Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia

Autor: Carmela Gómez, Rósula Garcia-Navas, Fernando C. Baltanás, Rocío Fuentes-Mateos, Alberto Fernández-Medarde, Nuria Calzada, Eugenio Santos

Publikováno v: Cancers; Volume 14; Issue 16; Pages: 3893

We showed previously that the ABL-mediated phosphorylation of SOS1 promotes RAC activation and contributes to BCR-ABL leukemogenesis, suggesting the relevant role of SOS1 in the pathogenesis of CML. To try and obtain direct experimental evidence of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af1f3901a90c311024b32878236a3cf
https://hdl.handle.net/10668/20912

Ras-GRF2 regulates nestin-positive stem cell density and onset of differentiation during adult neurogenesis in the mouse dentate gyrus

Autor: Eugenio Santos, Alberto Fernández-Medarde, Carmela Gómez, Rósula García-Navas, David Jimeno, Nuria Calzada

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Various parameters of neurogenesis were analyzed in parallel in the two neurogenic areas (the Dentate Gyrus[DG] and the Subventricular Zone[SVZ]/Rostral Migratory Stream[RMS]/Main Olfactory Bulb[MOB] neurogenic system) of adult WT and KO mouse strain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b9ac0af412b7adb3ae50c334c579e3
https://doi.org/10.1016/j.mcn.2017.09.006

Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis

Autor: Jesús M. Paramio, Mauricio Menacho-Márquez, Nuria Calzada, Xosé R. Bustelo, Carmela Gómez, P. Liceras-Boillos, Rocío Fuentes-Mateos, Rósula García-Navas, Eugenio Santos, Fernando C. Baltanás, Carmen Segrelles, L. Francisco Lorenzo-Martín, David Jimeno

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
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Using Sos1 knockout (Sos1-KO), Sos2-KO, and Sos1/2 double-knockout (Sos1/2-DKO) mice, we assessed the functional role of Sos1 and Sos2 in skin homeostasis under physiological and/or pathological conditions. Sos1 depletion resulted in significant alte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2553a5e4ca0663b4a6badf276889ab32
https://pubmed.ncbi.nlm.nih.gov/29844066

Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis

Autor: Martina Zobel, Y Rolland, Juri Rappsilber, Anna Lena Illert, Chiara Giuliani, M Cinquanta, Eugenio Santos, S Kreutmair, Giancarlo Pruneri, Emanuela Frittoli, Giorgio Scita, Saverio Minucci, Carmela Gómez, Mogjiborahman Salek, Isabella Pallavicini, Flavia Troglio, Silke Gerboth, Andrea Palamidessi, Fernando C. Baltanás

Publikováno v: Gerboth, S, Frittoli, E, Palamidessi, A, Baltanas, F C, Salek, M, Rappsilber, J, Giuliani, C, Troglio, F, Rolland, Y, Pruneri, G, Kreutmair, S, Pallavicini, I, Zobel, M, Cinquanta, M, Minucci, S, Gomez, C, Santos, E, Illert, A L & Scita, G 2017, ' Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis ', Leukemia, vol. 32, no. 3, pp. 820-827 . https://doi.org/10.1038/leu.2017.267
Digital.CSIC. Repositorio Institucional del CSIC
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Leukemia

Son of Sevenless 1 (SOS1) is a dual guanine nucleotide exchange factor (GEF) that activates the small GTPases RAC and RAS. Although the molecular mechanisms of RAS GEF catalysis have been unveiled, how SOS1 acquires RAC GEF activity and what is the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb12c63e4dffbd9e5bca4d69d3fc5d5
https://hdl.handle.net/20.500.11820/bc8340f1-0ae4-4c45-b4ed-5e0ef373b63b

The Olfactory System as a Puzzle: Playing With Its Pieces

Autor: Fernando C. Baltanás, David Díaz, Eduardo Weruaga, José R. Alonso, Carmela Gómez, Rodrigo Muñoz-Castañeda

Publikováno v: The Anatomical Record. 296:1383-1400

The mammalian olfactory bulb (OB) has all the features of a whole mammalian brain but in a more reduced space: neuronal lamination, sensory inputs, afferences, or efferences to other centers of the central nervous system, or a contribution of new neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26dce9feb8603092556f92f6f60ca14e
https://doi.org/10.1002/ar.22748