Long-term effects of early antiretroviral initiation on HIV reservoir markers: a longitudinal analysis of the MERLIN clinical study

Autor: Marta Massanella, PhD, Rachel A Bender Ignacio, MD, Javier R Lama, MD, Amélie Pagliuzza, MSc, Sayan Dasgupta, PhD, Ricardo Alfaro, MS, Jessica Rios, MS, Carmela Ganoza, MD, Delia Pinto-Santini, PhD, Trupti Gilada, MD, Ann Duerr, ProfMD, Nicolas Chomont, PhD

Publikováno v: The Lancet Microbe, Vol 2, Iss 5, Pp e198-e209 (2021)

Summary: Background: Early antiretroviral therapy (ART) initiation (ie, within 3 months of infection) limits establishment of the HIV reservoir. However, the effect of early ART initiation on the long-term dynamics of the pool of infected cells remai

Externí odkaz: https://doaj.org/article/edfb4035302a4262bf5cbdd8a1fc440f

Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control.

Autor: Bruna Oriol-Tordera, Maria Berdasco, Anuska Llano, Beatriz Mothe, Cristina Gálvez, Javier Martinez-Picado, Jorge Carrillo, Julià Blanco, Clara Duran-Castells, Carmela Ganoza, Jorge Sanchez, Bonaventura Clotet, Maria Luz Calle, Alex Sánchez-Pla, Manel Esteller, Christian Brander, Marta Ruiz-Riol

Publikováno v: PLoS Pathogens, Vol 16, Iss 8, p e1008678 (2020)

GWAS, immune analyses and biomarker screenings have identified host factors associated with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms that regulate the expression of such host factors. Here, we aimed to asse

Externí odkaz: https://doaj.org/article/932994bc041b404db54d93aecb303cb6

Transient Peripheral Immune Activation follows Elective Sigmoidoscopy or Circumcision in a Cohort Study of MSM at Risk of HIV Infection.

Autor: Javier R Lama, Shelly T Karuna, Shannon P Grant, Edith M Swann, Carmela Ganoza, Patricia Segura, Silvia M Montano, Martin Lacherre, Stephen C De Rosa, Susan Buchbinder, Jorge Sanchez, M Juliana McElrath, Maria P Lemos, HVTN 914 Study Team

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0160487 (2016)

Rectal and genital sampling in HIV prevention trials permits assessments at the site of HIV entry. Yet the safety and acceptability of circumcision and sigmoidoscopy (and associated abstinence recommendations) are unknown in uncircumcised men who hav

Externí odkaz: https://doaj.org/article/f29ea4550ac24b8ca88705169b8bb97e

Antiretroviral Initiation at ≥800 CD4+ Cells/mm3 Associated With Lower Human Immunodeficiency Virus Reservoir Size

Autor: Thomas A Rasmussen, Sunil K Ahuja, Locadiah Kuwanda, Michael J Vjecha, Fleur Hudson, Luxshimi Lal, Ajantha Rhodes, Judy Chang, Sarah Palmer, Paula Auberson-Munderi, Henry Mugerwa, Robin Wood, Sharlaa Badal-Faesen, Sandy Pillay, Rosie Mngqibisa, Alberto LaRosa, Jose Hildago, Kathy Petoumenos, Chris Chiu, Joseph Lutaakome, Jonathan Kitonsa, Esther Kabaswaga, Pietro Pala, Carmela Ganoza, Katie Fisher, Christina Chang, Sharon R Lewin, Edwina J Wright

Publikováno v: Rasmussen, T A, Ahuja, S K, Kuwanda, L, Vjecha, M J, Hudson, F, Lal, L, Rhodes, A, Chang, J, Palmer, S, Auberson-Munderi, P, Mugerwa, H, Wood, R, Badal-Faesen, S, Pillay, S, Mngqibisa, R, LaRosa, A, Hildago, J, Petoumenos, K, Chiu, C, Lutaakome, J, Kitonsa, J, Kabaswaga, E, Pala, P, Ganoza, C, Fisher, K, Chang, C, Lewin, S R & Wright, E J 2022, ' Antiretroviral Initiation at ≥800 CD4+ Cells/mm3 Associated With Lower Human Immunodeficiency Virus Reservoir Size ', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 75, no. 10, pp. 1781-1791 . https://doi.org/10.1093/cid/ciac249

Background Identifying factors that determine the frequency of latently infected CD4+ T cells on antiretroviral therapy (ART) may inform strategies for human immunodeficiency virus (HIV) cure. We investigated the role of CD4+ count at ART initiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f116ba0824e2958cc89046c4f89b6ea9
https://doi.org/10.1093/cid/ciac249

Sexual Behavior and Sexually Transmitted Infection Outcomes Among Men Who Have Sex With Men and Transgender Women Participating in a Study of the Timing of Antiretroviral Therapy in Lima, Peru

Autor: Pedro Gonzales, Javier R. Lama, Ann Duerr, Jorge Sanchez, Tara E. Ness, Michalina A Montaño, Carmela Ganoza, Ricardo Alfaro

Publikováno v: Sexually Transmitted Diseases. 47:825-831

BACKGROUND We assessed sexual behavior and incidence of sexually transmitted infections (STIs) among men who have sex with men and transgender women participating in Sabes, a study of an expanded treatment as prevention strategy focused on early diag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f2a6e4b36421f2255e1ce6eb5b5c781
https://doi.org/10.1097/olq.0000000000001310