Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Carmelo J. Rizzo"'
Selective Incision of the α-N5-Methyl-Formamidopyrimidine Anomer by Escherichia coli Endonuclease IV
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
Formamidopyrimidines (Fapy) lesions result from ring opening of the imidazole portion of purines. Fapy lesions can isomerize from the natural β-anomeric stereochemistry to the α-configuration. We have unambiguously demonstrated that the α-methyl-F
Externí odkaz:
https://doaj.org/article/ff4f5122b16e47a0b68394a152044871
Autor:
Pawel Jaruga, Rachana Tomar, Melis Kant, Vladimir Vartanian, Benjamin Sexton, Carmelo J. Rizzo, Robert J. Turesky, Michael P. Stone, R. Stephen Lloyd, Miral Dizdaroglu
Publikováno v:
ACS Omega. 8:14841-14854
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec51313dee70b87ce0acfcb2592fb480
https://doi.org/10.1021/acsomega.3c01328
https://doi.org/10.1021/acsomega.3c01328
Autor:
Medjda Bellamri, John T. Terrell, Kyle Brandt, Francesca Gruppi, Robert J. Turesky, Carmelo J. Rizzo
Publikováno v:
ACS Chemical Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51fc70895bb1fbc438fb4da7d24004cd
https://doi.org/10.1021/acschembio.3c00033
https://doi.org/10.1021/acschembio.3c00033
Autor:
Philip J. Kingsley, Carmelo J. Rizzo, Plamen P. Christov, Kwangho Kim, Anoop Vemulapalli, Robert L. Eoff, Carol A. Rouzer, Amit Ketkar, Lawrence J. Marnett, Gary A. Sulikowski, Robyn Richie-Jannetta
Publikováno v:
Chemical Research in Toxicology. 34:2567-2578
The lipid peroxidation product malondialdehyde and the DNA peroxidation product base-propenal react with dG to generate the exocyclic adduct, M1dG. This mutagenic lesion has been found in human genomic and mitochondrial DNA. M1dG in genomic DNA is en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::164ccb69984ddbd58c064415de894d3f
https://doi.org/10.1021/acs.chemrestox.1c00334
https://doi.org/10.1021/acs.chemrestox.1c00334
Kinetics of DNA Adducts and Abasic Site Formation in Tissues of Mice Treated with a Nitrogen Mustard
Autor:
Robert J. Turesky, Lihua Yao, Leila Hejazi, Ziyou Cui, Carmelo J. Rizzo, Scott J. Walmsley, Haoqing Chen
Publikováno v:
Chem Res Toxicol
Nitrogen mustards (NM) are an important class of chemotherapeutic drugs used in the treatment of malignant tumors. The accepted mechanism of action of NM is through the alkylation of DNA bases. NM-adducts block DNA replication in cancer cells by form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86769dc722238bdb50975af9bd025b99
https://doi.org/10.1021/acs.chemrestox.0c00012
https://doi.org/10.1021/acs.chemrestox.0c00012
Autor:
Plamen P, Christov, Robyn, Richie-Jannetta, Philip J, Kingsley, Anoop, Vemulapalli, Kwangho, Kim, Gary A, Sulikowski, Carmelo J, Rizzo, Amit, Ketkar, Robert L, Eoff, Carol A, Rouzer, Lawrence J, Marnett
Publikováno v:
Chemical research in toxicology. 34(12)
The lipid peroxidation product malondialdehyde and the DNA peroxidation product base-propenal react with dG to generate the exocyclic adduct, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ec6c6dd254cc504dbea58cc6e345048
https://pubmed.ncbi.nlm.nih.gov/34860508
https://pubmed.ncbi.nlm.nih.gov/34860508
Autor:
Pratibha P, Ghodke, Jyotirling R, Mali, Amritraj, Patra, Carmelo J, Rizzo, F Peter, Guengerich, Martin, Egli
Publikováno v:
The Journal of Biological Chemistry
Etheno (ε)-adducts, e.g., 1,N2-ε−guanine (1,N2-ε-G) and 1,N6-ε−adenine (1,N6-ε-A), are formed through the reaction of DNA with metabolites of vinyl compounds or with lipid peroxidation products. These lesions are known to be mutagenic, but i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::45ed173b81a8588859e7de392898885b
https://pubmed.ncbi.nlm.nih.gov/33839151
https://pubmed.ncbi.nlm.nih.gov/33839151
Publikováno v:
Journal of Biological Chemistry. 292:18790-18799
Nitrogen mustards (NMs) are DNA-alkylating compounds that represent the earliest anticancer drugs. However, clinical use of NMs is limited because of their own mutagenic properties. The mechanisms of NM-induced mutagenesis remain unclear. The major p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6051685bb05ff22bf53c15616e17b6d7
https://doi.org/10.1074/jbc.m117.802520
https://doi.org/10.1074/jbc.m117.802520
Publikováno v:
Environmental and Molecular Mutagenesis. 58:182-189
Addition of hydroxyl radicals to the C8 position of 2'-deoxyguanosine generates an 8-hydroxyguanyl radical that can be converted into either 8-oxo-7,8-dihydro-2'-deoxyguanosine or N-(2-deoxy-d-pentofuranosyl)-N-(2,6-diamino-4-hydroxy-5-formamidopyrim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3508ae77b710dae2867bebc9dbf95198
https://doi.org/10.1002/em.22089
https://doi.org/10.1002/em.22089
Autor:
Plamen P. Christov, Robyn Richie-Jannetta, Philip J. Kingsley, Anoop Vemulapalli, Kwangho Kim, Gary A. Sulikowski, Carmelo J. Rizzo, Amit Ketkar, Robert L. Eoff, Carol A. Rouzer, Lawrence J. Marnett
Publikováno v:
Chemical Research in Toxicology; 12/20/2021, Vol. 34 Issue 12, p2567-2578, 12p