Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Carmen, Pin"'
Autor:
Louis Gall, Ferran Jardi, Lieve Lammens, Janet Piñero, Terezinha M. Souza, Daniela Rodrigues, Danyel G. J. Jennen, Theo M. deKok, Luke Coyle, Seung‐Wook Chung, Sofia Ferreira, Heeseung Jo, Kylie A. Beattie, Colette Kelly, Carrie A. Duckworth, D. Mark Pritchard, Carmen Pin
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1511-1528 (2023)
Abstract We have built a quantitative systems toxicology modeling framework focused on the early prediction of oncotherapeutic‐induced clinical intestinal adverse effects. The model describes stem and progenitor cell dynamics in the small intestina
Externí odkaz:
https://doaj.org/article/ad07b2f07f9e481a9365795b33099f08
Autor:
Louis Gall, Carrie Duckworth, Ferran Jardi, Lieve Lammens, Aimee Parker, Ambra Bianco, Holly Kimko, David Mark Pritchard, Carmen Pin
Publikováno v:
eLife, Vol 12 (2023)
The maintenance of the functional integrity of the intestinal epithelium requires a tight coordination between cell production, migration, and shedding along the crypt–villus axis. Dysregulation of these processes may result in loss of the intestin
Externí odkaz:
https://doaj.org/article/018bbe6213294175aa395f530f4a00b7
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 9, Pp 498-508 (2020)
Stability analysis, often overlooked in pharmacometrics, is essential to explore dynamical systems. The model developed by Friberg et al.1 to describe drug‐induced hematotoxicity is widely used to support decisions across drug development, and para
Externí odkaz:
https://doaj.org/article/291292eba3d0466999335eab1b98cfea
Autor:
Chiara Fornari, Lenka Oplustil O'Connor, Carmen Pin, Aaron Smith, James W.T. Yates, S.Y. Amy Cheung, Duncan I. Jodrell, Jerome T. Mettetal, Teresa A. Collins
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 11, Pp 858-868 (2019)
Haematological toxicity associated with cancer therapeutics is monitored by changes in blood cell count, and their primary effect is on proliferative progenitors in the bone marrow. Using observations in rat bone marrow and blood, we characterize a m
Externí odkaz:
https://doaj.org/article/5848ecf4800c4426a41a4c13b85eb890
Autor:
Sarah McCallum, Yuuki Obata, Evangelia Fourli, Stefan Boeing, Christopher J Peddie, Qiling Xu, Stuart Horswell, Robert N Kelsh, Lucy Collinson, David Wilkinson, Carmen Pin, Vassilis Pachnis, Tiffany A Heanue
Publikováno v:
eLife, Vol 9 (2020)
The presence and identity of neural progenitors in the enteric nervous system (ENS) of vertebrates is a matter of intense debate. Here, we demonstrate that the non-neuronal ENS cell compartment of teleosts shares molecular and morphological character
Externí odkaz:
https://doaj.org/article/2e57d2f002cf475ba4153d7c9abee0b6
Autor:
Louis Gall, Carrie Duckworth, Ferran Jardi, Lieve Lammens, Aimée Parker, Ambra Bianco, Holly Kimko, D. Mark Pritchard, Carmen Pin
We have built a multi-scale agent-based model (ABM) that reproduces the self-organizing behaviour reported for the intestinal crypt. We demonstrate that a stable spatial organization emerges from the dynamic interaction of multiple signalling pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7723905fe6385cda270248e71fa1440
https://doi.org/10.1101/2022.12.18.520934
https://doi.org/10.1101/2022.12.18.520934
Autor:
Oliver J Maclaren, Aimée Parker, Carmen Pin, Simon R Carding, Alastair J M Watson, Alexander G Fletcher, Helen M Byrne, Philip K Maini
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 7, p e1005688 (2017)
Our work addresses two key challenges, one biological and one methodological. First, we aim to understand how proliferation and cell migration rates in the intestinal epithelium are related under healthy, damaged (Ara-C treated) and recovering condit
Externí odkaz:
https://doaj.org/article/c51090bb4d624b438d20bf4f061ad52c
Autor:
Carmen Pin, Teresa Collins, Aaron Smith, S.Y. Amy Cheung, Lenka Oplustil O'Connor, James W.T. Yates, Duncan I. Jodrell, Jerome T. Mettetal, Chiara Fornari
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 11, Pp 858-868 (2019)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Haematological toxicity associated with cancer therapeutics is monitored by changes in blood cell count, and their primary effect is on proliferative progenitors in the bone marrow. Using observations in rat bone marrow and blood, we characterize a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356e406c6e6461e115ee87ba49953cd9
https://doaj.org/article/5848ecf4800c4426a41a4c13b85eb890
https://doaj.org/article/5848ecf4800c4426a41a4c13b85eb890
Autor:
David G. Wilkinson, Christopher J. Peddie, Sarah McCallum, Stefan Boeing, Vassilis Pachnis, Yuuki Obata, Lucy M. Collinson, Stuart Horswell, Qiling Xu, Carmen Pin, Robert N. Kelsh, Tiffany A. Heanue, Evangelia Fourli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25cee60eab45b99b742df3c2203d2d2c
https://doi.org/10.7554/elife.56086.sa2
https://doi.org/10.7554/elife.56086.sa2
Autor:
Allison Laura Choy, Douglas A. Keller, Matthew F. Peters, Carmen Pin, Kyle L. Kolaja, Radhakrishna Sura, Lorna Ewart, Peggy Guzzie-Peck, Clay W Scott, Derek J. Leishman, Annie Moisan
Publikováno v:
Lab on a chip. 20(7)
Drug-induced gastrointestinal toxicities (DI-GITs) are among the most common adverse events in clinical trials. High prevalence of DI-GIT has persisted among new drugs due in part to the lack of robust experimental tools to allow early detection or t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e320538b399417dfcaef5a1cd406a78a
https://pubmed.ncbi.nlm.nih.gov/32129356
https://pubmed.ncbi.nlm.nih.gov/32129356