Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Carmela R Abraham"'
Autor:
Ci-Di Chen, Yuexuan Li, Arthur K Chen, Melissa A Rudy, Jason S Nasse, Ella Zeldich, Taryn J Polanco, Carmela R Abraham
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226382 (2020)
Klotho is an age-extending, cognition-enhancing protein found to be down-regulated in aged mammals when age-related diseases start to appear. Low levels of Klotho occur in neurodegenerative diseases, kidney disease and many cancers. Many normal and p
Externí odkaz:
https://doaj.org/article/4bfff10d5b234cd68fb0ae137b1cc0f3
Autor:
Emer R McGrath, Jayandra J Himali, Daniel Levy, Sarah C Conner, Matthew P Pase, Carmela R Abraham, Paul Courchesne, Claudia L Satizabal, Ramachandran S Vasan, Alexa S Beiser, Sudha Seshadri
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213321 (2019)
BackgroundFibroblast growth factor 23 is an emerging vascular biomarker, recently associated with cerebral small vessel disease and poor cognition in patients on dialysis. It also interacts with klotho, an anti-aging and cognition enhancing protein.O
Externí odkaz:
https://doaj.org/article/a50afaea5ab64c50b6c3e00afbed08c4
Autor:
Serafima Dubnov, Estelle R. Bennett, Nadav Yayon, Or Yakov, David A. Bennett, Sudha Seshadri, Elliott Mufson, Yonat Tzur, David Greenberg, Makoto Kuro-o, Iddo Paldor, Carmela R. Abraham, Hermona Soreq
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Overexpression of the longevity gene Klotho prolongs lifespan, while its knockout shortens lifespan and impairs cognition via perturbation of myelination and synapse formation. However, comprehensive analysis of Klotho knockout effects on ma
Externí odkaz:
https://doaj.org/article/3ebc2e4dc2b14899a640933ae8c12b98
Autor:
Joan Roig-Soriano, Cristina Sánchez-de-Diego, Jon Esandi-Jauregui, Sergi Verdés, Carmela R. Abraham, Assumpció Bosch, Francesc Ventura, Miguel Chillón
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The aging-protective gene α-Klotho (KL) produces two main transcripts. The full-length mRNA generates a transmembrane protein that after proteolytic ectodomain shedding can be detected in serum as processed Klotho (p-KL), and a shorter tran
Externí odkaz:
https://doaj.org/article/6d0e213469a84004ae0d9ef85a56bf58
Autor:
Carmela R. Abraham, Anne Li
Publikováno v:
Ageing research reviews. 82
The protein Klotho (KL) was first discovered in KL-deficient mice, which developed a syndrome similar to premature aging in humans. Since then, KL has been implicated in multiple molecular signaling pathways and diseases. KL has been shown to have an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9984119ad477fe7d9462902c907df94c
https://pubmed.ncbi.nlm.nih.gov/36283617
https://pubmed.ncbi.nlm.nih.gov/36283617
Autor:
Dena B. Dubal, Jennifer S. Yokoyama, Lei Zhu, Lauren Broestl, Kurtresha Worden, Dan Wang, Virginia E. Sturm, Daniel Kim, Eric Klein, Gui-Qiu Yu, Kaitlyn Ho, Kirsten E. Eilertson, Lei Yu, Makoto Kuro-o, Philip L. De Jager, Giovanni Coppola, Gary W. Small, David A. Bennett, Joel H. Kramer, Carmela R. Abraham, Bruce L. Miller, Lennart Mucke
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1065-1076 (2014)
Aging is the primary risk factor for cognitive decline, an emerging health threat to aging societies worldwide. Whether anti-aging factors such as klotho can counteract cognitive decline is unknown. We show that a lifespan-extending variant of the hu
Externí odkaz:
https://doaj.org/article/f7e79af4e7e64a0c94ccb77027792065
Autor:
Saverio Bellusci, Kenneth S. Kosik, Giovanni Coppola, Mohsen Ghanbari, Deborah Kim, Israel Hernandez, Kerstin Goth, Brent L. Fogel, Kathie J. Ngo, M. Arfan Ikram, Steven A. Kushner, Ci-Di Chen, Jason D Hinman, Riki Kawaguchi, Carmela R. Abraham
Publikováno v:
Hum Mol Genet
Human molecular genetics, vol 30, iss 1
Human Molecular Genetics, 30(1), 103-118. Oxford University Press
Human molecular genetics, vol 30, iss 1
Human Molecular Genetics, 30(1), 103-118. Oxford University Press
Oligodendrocytes exist in a heterogenous state and are implicated in multiple neuropsychiatric diseases including dementia. Cortical oligodendrocytes are a glial population uniquely positioned to play a key role in neurodegeneration by synchronizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40ac2473bf3856e566832b2c1167d33
https://doi.org/10.1093/hmg/ddaa252
https://doi.org/10.1093/hmg/ddaa252
Autor:
Tammi Arbel Rubinstein, Inbal Reuveni, Arkadi Hesin, Anat Klein-Goldberg, Hannes Olauson, Tobias E. Larsson, Carmela R. Abraham, Ella Zeldich, Assumpció Bosch, Miguel Chillón, Kenneth Samuel Hollander, Ayelet Shabtay-Orbach, Gilad W. Vainer, Ido Wolf, Tami Rubinek
Publikováno v:
Cancers, Vol 13, Iss 6297, p 6297 (2021)
Cancers; Volume 13; Issue 24; Pages: 6297
Cancers
Scientia
Cancers; Volume 13; Issue 24; Pages: 6297
Cancers
Scientia
Simple Summary We aimed to study the role of the anti-aging protein klotho and its secreted isoform, sKL, in pancreatic cancer. Three in vivo models, including a novel genetic mouse model and bioinformatics analyses, indicated klotho as a tumor suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7840f90fb214a509b478b4a541aae8
https://www.mdpi.com/2072-6694/13/24/6297
https://www.mdpi.com/2072-6694/13/24/6297
Autor:
Nelson C. Lau, Bryce Howat, Anthony G. Lambert, Theo Hatzipetros, Ann C. McKee, Qicheng Ma, Ci-Di Chen, Dean Zeldich, Emma Boden, Ella Zeldich, Carmela R. Abraham, Jason S. Nasse, Jonathan D. Cherry, Rebecca M. Mathias, Andrea Yuste
Publikováno v:
Journal of Molecular Neuroscience. 69:264-285
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of motor neurons in the brain and spinal cord. ALS neuropathology is associated with increased oxidative stress, excitotoxicity, and inflammatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb7a3a07ad1a089f894311907c475f99
https://doi.org/10.1007/s12031-019-01356-2
https://doi.org/10.1007/s12031-019-01356-2
Autor:
Jaclyn Garza Grenier, Dana Fein-Schaffer, Zhenwei Zhou, Erika J. Wolf, Annjanette Stone, Ci-Di Chen, Bertrand R. Huber, Filomene G. Morrison, Nikolaos P. Daskalakis, Mark W. Logue, Xiang Zhao, Steven A. Schichman, Carmela R. Abraham, Mark W. Miller
Publikováno v:
Neuropsychopharmacology
This study examined the klotho (KL) longevity gene polymorphism rs9315202 and psychopathology, including posttraumatic stress disorder (PTSD), depression, and alcohol-use disorders, in association with advanced epigenetic age in three postmortem cort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2dbaae959f2b48306a08336b225df10
https://pubmed.ncbi.nlm.nih.gov/33096543
https://pubmed.ncbi.nlm.nih.gov/33096543