Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Carmela Speciale"'
Publikováno v:
Experimental Brain Research. 141:389-397
Intracerebral infusion of 3-hydroxyanthranilate (3HANA) rapidly increases the brain content of the endogenous excitotoxin quinolinate (QUIN). QUIN formation from 3HANA is readily prevented by coadministration of the specific 3-hydroxyanthranilate oxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f42468e6a3771603f0a879f03fea03b
https://doi.org/10.1007/s002210100887
https://doi.org/10.1007/s002210100887
Autor:
Vittorio Pinciroli, Massimo Cini, Felicita Greco, Mario Varasi, Arturo Della Torre, Carmela Speciale, Salvatore Toma, Paolo Pevarello, Antonio Pillan, Franco Heidempergher, Marina Marconi
Publikováno v:
Il Farmaco. 54:152-160
A series of pyrrolo[3,2-c]quinoline derivatives were synthesised and evaluated as inhibitors of selected enzymes of the kynurenine pathway. 7-Chloro-3-methyl-1H-pyrrolo[3,2-c]quinoline-4-carboxylic acid (7a) was found to be a relatively potent and se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a53f6f0d4074b8258714c827e372d63
https://doi.org/10.1016/s0014-827x(99)00009-9
https://doi.org/10.1016/s0014-827x(99)00009-9
Autor:
Carmela Speciale, Massimo Cini, Salvatore Toma, R. Bormetti, Paolo Pevarello, Mario Varasi, Antonio Giordani, Felicita Greco
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2907-2912
Kynurenine 3-hydroxylase (KYN 3-OHase) is a key enzyme in the kynurenine pathway of tryptophan degradation and its inhibition may be an effective mechanism for counteracting neuronal excitotoxic damage. We present here a new class of inhibitors deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b80d2f540ecd03f8ba2411cd73b546
https://doi.org/10.1016/s0960-894x(98)00517-4
https://doi.org/10.1016/s0960-894x(98)00517-4
Autor:
Liviana Cozzi, Monica Mosca, Robert Schwarcz, Luca Benatti, Carmela Speciale, Etsuo Okuno, Jerome Breton
Publikováno v:
FEBS Letters. 353:21-24
The enzyme kynurenine aminotransferase (KAT) catalyses the conversion of l-kynurenine to kynurenic acid. A combination of polymerase chain reaction techniques and hybridization screening was used to isolate a cDNA clone encompassing the entire coding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18e1fec15a530bce6d5727f6cb3db39
https://doi.org/10.1016/0014-5793(94)01003-x
https://doi.org/10.1016/0014-5793(94)01003-x
ChemInform Abstract: 4-Phenyl-4-oxo-butanoic Acid Derivatives Inhibitors of Kynurenine 3-Hydroxylase
Autor:
Antonio Giordani, Carmela Speciale, Mario Varasi, Paolo Pevarello, R. Bormetti, Felicita Greco, Salvatore Toma, Massimo Cini
Publikováno v:
ChemInform. 30
Kynurenine 3-hydroxylase (KYN 3-OHase) is a key enzyme in the kynurenine pathway of tryptophan degradation and its inhibition may be an effective mechanism for counteracting neuronal excitotoxic damage. We present here a new class of inhibitors deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38bebeb306ae8037727a241a6679b913
https://doi.org/10.1002/chin.199906082
https://doi.org/10.1002/chin.199906082
Autor:
Roberto, Pellicciari, Laura, Amori, Gabriele, Costantino, Antonio, Giordani, Antonio, Macchiarulo, Luisa, Mattoli, Paolo, Pevarello, Carmela, Speciale, Mario, Varasi
Publikováno v:
Advances in experimental medicine and biology. 527
A novel potent and selective kynurenine-3-hydroxylase inhibitor is descibed along a preliminary evaluation in a in vivo gerbil model of its ability to increase the kynurenine and kynurenic acid concentration in both plasma and brain. These data suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f4cacd82d2210a2811b0cb4a276ceb8
https://pubmed.ncbi.nlm.nih.gov/15206781
https://pubmed.ncbi.nlm.nih.gov/15206781
Autor:
Mario Varasi, G. Ceresoli-Borroni, Robert Schwarcz, Paolo Guidetti, Carmela Speciale, Helen E. Scharfman, J. H. Goodman, Hui-Qiu Wu
Publikováno v:
Neuroscience. 97(2)
Competing enzymatic mechanisms degrade the tryptophan metabolite l -kynurenine to kynurenate, an inhibitory and neuroprotective compound, and to the neurotoxins 3-hydroxykynurenine and quinolinate. Kynurenine 3-hydroxylase inhibitors such as PNU 1565
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7577734e3ab8955fda8af40ea82f9c56
https://pubmed.ncbi.nlm.nih.gov/10799756
https://pubmed.ncbi.nlm.nih.gov/10799756
Autor:
Liviana Cozzi, Nilla Avanzi, Salvatore Toma, Silvia Gatti, Shigenobu Tone, Masayuki Nakamura, Carmela Speciale, Etsuo Okuno, Luca Benatti, Ryo Kido, Jerome Breton, Marina Mostardini
Publikováno v:
FEBS letters. 408(1)
Kynureninase [E.C.3.7.1.3.] is one of the enzymes involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. By tryptic and CNBr digestion of purified rat liver kynureninase, we obtained about 28% of the amino acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21633654a8c33c5b7bc1d103e770375f
https://pubmed.ncbi.nlm.nih.gov/9180257
https://pubmed.ncbi.nlm.nih.gov/9180257
Publikováno v:
European journal of pharmacology. 315(3)
Kynurenic acid is an endogenous excitatory amino-acid receptor antagonist with neuroprotective and anticonvulsant properties. We demonstrate here that systemic administration of the new and potent kynurenine 3-hydroxylase inhibitor (R,S)-3,4-dichloro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464d9fdbeffabf68c82c510245d80588
https://pubmed.ncbi.nlm.nih.gov/8982663
https://pubmed.ncbi.nlm.nih.gov/8982663
Autor:
Robert Schwarcz, A. Molinari, C Caccia, L Curatolo, Carmela Speciale, M. Cini, M. Marconi, L Raimondi
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461380269
Kynurenines, i.e. tryptophan metabolites along the kynurenine pathway, have recently received attention because of their possible role in the immunocompromised brain and in the pathogenesis of human neurodegenerative diseases (Stone, 1993). In partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::251a70a04f9acfc70d19444584a27984
https://doi.org/10.1007/978-1-4613-0381-7_43
https://doi.org/10.1007/978-1-4613-0381-7_43
