Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Carmelo García‐Monzón"'
Autor:
Patricia Rada, Elena Carceller-López, Ana B. Hitos, Beatriz Gómez-Santos, Constanza Fernández-Hernández, Esther Rey, Julia Pose-Utrilla, Carmelo García-Monzón, Águeda González-Rodríguez, Guadalupe Sabio, Antonia García, Patricia Aspichueta, Teresa Iglesias, Ángela M. Valverde
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102045- (2024)
Objectives: Protein kinase D (PKD) family is emerging as relevant regulator of metabolic homeostasis. However, the precise role of PKD2 in modulating hepatic insulin signaling has not been fully elucidated and it is the aim of this study. Methods: PK
Externí odkaz:
https://doaj.org/article/abf0bce88beb4a23b4cb4540fea29630
Autor:
Patricia Marañón, Esther Rey, Stephania C. Isaza, Hanghang Wu, Patricia Rada, Carmen Choya-Foces, Antonio Martínez-Ruiz, María Ángeles Martín, Sonia Ramos, Carmelo García-Monzón, Francisco Javier Cubero, Ángela M. Valverde, Águeda González-Rodríguez
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103088- (2024)
Acetaminophen (APAP)-induced liver injury is one of the most prevalent causes of acute liver failure (ALF). We assessed the role of the bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 in APAP-induced hepatotoxicity. The molecular mech
Externí odkaz:
https://doaj.org/article/dfecb0de4ea14159adf701f783671f60
Autor:
Patricia Marañón, Stephania C. Isaza, Carlos Ernesto Fernández-García, Esther Rey, Rocío Gallego-Durán, Rocío Montero-Vallejo, Javier Rodríguez de Cía, Javier Ampuero, Ángela M. Valverde, Manuel Romero-Gómez, Carmelo García-Monzón, Águeda González-Rodríguez
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Background & Aims Advanced hepatic fibrosis is the main risk factor of liver-related morbidity and mortality in patients with chronic liver disease. In this study, we assessed the potential role of bone morphogenetic protein 8A (BMP8A) as a
Externí odkaz:
https://doaj.org/article/8bdf154a44f54c48aa9adb7e918626e3
Autor:
Pedro Landete, Carlos Ernesto Fernández-García, José M. Muñoz, Alfonsi Friera, Julio Ancochea, Águeda González-Rodríguez, Carmelo García-Monzón
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundLittle is known about whether the overlap syndrome (OS) combining features of chronic obstructive pulmonary disease (COPD) and sleep apnea-hypopnea syndrome increases the risk of stroke associated with COPD itself.MethodsWe prospectively st
Externí odkaz:
https://doaj.org/article/93e793758437441aa787b10f90789f37
Autor:
Patricia Marañón, Carlos Ernesto Fernández-García, Stephania C. Isaza, Esther Rey, Rocío Gallego-Durán, Rocío Montero-Vallejo, Javier Rodríguez de Cía, Javier Ampuero, Manuel Romero-Gómez, Carmelo García-Monzón, Águeda González-Rodríguez
Publikováno v:
Biomarker Research, Vol 10, Iss 1, Pp 1-10 (2022)
Abstract Background Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease worldwide, being non-alcoholic steatohepatitis (NASH) its most clinically relevant form. Given the risks associated with taking a liver biop
Externí odkaz:
https://doaj.org/article/205b4344f61f456098437edb33a7af9e
Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation
Autor:
Rocío Gallego-Durán, Javier Ampuero, Helena Pastor-Ramírez, Leticia Álvarez-Amor, Jose Antonio del Campo, Douglas Maya-Miles, Rocío Montero-Vallejo, Antonio Cárdenas-García, Mª Jesús Pareja, Sheila Gato-Zambrano, Raquel Millán, María del Carmen Rico, Amparo Luque-Sierra, Antonio Gil-Gómez, Ángela Rojas, Rocío Muñoz-Hernández, María García-Lozano, Rocío Aller, Raúl J. Andrade, Carmelo García-Monzón, Fausto Andreola, Francisco Martín, Rajiv Jalan, Manuel Romero-Gómez
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking this entity. Seventeen liver specimens from NAFLD patients were included for immunohistochemistry and gene expression
Externí odkaz:
https://doaj.org/article/6b0034b1492945a5bad81e9db024ea51
Autor:
Lucía Barbier-Torres, Karen A. Fortner, Paula Iruzubieta, Teresa C. Delgado, Emily Giddings, Youdinghuan Chen, Devin Champagne, David Fernández-Ramos, Daniela Mestre, Beatriz Gomez-Santos, Marta Varela-Rey, Virginia Gutiérrez de Juan, Pablo Fernández-Tussy, Imanol Zubiete-Franco, Carmelo García-Monzón, Águeda González-Rodríguez, Dhaval Oza, Felipe Valença-Pereira, Qian Fang, Javier Crespo, Patricia Aspichueta, Frederic Tremblay, Brock C. Christensen, Juan Anguita, María Luz Martínez-Chantar, Mercedes Rincón
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Non-alcoholic fatty liver (NAFLD) disease causes degeneration of the liver, affects about 25% of people globally, and has no approved treatment. Here, the authors show that the therapeutic siRNA-driven silencing of MCJ in the liver is an effective an
Externí odkaz:
https://doaj.org/article/f4585c15ec8641c2ad4a105f86c1a9ca
Autor:
Pedro Landete, Carlos Ernesto Fernández-García, Beatriz Aldave-Orzaiz, Marta Hernández-Olivo, Carmen M. Acosta-Gutiérrez, Enrique Zamora-García, Julio Ancochea, Águeda González-Rodríguez, Carmelo García-Monzón
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
IntroductionGiven that obstructive sleep apnea (OSA) is commonly associated with metabolic disorders, in this prospective study, we sought to determine the prevalence and risk factors for hepatosteatosis, non-alcoholic steatohepatitis (NASH), and adv
Externí odkaz:
https://doaj.org/article/430de82f9bb24490b26742eef4c1c71b
Autor:
Ainara Cano, Mercedes Vazquez-Chantada, Javier Conde-Vancells, Aintzane Gonzalez-Lahera, David Mosen-Ansorena, Francisco J. Blanco, Karine Clément, Judith Aron-Wisnewsky, Albert Tran, Philippe Gual, Carmelo García-Monzón, Joan Caballería, Azucena Castro, María Luz Martínez-Chantar, José M. Mato, Huiping Zhu, Richard H. Finnell, Ana M. Aransay
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 337 (2023)
Low serum folate levels are inversely related to metabolic associated fatty liver disease (MAFLD). The role of the folate transporter gene (SLC19A1) was assessed to clarify its involvement in lipid accumulation during the onset of MAFLD in humans and
Externí odkaz:
https://doaj.org/article/604e1f5cef3f4e0f877c63c8750f776b
Autor:
Andrea R. López-Pastor, Jorge Infante-Menéndez, Tamara González-Illanes, Paula González-López, Águeda González-Rodríguez, Carmelo García-Monzón, Melina Vega de Céniga, Leticia Esparza, Almudena Gómez-Hernández, Óscar Escribano
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 12 (2021)
The prevalence of non-alcoholic fatty liver disease (NAFLD) is constantly increasing, and altered expression of microRNAs (miRNAs) fosters the development and progression of many pathologies, including NAFLD. Therefore, we explored the role of new mi
Externí odkaz:
https://doaj.org/article/8bbf6bc2f91e4bf8b1f7af218f975942