circulation Research, American Heart Association, 2021, 129 (3), pp.e35-e52. ⟨10.1161/CIRCRESAHA.121.319094⟩
Circ Res

Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease, manifested by syncope or sudden death in children or young adults under stress conditions. Mutations in the Ca 2+ release channel/RyR2 (type 2 ryanodine recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e2200fcbc412196d1bcdf3e2b9efab
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=14580

LQTS-associated mutation A257G in α1-syntrophin interacts with the intragenic variant P74L to modify its biophysical phenotype

Autor: Michael J. Ackerman, David J. Tester, Carmen R. Valdivia, Bi-Hua Tan, Jonathan C. Makielski, Matteo Vatta, Argelia Medeiros-Domingo, Jianding Cheng, David W. Van Norstrand

Publikováno v: Cardiogenetics, Vol 1, Iss 1, Pp e13-e13 (2011)

The SNTA1-encoded α1-syntrophin (SNTA1) missense mutation, p.A257G, causes long QT syndrome (LQTS) by pathogenic accentuation of Nav1.5’s sodium current (INa). Subsequently, we found p.A257G in combination with the SNTA1 polymorphism, p.P74L in 4

Externí odkaz: https://doaj.org/article/36be61019c1e42da8b8003167d38a7b0