Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Carmela Pantaleon"'
Autor:
Lynn R. Webster, Carmela Pantaleon, Matthew Iverson, Michael D. Smith, Eric R. Kinzler, Stefan Aigner
Publikováno v:
Pain Research and Management, Vol 2018 (2018)
Objective. To investigate the pharmacokinetics (PK) of Morphine ARER, an extended-release (ER), abuse-deterrent formulation of morphine sulfate after oral and intranasal administration. Methods. This randomized, double-blind, double-dummy, placebo-co
Externí odkaz:
https://doaj.org/article/91ee9652c6364d84bc04ae6f56c463fb
Publikováno v:
Journal of Opioid Management. 16:383-390
Objective: Immediate-release (IR) oxycodone formulations may be manipulated for nonoral routes of administration. Oxycodone abuse-resistant immediate-release (ARIR) is a novel abuse-deterrent formulation (ADF) of IR oxycodone. This study aimed to ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afe939cc577e0891488c481319e3e3f
https://doi.org/10.5055/jom.2020.0593
https://doi.org/10.5055/jom.2020.0593
Publikováno v:
Advances in Therapy
Introduction Food can alter the pharmacokinetics of certain abuse-deterrent formulations. Morphine ARER is an oral abuse-deterrent formulation of ER morphine sulfate tablets formulated with physical and chemical properties that contribute to the abus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2930bbd65086d4e6ea5b03bcb443af
http://europepmc.org/articles/PMC6822839
http://europepmc.org/articles/PMC6822839
Publikováno v:
Advances in Therapy
Introduction Oxycodone ARIR is a novel oral, abuse-deterrent, immediate-release (IR) formulation with physical and chemical properties that deter misuse and abuse by non-oral routes. In this single-dose pharmacokinetic study, we assessed the relative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d8c3b0abdae291a2ba38cf51fe1f26
https://doi.org/10.1007/s12325-019-00963-0
https://doi.org/10.1007/s12325-019-00963-0
Publikováno v:
The American Journal of Drug and Alcohol Abuse. 45:377-384
Background: Extended-release (ER) morphine formulations are commonly manipulated for non-oral routes of administration, particularly via injection. Morphine ARER, an abuse-deterrent formulation of ER morphine, has both physical and chemical propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c4372cb44a50b061d375b2c0ab17a8
https://doi.org/10.1080/00952990.2019.1599383
https://doi.org/10.1080/00952990.2019.1599383
Publikováno v:
Clinical Therapeutics. 40:1357-1365
Purpose Morphine ARER is a novel oral, abuse-deterrent, extended-release (ER) formulation of morphine sulfate with physical and chemical properties that deter misuse and abuse by nonoral routes of administration. Here we evaluate the relative bioavai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93986c51e0350645510d809ad8539c15
https://doi.org/10.1016/j.clinthera.2018.06.010
https://doi.org/10.1016/j.clinthera.2018.06.010
Autor:
Matthew Iverson, Lynn R. Webster, Michael D. Smith, Stefan Aigner, Carmela Pantaleon, Eric R. Kinzler
Publikováno v:
Pain Medicine: The Official Journal of the American Academy of Pain Medicine
Objective Prescription opioid abuse continues to be a public health concern. Oxycodone ARIR is an immediate-release (IR) oxycodone tablet composed of multiple overlapping barriers that deter manipulation of the tablet for non-oral abuse. Design This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7d526cca6efd9b47f58930716827d9
https://doi.org/10.1093/pm/pny043
https://doi.org/10.1093/pm/pny043
Autor:
Michael D. Smith, Carmela Pantaleon, Lynn R Webster, Stefan Aigner, Matthew Iverson, Eric R. Kinzler
Publikováno v:
Pain Research & Management
Pain Research and Management, Vol 2018 (2018)
Pain Research and Management, Vol 2018 (2018)
Objective. To investigate the pharmacokinetics (PK) of Morphine ARER, an extended-release (ER), abuse-deterrent formulation of morphine sulfate after oral and intranasal administration. Methods. This randomized, double-blind, double-dummy, placebo-co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47660a619aeb7318e230b352bfcd26b1
Autor:
Carmela Pantaleon, Ray J. Difalco, Lynn R. Webster, Michael D. Smith, Matthew Iverson, Stefan Aigner, Manish S. Shah, Eric R. Kinzler
Publikováno v:
Pain medicine (Malden, Mass.). 18(7)
Objective. Misuse and abuse of prescription opioids remains a major healthcare concern despite considerable efforts to increase public awareness. Abuse-deterrent formulations of prescription opioids are designed to reduce intentional misuse, abuse, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d999ae2ef04857fc9590ffb135f7408a
https://pubmed.ncbi.nlm.nih.gov/27651506
https://pubmed.ncbi.nlm.nih.gov/27651506
Publikováno v:
Clinical Therapeutics. 27:472-483
Gastroesophageal reflux disease (GERD), which is reflux that produces damage or troubling symptoms, afflicts approximately 7% of infants and children to the extent that administration of physician-directed pharmacotherapy is warranted.This study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f5b4c296f7f2709f08d3ac14bc879f
https://doi.org/10.1016/j.clinthera.2005.04.008
https://doi.org/10.1016/j.clinthera.2005.04.008