Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Carmen, Guaza"'
Autor:
Miriam Mecha, Natalia Yanguas-Casás, Ana Feliú, Leyre Mestre, Francisco Javier Carrillo-Salinas, Kristoffer Riecken, Diego Gomez-Nicola, Carmen Guaza
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Abstract Background The participation of microglia in CNS development and homeostasis indicate that these cells are pivotal for the regeneration that occurs after demyelination. The clearance of myelin debris and the inflammatory-dependent activation
Externí odkaz:
https://doaj.org/article/ce7bb1f9160d489c9a8752ace4649c57
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14378 (2022)
Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune and degenerative disease with axonal damage and demyelination as its main features. Its dual neurological and autoimmune nature makes it a disease that is difficult to treat. Treatments t
Externí odkaz:
https://doaj.org/article/494e57370f0b4e6d9db0f94f369ec4b7
Autor:
Carmen Picón, Amalia Tejeda-Velarde, José Ignacio Fernández-Velasco, Manuel Comabella, Roberto Álvarez-Lafuente, Ester Quintana, Susana Sainz de la Maza, Enric Monreal, Noelia Villarrubia, José Carlos Álvarez-Cermeño, María Inmaculada Domínguez-Mozo, Lluís Ramió-Torrentà, Eulalia Rodríguez-Martín, Ernesto Roldán, Yolanda Aladro, Silvia Medina, Mercedes Espiño, Jaime Masjuan, Clara Matute-Blanch, Marta Muñoz-San Martín, Carmen Espejo, Carmen Guaza, Alfonso Muriel, Lucienne Costa-Frossard, Luisa María Villar
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Patients with multiple sclerosis (MS) suffer with age an early immunosenescence process, which influence the treatment response and increase the risk of infections. We explored whether lipid-specific oligoclonal IgM bands (LS-OCMB) associated with hi
Externí odkaz:
https://doaj.org/article/71044f1e58fe44c598d814aa637e4160
Autor:
Fernando Cavalcanti, Elena Gonzalez-Rey, Mario Delgado, Clara P. Falo, Leyre Mestre, Carmen Guaza, Francisco O’Valle, Michele M. P. Lufino, Jordi Xaus, Cristina Mascaró, Serena Lunardi, Natalia Sacilotto, Paola Dessanti, David Rotllant, Xavier Navarro, Mireia Herrando-Grabulosa, Carlos Buesa, Tamara Maes
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1420 (2022)
Lysine specific demethylase 1 (LSD1; also known as KDM1A), is an epigenetic modulator that modifies the histone methylation status. KDM1A forms a part of protein complexes that regulate the expression of genes involved in the onset and progression of
Externí odkaz:
https://doaj.org/article/df089ff6678843aa91f71f1d603fc7ce
Autor:
Leyre Mestre, Francisco J. Carrillo-Salinas, Ana Feliú, Miriam Mecha, Graciela Alonso, Carmen Espejo, Laura Calvo-Barreiro, José L. Luque-García, Héctor Estevez, Luisa María Villar, Carmen Guaza
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
A growing number of studies support that the bidirectional interactions between the gut microbiota, the immune system and the CNS are relevant for the pathophysiology of MS. Several studies have reported alterations in the gut microbiome of MS patien
Externí odkaz:
https://doaj.org/article/a414281d6f5a4310939b76c402a8b921
Autor:
Carmen Navarrete, Adela García-Martin, Martín Garrido-Rodríguez, Leyre Mestre, Ana Feliú, Carmen Guaza, Marco A. Calzado, Eduardo Muñoz
Publikováno v:
Neurobiology of Disease, Vol 143, Iss , Pp 104994- (2020)
Multiple Sclerosis (MS) is characterized by a combination of inflammatory and neurodegenerative processes in the spinal cord and the brain. Natural and synthetic cannabinoids such as VCE-004.8 have been studied in preclinical models of MS and represe
Externí odkaz:
https://doaj.org/article/2b42990554544d50a9bff731ebb14b53
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
The consistency, efficacy, and safety of cannabis-based medicines have been demonstrated in humans, leading to the approval of the first cannabis-based therapy to alleviate spasticity and pain associated with multiple sclerosis (MS). Indeed, the evid
Externí odkaz:
https://doaj.org/article/98573ea5e3544a43a64226a91fc0af66
Autor:
Carmen Navarrete, Francisco Carrillo-Salinas, Belén Palomares, Miriam Mecha, Carla Jiménez-Jiménez, Leyre Mestre, Ana Feliú, Maria L. Bellido, Bernd L. Fiebich, Giovanni Appendino, Marco A. Calzado, Carmen Guaza, Eduardo Muñoz
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-19 (2018)
Abstract Background Multiple sclerosis (MS) is characterized by a combination of inflammatory and neurodegenerative processes variously dominant in different stages of the disease. Thus, immunosuppression is the goal standard for the inflammatory sta
Externí odkaz:
https://doaj.org/article/2126d9a3cc894214894db216f8403311
Autor:
Leyre Mestre, Francisco Javier Carrillo-Salinas, Miriam Mecha, Ana Feliú, Carmen Espejo, José Carlos Álvarez-Cermeño, Luisa María Villar, Carmen Guaza
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the disease course. Using a well-established model of progressive MS triggered by intracranial in
Externí odkaz:
https://doaj.org/article/7fa42d3b07ce4a6386e2462bb518c2fb
Autor:
Laura Calvo-Barreiro, Herena Eixarch, Manuel Ponce-Alonso, Mireia Castillo, Rafael Lebrón-Galán, Leyre Mestre, Carmen Guaza, Diego Clemente, Rosa del Campo, Xavier Montalban, Carmen Espejo
Publikováno v:
Cells, Vol 9, Iss 4, p 906 (2020)
Previous studies in experimental autoimmune encephalomyelitis (EAE) models have shown that some probiotic bacteria beneficially impact the development of this experimental disease. Here, we tested the therapeutic effect of two commercial multispecies
Externí odkaz:
https://doaj.org/article/b6deee5c63b3455a9fa039ba93dd3855