Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Carmela Sidrauski"'
Autor:
Katherine Labbé, Lauren LeBon, Bryan King, Ngoc Vu, Emily H. Stoops, Nina Ly, Austin E. Y. T. Lefebvre, Phillip Seitzer, Swathi Krishnan, Jin-Mi Heo, Bryson Bennett, Carmela Sidrauski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The integrated stress response (ISR) enables cells to cope with a variety of insults, but its specific contribution to downstream cellular outputs remains unclear. Using a synthetic tool, we selectively activate the ISR without co-activation
Externí odkaz:
https://doaj.org/article/27e86f13e45248efb23da08ad179a50a
Autor:
Qi Hao, Jin-Mi Heo, Boguslaw P. Nocek, Kevin G. Hicks, Vincent S. Stoll, Clint Remarcik, Sean Hackett, Lauren LeBon, Rinku Jain, Dan Eaton, Jared Rutter, Yao Liang Wong, Carmela Sidrauski
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link betw
Externí odkaz:
https://doaj.org/article/7dab3274bc6948168fa0acd7979be94e
Autor:
Yao Liang Wong, Lauren LeBon, Ana M Basso, Kathy L Kohlhaas, Arthur L Nikkel, Holly M Robb, Diana L Donnelly-Roberts, Janani Prakash, Andrew M Swensen, Nimrod D Rubinstein, Swathi Krishnan, Fiona E McAllister, Nicole V Haste, Jonathon J O'Brien, Margaret Roy, Andrea Ireland, Jennifer M Frost, Lei Shi, Stephan Riedmaier, Kathleen Martin, Michael J Dart, Carmela Sidrauski
Publikováno v:
eLife, Vol 8 (2019)
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://doaj.org/article/7ff3f238f99040afb97c2dc3b9419d6e
Publikováno v:
eLife, Vol 7 (2018)
eIF2B is a dedicated guanine nucleotide exchange factor for eIF2, the GTPase that is essential to initiate mRNA translation. The integrated stress response (ISR) signaling pathway inhibits eIF2B activity, attenuates global protein synthesis and upreg
Externí odkaz:
https://doaj.org/article/83d84271b4b942fab5fece615d525f1f
Autor:
Andon N Placzek, David L Molfese, Sanjeev Khatiwada, Gonzalo Viana Di Prisco, Wei Huang, Carmela Sidrauski, Krešimir Krnjević, Christopher L Amos, Russell Ray, John A Dani, Peter Walter, Ramiro Salas, Mauro Costa-Mattioli
Publikováno v:
eLife, Vol 5 (2016)
Adolescents are particularly vulnerable to nicotine, the principal addictive component driving tobacco smoking. In a companion study, we found that reduced activity of the translation initiation factor eIF2α underlies the hypersensitivity of adolesc
Externí odkaz:
https://doaj.org/article/7bccc1d1a2ab4551bb9823905f9b2c4a
Autor:
Wei Huang, Andon N Placzek, Gonzalo Viana Di Prisco, Sanjeev Khatiwada, Carmela Sidrauski, Krešimir Krnjević, Peter Walter, John A Dani, Mauro Costa-Mattioli
Publikováno v:
eLife, Vol 5 (2016)
Adolescents are especially prone to drug addiction, but the underlying biological basis of their increased vulnerability remains unknown. We reveal that translational control by phosphorylation of the translation initiation factor eIF2α (p-eIF2α) a
Externí odkaz:
https://doaj.org/article/5223255eb24d4ac9a59a9011b8cfdfc1
Autor:
Aaron S Mendez, Jennifer Alfaro, Marisol A Morales-Soto, Arvin C Dar, Emma McCullagh, Katja Gotthardt, Han Li, Diego Acosta-Alvear, Carmela Sidrauski, Alexei V Korennykh, Sebastian Bernales, Kevan M Shokat, Peter Walter
Publikováno v:
eLife, Vol 4 (2015)
Two ER membrane-resident transmembrane kinases, IRE1 and PERK, function as stress sensors in the unfolded protein response. IRE1 also has an endoribonuclease activity, which initiates a non-conventional mRNA splicing reaction, while PERK phosphorylat
Externí odkaz:
https://doaj.org/article/4bb32bbcaa164101ab39039acd5508e5
Autor:
Carmela Sidrauski, Jordan C Tsai, Martin Kampmann, Brian R Hearn, Punitha Vedantham, Priyadarshini Jaishankar, Masaaki Sokabe, Aaron S Mendez, Billy W Newton, Edward L Tang, Erik Verschueren, Jeffrey R Johnson, Nevan J Krogan, Christopher S Fraser, Jonathan S Weissman, Adam R Renslo, Peter Walter
Publikováno v:
eLife, Vol 4 (2015)
The general translation initiation factor eIF2 is a major translational control point. Multiple signaling pathways in the integrated stress response phosphorylate eIF2 serine-51, inhibiting nucleotide exchange by eIF2B. ISRIB, a potent drug-like smal
Externí odkaz:
https://doaj.org/article/12e8ad8456444891baa5b27de57a8417
Publikováno v:
eLife, Vol 4 (2015)
Previously, we identified ISRIB as a potent inhibitor of the integrated stress response (ISR) and showed that ISRIB makes cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (Sidrauski et al., 2013). Here
Externí odkaz:
https://doaj.org/article/36eb64b79fb84a918ae09797c5b324c3
Autor:
Carmela Sidrauski, Diego Acosta-Alvear, Arkady Khoutorsky, Punitha Vedantham, Brian R Hearn, Han Li, Karine Gamache, Ciara M Gallagher, Kenny K-H Ang, Chris Wilson, Voytek Okreglak, Avi Ashkenazi, Byron Hann, Karim Nader, Michelle R Arkin, Adam R Renslo, Nahum Sonenberg, Peter Walter
Publikováno v:
eLife, Vol 2 (2013)
Phosphorylation of the α-subunit of initiation factor 2 (eIF2) controls protein synthesis by a conserved mechanism. In metazoa, distinct stress conditions activate different eIF2α kinases (PERK, PKR, GCN2, and HRI) that converge on phosphorylating
Externí odkaz:
https://doaj.org/article/8e9e1b8dba294563a7f482f53248b47c