Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Carmela Parenti"'
Autor:
Rita Turnaturi, Silvia Piana, Salvatore Spoto, Giuliana Costanzo, Lorena Reina, Lorella Pasquinucci, Carmela Parenti
Publikováno v:
Molecules, Vol 29, Iss 4, p 815 (2024)
Pain is associated with many health problems and a reduced quality of life and has been a common reason for seeking medical attention. Several therapeutics are available on the market, although side effects, physical dependence, and abuse limit their
Externí odkaz:
https://doaj.org/article/46796e8e82824b50b7abd1c1cb368e3b
Autor:
Rita Turnaturi, Silvia Piana, Salvatore Spoto, Giuliana Costanzo, Lorena Reina, Lorella Pasquinucci, Carmela Parenti
Publikováno v:
Molecules, Vol 28, Iss 20, p 7089 (2023)
Pain continues to be an enormous global health challenge, with millions of new untreated or inadequately treated patients reported annually. With respect to current clinical applications, opioids remain the mainstay for the treatment of pain, althoug
Externí odkaz:
https://doaj.org/article/5852bcb8f00a4830b894225ec3b619a3
Autor:
Giuliana Costanzo, Rita Turnaturi, Carmela Parenti, Salvatore Spoto, Silvia Piana, Maria Dichiara, Chiara Zagni, Anna Rita Galambos, Nariman Essmat, Agostino Marrazzo, Emanuele Amata, Mahmoud Al-Khrasani, Lorella Pasquinucci
Publikováno v:
Molecules, Vol 28, Iss 12, p 4827 (2023)
In this work, we report on the in vitro and in vivo pharmacological properties of LP1 analogs to complete the series of structural modifications aimed to generate compounds with improved analgesia. To do that, the phenyl ring in the N-substituent of
Externí odkaz:
https://doaj.org/article/e704a326999c4ff3b128293aa8a6660a
Autor:
Annamaria Fidilio, Margherita Grasso, Rita Turnaturi, Giuseppe Caruso, Federica Maria Spitale, Nunzio Vicario, Rosalba Parenti, Salvatore Spoto, Nicolò Musso, Agostino Marrazzo, Santina Chiechio, Filippo Caraci, Lorella Pasquinucci, Carmela Parenti
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Neuropathic pain is one of the most disabling forms of chronic pain and it is characterized by hyperalgesia and allodynia linked to an aberrant processing of pain transmission and to neuroinflammation. Transforming growth factor-β1 (TGF-β1) is an a
Externí odkaz:
https://doaj.org/article/2a619d81aa474855b2154eabc90b5207
Autor:
Rita Turnaturi, Santina Chiechio, Lorella Pasquinucci, Salvatore Spoto, Giuliana Costanzo, Maria Dichiara, Silvia Piana, Margherita Grasso, Emanuele Amata, Agostino Marrazzo, Carmela Parenti
Publikováno v:
Molecules, Vol 27, Iss 16, p 5135 (2022)
Although opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common drugs used in persistent pain treatment; they have shown many side effects. The development of new analgesics endowed with mu opioid receptor/delta opioid receptor
Externí odkaz:
https://doaj.org/article/fa89ceaf72aa4b489cc7b67a2f3fc901
Autor:
Angelo Spadaro, Lorella Pasquinucci, Miriam Lorenti, Ludovica Maria Santagati, Maria Grazia Sarpietro, Rita Turnaturi, Carmela Parenti, Lucia Montenegro
Publikováno v:
Applied Sciences, Vol 11, Iss 21, p 10250 (2021)
A synthetic dual-target mu opioid peptide receptor/delta opioid peptide receptor anti-nociceptive ligand, named LP2, has emerged as a promising candidate for the management of acute and/or persistent pain, but its lipophilicity limits further develop
Externí odkaz:
https://doaj.org/article/102302aa0a4c48a2987cd36f2ca7f7f8
Autor:
Pasquinucci, Giuliana Costanzo, Rita Turnaturi, Carmela Parenti, Salvatore Spoto, Silvia Piana, Maria Dichiara, Chiara Zagni, Anna Rita Galambos, Nariman Essmat, Agostino Marrazzo, Emanuele Amata, Mahmoud Al-Khrasani, Lorella
Publikováno v:
Molecules; Volume 28; Issue 12; Pages: 4827
In this work, we report on the in vitro and in vivo pharmacological properties of LP1 analogs to complete the series of structural modifications aimed to generate compounds with improved analgesia. To do that, the phenyl ring in the N-substituent of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::b482d84214d799ae346fe4ba0c812efc
Autor:
Lorella Pasquinucci, Carmela Parenti, Zafiroula Georgoussi, Lorena Reina, Emilia Tomarchio, Rita Turnaturi
Publikováno v:
Molecules, Vol 26, Iss 14, p 4168 (2021)
Although persistent pain is estimated to affect about 20% of the adult population, current treatments have poor results. Polypharmacology, which is the administration of more than one drug targeting on two or more different sites of action, represent
Externí odkaz:
https://doaj.org/article/a351c3754d5d4c5dbf87fc1611684c66
Autor:
Antonio Rescifina, Giuseppe Floresta, Agostino Marrazzo, Carmela Parenti, Orazio Prezzavento, Giovanni Nastasi, Maria Dichiara, Emanuele Amata
Publikováno v:
Data in Brief, Vol 13, Iss , Pp 514-535 (2017)
The data have been obtained from the Sigma-2 Receptor Selective Ligands Database (S2RSLDB) and refined according to the QSAR requirements. These data provide information about a set of 548 Sigma-2 (σ2) receptor ligands selective over Sigma-1 (σ1) r
Externí odkaz:
https://doaj.org/article/59aa3cfb9e8e4e33a7b014ee4e3f2a59
Autor:
Filippo Caraci, Sara Merlo, Filippo Drago, Giuseppe Caruso, Carmela Parenti, Maria Angela Sortino
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Different types of pain can evolve toward a chronic condition characterized by hyperalgesia and allodynia, with an abnormal response to normal or even innocuous stimuli, respectively. A key role in endogenous analgesia is recognized to descending nor
Externí odkaz:
https://doaj.org/article/6f9f5e252c234c169bda7558c65470f3