Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Carmen, Buchrieser"'
Autor:
Rahul Sharma, Michael Adams, Simonne Griffith-Jones, Tobias Sahr, Laura Gomez-Valero, Felix Weis, Michael Hons, Sarah Gharbi, Rayene Berkane, Alexandra Stolz, Carmen Buchrieser, Sagar Bhogaraju
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Legionella pneumophila (LP) secretes more than 300 effectors into the host cytosol to facilitate intracellular replication. One of these effectors, SidH, 253 kDa in size with no sequence similarity to proteins of known function is toxic when
Externí odkaz:
https://doaj.org/article/2d88ff0f17214a348ccac44f567c6f37
Autor:
Clarisse Leseigneur, Carmen Buchrieser
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 4, Pp 151369- (2023)
The study of virulence of Legionella pneumophila and its interactions with its hosts has been predominantly conducted in cellulo in the past decades. Although easy to implement and allowing the dissection of molecular pathways underlying host-pathoge
Externí odkaz:
https://doaj.org/article/b0f386980d624e1dadef03865369ffde
Autor:
Daniel Schator, Sonia Mondino, Jérémy Berthelet, Cristina Di Silvestre, Mathilde Ben Assaya, Christophe Rusniok, Fernando Rodrigues-Lima, Annemarie Wehenkel, Carmen Buchrieser, Monica Rolando
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Legionella pneumophila replicates intracellularly by secreting effectors via a type IV secretion system. One of these effectors is a eukaryotic methyltransferase (RomA) that methylates K14 of histone H3 (H3K14me3) to counteract host immune r
Externí odkaz:
https://doaj.org/article/53cc07086fc84eb580c645d38b21e1d0
Autor:
Monica Rolando, Ivy Yeuk Wah Chung, Caishuang Xu, Laura Gomez-Valero, Patrick England, Miroslaw Cygler, Carmen Buchrieser
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Legionella pneumophila is a bacterial pathogen ubiquitous in natural and man-made aquatic environments, where it replicates in protozoa. Its intracellular life cycle depends on the establishment of a Legionella-containing vacuole (LCV) where
Externí odkaz:
https://doaj.org/article/26ec4e0656494b79ac181002d73bfbb5
Autor:
Arthur Louche, Amandine Blanco, Thais Lourdes Santos Lacerda, Lison Cancade-Veyre, Claire Lionnet, Célia Bergé, Monica Rolando, Frédérique Lembo, Jean-Paul Borg, Carmen Buchrieser, Masami Nagahama, Francine C. A. Gérard, Jean-Pierre Gorvel, Virginie Gueguen-Chaignon, Laurent Terradot, Suzana P. Salcedo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
The bacterium Brucella abortus is an intracellular pathogen that modulates autophagy in host cells. Here, the authors identify two B. abortus effectors that interact with host protease SENP3, thus promoting cytoplasmic accumulation of nucleolar prote
Externí odkaz:
https://doaj.org/article/d17ea5f6891f46cf844a7cebbda821aa
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102175- (2023)
Summary: Regulation of bioenergetics and cell death are pivotal mitochondrial functions determining the responses of macrophages to infection. Here, we provide a protocol to investigate mitochondrial functions during infection of macrophages by intra
Externí odkaz:
https://doaj.org/article/6bc978c5c10243bc9fdc7a6d6c200964
Autor:
Flávia Viana, Laurent Boucontet, Valerio Laghi, Daniel Schator, Marine Ibranosyan, Sophie Jarraud, Emma Colucci-Guyon, Carmen Buchrieser
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011375 (2023)
The zebrafish has become a powerful model organism to study host-pathogen interactions. Here, we developed a zebrafish model to dissect the innate immune response to Legionella pneumophila during infection. We show that L. pneumophila cause zebrafish
Externí odkaz:
https://doaj.org/article/80faad7114e94efcb09fc3f5d57894c8
Autor:
Tobias Sahr, Pedro Escoll, Christophe Rusniok, Sheryl Bui, Gérard Pehau-Arnaudet, Gregory Lavieu, Carmen Buchrieser
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Legionella pneumophila expresses a range of bacterial determinants that mimic eukaryotic functions. Here the authors show small RNAs of L.pneumophila mimic eukaryotic microRNA and modulate the host response to infection.
Externí odkaz:
https://doaj.org/article/3df97bae629b4c4cb76dc65b011ff7e6
Autor:
Viviana Job, Laura Gomez-Valero, Adèle Renier, Christophe Rusniok, Stephanie Bouillot, Viviane Chenal-Francisque, Erwan Gueguen, Annie Adrait, Mylène Robert-Genthon, Katy Jeannot, Peter Panchev, Sylvie Elsen, Marie-Odile Fauvarque, Yohann Couté, Carmen Buchrieser, Ina Attrée
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104596- (2022)
Summary: Two-partner secretion (TPS) is widespread in the bacterial world. The pore-forming TPS toxin ExlA of Pseudomonas aeruginosa is conserved in pathogenic and environmental Pseudomonas. While P. chlororaphis and P. entomophila displayed ExlA-dep
Externí odkaz:
https://doaj.org/article/1309381475d44e2ea91cefe6d018cc0c
Autor:
Pedro Escoll, Lucien Platon, Mariatou Dramé, Tobias Sahr, Silke Schmidt, Christophe Rusniok, Carmen Buchrieser
Publikováno v:
eLife, Vol 10 (2021)
Legionella pneumophila, the causative agent of Legionnaires’ disease, a severe pneumonia, injects via a type 4 secretion system (T4SS) more than 300 proteins into macrophages, its main host cell in humans. Certain of these proteins are implicated i
Externí odkaz:
https://doaj.org/article/61a858dc6ffb4cb69321f87988334e37